compounds that help blood sugar

[thedon966]

I'm currently on gh(10 IUS) using metformin 1500, reta, berberine, Lantus 20ius morning/night, humalog 7 with breakfeast, pre workout meal and post workout meal to help keep insulin sensativity. Does anyone have any recommendations for any other compounds/changes that may help? Cardio is everyday post workout, carbs are around ~400.

 

[Trenbolonetax]

Please tag me also.
Will you get both glucose and insulin?

Yes I'm getting both of those. I will tag you.

 

[29trt]

I'm a bit confused with this HOMA-IR thing. I had both insulin and BG in range and calculated HOMA was showing severe insulin resistance. How's it possible?

That was in the end of my bulk, i was already 25lbs up and after seeing that i decided to pull the plug, despite my excellent HbA1c.

So, fasted BG was 96 and fasted insulin 14,9. My HbA1c was 4,9. I was on 1gr cycle + oral, HGH 3,6 IU pre bed and 500mg berberine twice a day. Overall calories 4,500 - 4,800 with 720 carbs.

One thing i didn't know when i did this bloodwork is that taking HGH 12-24 hours before giving blood it affects both fasted insulin and BG, i don't know how much though but even the slightest decrease in both will result to a different HOMA IR outcome.

Unfortunately i haven't any fasted insulin when i started pushing food so i can't estimate HOMA to compare before and after.

This means your body is good at regulating BG .... In other words your pancreas is able to secrete enough insulin to keep your BG in range and with time that causes more and more insulin resistance as more an d more insulin is required to maintain homeostasis.

Gh affects homa ir because it makes you insulin resistant moreso than without it at the same level of carb intake so your homa IR is accurate and so is your hba1c....but if you stayed on that cycle and bulk for longer in time your hba1c would begin to rise as your pancreas was unable to secrete enough insulin to keep up

 

[Eddie.]

This means your body is good at regulating BG .... In other words your pancreas is able to secrete enough insulin to keep your BG in range and with time that causes more and more insulin resistance as more an d more insulin is required to maintain homeostasis.

Gh affects homa ir because it makes you insulin resistant moreso than without it at the same level of carb intake so your homa IR is accurate and so is your hba1c....but if you stayed on that cycle and bulk for longer in time your hba1c would begin to rise as your pancreas was unable to secrete enough insulin to keep up

Yeah, i understand that, A1c shows the amount of sugar in hemoglobin for the past 60-90 days and it's not the most accurate measurement if you want to see NOW how much insulin resistant you are.

What i don't get is the way it calculates the HOMA IR because i insert 2 in range measurements and (BG and insulin) and the test shows i'm insulin resistant. My score cames out 3,5 and >2 shows insulin resistance.

With simple words, shouldn't HOMA IR (calculated method) show a score greater than 2 when at least 1 of the 2 markers (BG or insulin) is way out of range? If not both..

Especially fasted BG, one day you wake up with 100 and next day maybe 82. That thing alone could lead to a vastly different outcome of the calculated HOMA IR, that's why i'm having a hard time trusting this method.

 

[MA11]

What i don't get is the way it calculates the HOMA IR because i insert 2 in range measurements and (BG and insulin) and the test shows i'm insulin resistant. My score cames out 3,5 and >2 shows insulin resistance.

You're insulin resistant because you need a hell of a lot insulin to reach that certain BG.

With simple words, shouldn't HOMA IR (calculated method) show a score greater than 2 when at least 1 of the 2 markers (BG or insulin) is way out of range? If not both..

These values are connected.

Your body needed 14.9 mIU/l insulin to reach a (border line okay) BG of 96 mg/do

An insulin sensitiv individual would have had a BG of 55 (!) with that amount of insulin (see random HOMA index calculators online).

Especially fasted BG, one day you wake up with 100 and next day maybe 82. That thing alone could lead to a vastly different outcome of the calculated HOMA IR, that's why i'm having a hard time trusting this method

Sure your BG varies from day to day, so does your insulin.

