Curcumin and fat loss.

MisterSuperGod

Well-known Member
i found this posted on another forum and found it interesting. The mouse testing doesn't fill me with confidence, but i'm still curious what your take on it is and if anyone has any experiences to share.


A Newly Discovered Turmeric Curcumin Benefit

CURCUMIN: HEALTH BOOSTER, FAT BUSTER


The list of curcumin's benefits keeps growing. Curcumin started off as an effective pain reliever and anti-inflammatory, but then we found out it also blocks estrogen, boosts testosterone, improves heart health, makes you stronger, dissolves arterial plaques, stops your knees from aching, and reduces the risk of diabetes.

And now there's new research showing that curcumin causes fat cells to undergo apoptosis, which is the term for cellular suicide. When apoptosis begins, the surface of the cell starts to bubble and churn, almost like it's boiling. Then, its nucleus starts to fragment. Eventually, the cell tears asunder, spilling its disassociated guts into the interstitial sea of fluid.

A cellular clean-up crew of phagocytes, one accustomed to wet work, arrives to dispose of the corpses and there's no investigation because they know curcumin was to blame.

This new curcumin research also shows that curcumin prevents pre-adipocytes – baby fat cells – from developing into full-blown adipocytes. These baby fat cells are urged to go into a different profession... or else.

Here's a summary of the science and what it means for you.

The Taiwanese researchers who conducted this study already knew from a few recent studies that curcumin supplementation reduces a high-fat diet-induced increase in body fat, but they didn't know the mechanism behind curcumin's hate for plumpness.

To figure it out, they exposed mouse pre-adipocytes to varying concentrations of curcumin for varying time frames. They also exposed pre-adipocytes to a low dosage of curcumin for an hour, followed by a 24-hour incubation period.

They found that curcumin inhibited adipocyte differentiation. In other words, the supplement prevents fat cells from maturing and fulfilling their ultimate function, which is to store fat.

The high doses of curcumin actually caused fat cells to commit suicide, while the lower doses prevented the maturation of the baby fat cells. They suspect it had to do with curcumin's modulating effects on something known as the Wnt/beta-catenin signaling pathway, which helps determine the fate of cells.

The authors, despite seemingly being tight-lipped PhD guys, seemed pretty jazzed, writing:

"These findings suggest that curcumin supplementation could be an effective strategy for treating or preventing development of obesity by a curcumin-induced reduction in the number or pre-adopocytes and the fat mass of adipocytes."

When you think about it, curcumin's effects on fat cells may have something to do with many of the other benefits listed in the opening paragraph of this article.

Collectively, our fat cells are considered to be a major endocrine organ with a powerful impact on things like the regulation of appetite, insulin sensitivity, immunological responses, and vascular disease, so if curcumin causes fewer fat cells to form while causing others to expire, it makes sense that it would have so many beneficial side effects.

As far as how much curcumin to take to experience any reduction in fat mass, it's difficult to say.

The scientists exposed the fat cells to a concentration of up to 50 micrograms of curcumin to make them commit hari-kari, and 30 micrograms to keep pre-adipocytes from forming into full-fledged adipocytes, but given that the body weights of us human is so diverse, it's hard to extrapolate a suitable dosage.

But, given that 30 micrograms is awfully small (a thousand micrograms equals 1 milligram), I feel confident in suggesting that the standard Biotest dosage of curcumin would bring the average person into therapeutic range.

Source:
  1. Liang-Yi Wu et al. Curcumin Attenuates Adipogenesis by Inducing Preadipocyte Apoptosis and Inhibiting Adipocyte Differentiation. Nutrients
 
Curcumin is a scam product,i took it multiple times and it never did anything to inflammation or anything else.I mean just look at the studies lmao most of them come from india and china were curcumin is exported so i wouldn't pay to much attention to it.Just look at the first text,pain reliver,anti inflammatory,blocks estrogen,boosts testosterone,improves heart health,makes you stronger... Lol
 
i found this posted on another forum and found it interesting. The mouse testing doesn't fill me with confidence, but i'm still curious what your take on it is and if anyone has any experiences to share.


A Newly Discovered Turmeric Curcumin Benefit

CURCUMIN: HEALTH BOOSTER, FAT BUSTER


The list of curcumin's benefits keeps growing. Curcumin started off as an effective pain reliever and anti-inflammatory, but then we found out it also blocks estrogen, boosts testosterone, improves heart health, makes you stronger, dissolves arterial plaques, stops your knees from aching, and reduces the risk of diabetes.

And now there's new research showing that curcumin causes fat cells to undergo apoptosis, which is the term for cellular suicide. When apoptosis begins, the surface of the cell starts to bubble and churn, almost like it's boiling. Then, its nucleus starts to fragment. Eventually, the cell tears asunder, spilling its disassociated guts into the interstitial sea of fluid.

