I'm currently on gh(10 IUS) using metformin 1500, reta, berberine, Lantus 20ius morning/night, humalog 7 with breakfeast, pre workout meal and post workout meal to help keep insulin sensativity. Does anyone have any recommendations for any other compounds/changes that may help? Cardio is everyday post workout, carbs are around ~400.
MESO-Rx
Anabolic Steroids
compounds that help blood sugar
- Thread starter thedon966
- Start date
Trenbolonetax
Well-known Member
This doesn’t make sense lol. Literally throwing in the kitchen sink and having trouble controlling BG on 400 carbs?
I mean fuck might as well just throw in SLUPP, Cardarine, and Mots-C at this point, too.
When do you take your GH? What dose of Reta?
I mean fuck might as well just throw in SLUPP, Cardarine, and Mots-C at this point, too.
When do you take your GH? What dose of Reta?
It's not too bad for glucose control from the studies, it's just a bit below the other two
Btw sema is better for glucose control then tirz if I don't remember wrong.
Trenbolonetax
Well-known Member
- Semaglutide: Studies (e.g., SUSTAIN trials) show significant HbA1c reduction (~1.8% at maximum doses) and weight loss.
- Tirzepatide: Outperforms semaglutide in trials (SURPASS studies) with greater HbA1c reduction (~2.0% or more) and more substantial weight loss.
My bad I remembered wrong.
What's the reta value instead?
Trenbolonetax
Well-known Member
In a 36-week Phase 2 study, participants receiving retatrutide experienced dose-dependent HbA1c reductions:
- 4 mg dose: Reduction of approximately 1.3%
- 8 mg dose: Reduction of approximately 1.6%
- 12 mg dose: Reduction of up to 2.02%
Not horrible I would say, especially because the TIRZ 2.0% if I'm not mistaken is 10mg or more. I couldn't even eat at 2.5mg lol
Retatrutide shows a dose-dependent trend in HbA1c reduction:
At 4 mg, reductions are modest, with values around -0.43%.
The 8 mg dose results in a greater reduction of approximately -1.5%.
At the 12 mg dosage, HbA1c reduction peaks at about -2.02%.
That's what my AI says xD
Let me check Tirzepatide
Trenbolonetax
Well-known Member
Damn… I don’t even think I felt the 2.5mg of tirz lol. I mean even with 15mg Reta on board I crushed 3 sausage egg McMuffin, 1 bacon egg cheese sandwich from McDonalds…also 1 hash brown breakfast burrito + 1 churro from taco shop in the last 2.5 hours.
Disclaimer: this is a bad idea
Ghoul
Well-known Member
Results all depend on study design, but 2%+plus HBA1C reduction at 5mg Tirz isn't uncommon and 3%+ at 15mg.
The result at 5mg is significant if someone isn't looking for weight reduction, because with Reta you need to be at the higher doses to hit 2%.
All this because the artificial 39 amino acid limit forces compromises. Another 10-20 aminos on the chain would allow the king of all these compounds to be made.
Tirzepatide demonstrates a dose-dependent reduction in HbA1c levels:
At 5 mg, the reduction ranges from -2.01% to -2.24%.
At 10 mg, reductions increase to -2.44% to -2.49%.
The 15 mg dose shows the most significant effect, with reductions of approximately -2.37% to -2.58%.
Yeah TIRZ seems better but reta it says it's better than semaglutide at least from 8mg or more
At 2.5 it was bad at 5mg I had acid burps all the time and my appetite was dead.
Probably with times it would have fixed itself but I didn't have the time as I wanted to bulk, so I dropped it.
Trenbolonetax
Well-known Member
Since those studies don’t strip out weight reduction from the impact it has on A1C, I wonder how much the additional weight loss from Reta is improving HBA1C compared to Sema.
Said differently, I’d like to see studies where weight is held constant and we can see varying impact of these 3 drugs on HBA1C.
Same with tirz maybe, it usually quicker in weight loss Vs retatrutide so what if the a1c reduction is in good part from that?
Who knows.
Imho if I hop on a glp-1 again it will be reta. It seems superior for us bodybuilder from reports of ppl around.
No fatigue like tirz, easier to eat on it etc.
Trenbolonetax
Well-known Member
I’m a glutton for punishment so I just suffered for awhile lol.
Don’t get me started on when I was max dose tirz + injecting full vial of AOD9604 daily from QSC, the ones that were contaminated with .2mg of Sema…man that was a miserable week. I wondered why I was puking and having insane diarrhea…
29trt
Well-known Member
What is this all glp talk have to do with anything ?
Are there any studies on bodybuilders on a bulk with 10ui GH+ insulin + AAS ?
I am willing to bet any glp is going to do jack shit if I manage to still eat in a surplus ( which I did on 1mg Sema all it got me is bloated, BG still was high without other GDA on 2g of gear and 18UI hgh) regarding BG and HBA1C ....
I haven't read any of the studies so I defer to you Ghoul I see HBA1C mentioned every time but you know as well as I do that is not a measure of insulin resistance, where they measuring HOMA IR or an equivalent?
Are there any studies on bodybuilders on a bulk with 10ui GH+ insulin + AAS ?
I am willing to bet any glp is going to do jack shit if I manage to still eat in a surplus ( which I did on 1mg Sema all it got me is bloated, BG still was high without other GDA on 2g of gear and 18UI hgh) regarding BG and HBA1C ....
I haven't read any of the studies so I defer to you Ghoul I see HBA1C mentioned every time but you know as well as I do that is not a measure of insulin resistance, where they measuring HOMA IR or an equivalent?
Ghoul
Well-known Member
I haven't found head to head studies, but Tirz providing roughly 50% better improvement in insulin sensitivity at equivalent doses looks like a common result.
Honestly I'm not sold on Reta as anything but having a potentially higher max weight loss. While the "no fatigue like tirz" component seems at odds with what the trials show.
I think fatigue is common with both Sema and Tirz during the first 6-8 weeks, sometimes longer, but eventually resolves for most and by the time someone tries Reta they're mostly beyond that point.
I had massive fatigue on Sema, which eventually stopped, and never experienced it by the time I switched to Tirz.
I could be wrong. The glucagon effects in Reta haven't been nearly as deeply studied as GLP/GIP so maybe there's something there.
Last edited:
29trt
Well-known Member
Ok so they work for actual insulin sensitivity....BUT they are compared to baseline which is basically overweight sedentary people ,what about people at 5-10% body fat on a strict diet in a deficit ( as we all know people get really insulin sensitive in those circumstances anyway). Or the same bodybuilders with low body fat in a surplus ?
Will a GLP still provide significant benefits for HOMA IR if I manage to eat in a 500kcal surplus?
I am a bit skeptical of the current rhetoric of the people that sell these GLPs.... Don't get me wrong I wish there was an advantage of using reta while bulking but I think it's too early to tell ( and I am talking a significant difference in Homa ir not 0.5%)
Trenbolonetax
Well-known Member
I’ve been on 13iu of GH + 2+g AAS + 15mg of Reta the last couple of months. Bulked from 260ish to 300 (a lot is not real weight obviously but water retention due to several factors), and I’ve been eating like an absolute asshole.
I’m due to get bloods next week. Just have to schedule the appointment and go give it.
I’ll tag you if I remember when I post my bloods.
Also, there are some great rodent studies that demonstrate reduction in insulin required, both in the fed and fasted state, independent of weightloss.