Example for HOMA index = 3:

BG 82 and insulin 14.9
BG 100 and insulin 12.

 

[MA11]

This means your body is good at regulating BG .... In other words your pancreas is able to secrete enough insulin to keep your BG in range and with time that causes more and more insulin resistance as more an d more insulin is required to maintain homeostasis.

Gh affects homa ir because it makes you insulin resistant moreso than without it at the same level of carb intake so your homa IR is accurate and so is your hba1c....but if you stayed on that cycle and bulk for longer in time your hba1c would begin to rise as your pancreas was unable to secrete enough insulin to keep up

Do you (or someone else) know at what point we fry out pancreas or damage our beta cells?
Is there some available knowledge to that or does anybody even care?
And I do NOT mean when A1c goes into prediabetic levels. I mean how long can I ride (safely) on pancreas (insulin) overdrive?

I would have never ever even considered that if my body wouldn't react with skin tags which probably were a sign of insulin resistance. I was bulking with 2.5+ IU HGH for a couple months. BG and A1c all fine. HOMA index at 2.4 after 3 weeks off HGH, so probably higher while on.

Insulin sensitivity causes lots of crap. More fat during bulk, worse lipids, inflammation, hypertension, etc.

Being young and low body fat is the best precaution.

 

[Trenbolonetax]

Do you (or someone else) know at what point we fry out pancreas or damage our beta cells?
Is there some available knowledge to that or does anybody even care?
And I do NOT mean when A1c goes into prediabetic levels. I mean how long can I ride (safely) on pancreas (insulin) overdrive?

I would have never ever even considered that if my body wouldn't react with skin tags which probably were a sign of insulin resistance. I was bulking with 2.5+ IU HGH for a couple months. BG and A1c all fine. HOMA index at 2.4 after 3 weeks off HGH, so probably higher while on.

Insulin sensitivity causes lots of crap. More fat during bulk, worse lipids, inflammation, hypertension, etc.

Being young and low body fat is the best precaution.

I don’t have an answer to your questions. However, I think a good practice in general is to take a couple months out of the year and do a very methodical “insulin sensitivity reset”; very low carb or keto ideally + deficit + GLP1 + mitochondrial optimization peptides + exercise mimetics / PPAR agonist + whatever else I’m missing.

I realize this isnt incredibly different than just going into a cut cycle, but I mean doing this for the purpose of optimizing metabolic health and not just to cut body fat.

Another thought is that in progressive phases, the carb cycling approach makes a ton of sense to extend the length of time you can stay in the massing phase before needing to pull back and do a “reset” due to attenuating the slow insulin resistance build up. Also gives more motivation to find optimal GH timing so you’re not pushing big carbs in the most acutely insulin resistant portion of the day (e.g, around GH timing).

Having said all of this, I’m insanely curious what my fasting insulin + A1C + homa IR will be after 2.5 months of fuck it eating while putting on 40 pounds since August

 

[MA11]

It does make sense, the metabolism needs some time off.
I also realize (more than before) how important it is to be lean while bulking. Insulin resistance is strongly influenced by body fat.

Having said all of this, I’m insanely curious what my fasting insulin + A1C + homa IR will be after 2.5 months of fuck it eating while putting on 40 pounds since August

Me too!
What's your guess when it comes to your body fat percentage if I may ask?

 

[Trenbolonetax]

It does make sense, the metabolism needs some time off.
I also realize (more than before) how important it is to be lean while bulking. Insulin resistance is strongly influenced by body fat.

Definitely. And nutrient partitioning is strongly influenced by insulin sensitivity lol it’s a circle

Me too!
What's your guess when it comes to your body fat percentage if I may ask?

I’ve got no idea man. I’ve never been good at that. A million pictures in my log from the last couple months. Maybe I’m 16%? Not really sure

 

[MA11]

Oh I see. Damn, you did a great job.