[OA] Public Needs To Prep For Vaccine Side Effects
This summer, computational biologist Luke Hutchison volunteered for a trial of Moderna's COVID-19 vaccine. But after the second injection, his arm swelled up to the size of a “goose egg,” Hutchison says. He can't be sure he got the vaccine and not a placebo, but within a few hours, Hutchison, who was healthy and 43, was beset by bone and muscle aches and a 38.9°C fever. “I started shaking. I had cold and hot rushes,” he says. “I was sitting by the phone all night long thinking: ‘Should I call 911?’”
Hutchison's symptoms resolved after 12 hours. But, he says, “Nobody prepared me for the severity of this.”
He says the public should be better prepared than he was, because a subset of people may face intense, if transient, side effects, called reactogenicity, from Moderna's vaccine. Some health experts agree.
“Somebody needs to address the elephant: What about vaccine reactogenicity? While it's … not going to cause any long-term issues … how is that perception going to go with the public once they start receiving it?” asks Deborah Fuller, a vaccinologist at the University of Washington, Seattle, whose lab is developing second-generation RNA vaccines against COVID-19. She worries the side effects could feed vaccine hesitancy. “I feel like it's being glossed over.”
Those concerns arise after a week of good news about coronavirus vaccines: Both Moderna and Pfizer, with BioNTech, announced their messenger RNA (mRNA) vaccines reached 95% efficacy in clinical trials of tens of thousands of people. The firms added that the trials showed no serious safety concerns.
Both vaccines consist of a snippet of genetic code directing production of the coronavirus' spike protein, delivered in a tiny fat bubble called a lipid nanoparticle. Some researchers suspect the immune system's response to that delivery vehicle is causing the short-term side effects.
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Wadman M. Public needs to prep for vaccine side effects. Science 2020;370:1022. http://science.sciencemag.org/content/370/6520/1022.abstract