A cellular clean-up crew of phagocytes, one accustomed to wet work, arrives to dispose of the corpses and there's no investigation because they know curcumin was to blame.

This new curcumin research also shows that curcumin prevents pre-adipocytes – baby fat cells – from developing into full-blown adipocytes. These baby fat cells are urged to go into a different profession... or else.

Here's a summary of the science and what it means for you.

The Taiwanese researchers who conducted this study already knew from a few recent studies that curcumin supplementation reduces a high-fat diet-induced increase in body fat, but they didn't know the mechanism behind curcumin's hate for plumpness.

To figure it out, they exposed mouse pre-adipocytes to varying concentrations of curcumin for varying time frames. They also exposed pre-adipocytes to a low dosage of curcumin for an hour, followed by a 24-hour incubation period.

They found that curcumin inhibited adipocyte differentiation. In other words, the supplement prevents fat cells from maturing and fulfilling their ultimate function, which is to store fat.

The high doses of curcumin actually caused fat cells to commit suicide, while the lower doses prevented the maturation of the baby fat cells. They suspect it had to do with curcumin's modulating effects on something known as the Wnt/beta-catenin signaling pathway, which helps determine the fate of cells.

The authors, despite seemingly being tight-lipped PhD guys, seemed pretty jazzed, writing:

"These findings suggest that curcumin supplementation could be an effective strategy for treating or preventing development of obesity by a curcumin-induced reduction in the number or pre-adopocytes and the fat mass of adipocytes."

When you think about it, curcumin's effects on fat cells may have something to do with many of the other benefits listed in the opening paragraph of this article.

Collectively, our fat cells are considered to be a major endocrine organ with a powerful impact on things like the regulation of appetite, insulin sensitivity, immunological responses, and vascular disease, so if curcumin causes fewer fat cells to form while causing others to expire, it makes sense that it would have so many beneficial side effects.

As far as how much curcumin to take to experience any reduction in fat mass, it's difficult to say.

The scientists exposed the fat cells to a concentration of up to 50 micrograms of curcumin to make them commit hari-kari, and 30 micrograms to keep pre-adipocytes from forming into full-fledged adipocytes, but given that the body weights of us human is so diverse, it's hard to extrapolate a suitable dosage.

But, given that 30 micrograms is awfully small (a thousand micrograms equals 1 milligram), I feel confident in suggesting that the standard Biotest dosage of curcumin would bring the average person into therapeutic range.

Source:
  1. Liang-Yi Wu et al. Curcumin Attenuates Adipogenesis by Inducing Preadipocyte Apoptosis and Inhibiting Adipocyte Differentiation. Nutrients
So whomever wrote this article is highly entertaining, I will give them that. However they also are scientifically illiterate.

This was an in vitro study done in a petri dish.

Three MASSIVE ERRORS in the article thay you posted (made by the author, TC Luoma at T-Nation, these are unrelated to the study itself):
1. They say the researchers exposed tthe pre-adipocytes to "30 micrograms up to 50 micrograms." So the author doesn't know the difference between micrograms and microMOLES?? The unit used throughout the article is micromoles, or μM. These are very, very different things.
For those interested, the molecular weight of curcumin is 368.3799, thus the actual amount of curcumin used (based off the 30μM dose) was 1.10514x10^-8, or about 10 nanograms. This makes sense given that their "subject" is just miniscule number of pre-adipocyte cells.
2. Even if it was mcg, there is still a mouse to human dose conversion that would need to take place.
3. This study was done IN VITRO (which is also why the doses are so fucking miniscule). The author doesn't even mention or acknowledge this at all other than the fact that only some will pick up on where they saybthey expoaed mouse pre-adipocytes. To me thisnobviously means isolated cells, aka in vitro, but many would think they simply gave this shit to a mouse and the mouse lost fat.
Bonus: At the end they put a plug in for Biotest which, to me, means that the whole article is really just a front to get people to buy Biotest. Fuck Biotest.

The author may or may not be literate enough to understand the mistakes they made in their writing. I don't know. I personally think T-nation should take this shit article down because it is blatant misinformation.. Regardless, fuck Biotest.

@Albozz is 100% correct. It is unfortunate that the research on curcumin (and others such as ashwagandha, ginseng, etc.) have all been carried out by researchers in the countries thay export the product they're studying. This is what we call a conflict of interest.

There are several types of conflicts of interest:
1. Funding: someone funded the study that would benefit from the results going one way or another
2. Vested interests: the researchers themselves have stock or some financial interest and would benefit from the results going a certain way
3. Regional interest: this is the case above. The countries of India and china would benefit from increased curcumin sales. By publishing a study that encourages people to buy more of it, the authors are more likely to get funding because the state can see it will being them additional export revenue.

All of these can encourage researchers to set up an experiment so it is more likely to produce a desired result. This can be accomplished by setting up the methods a certain way such as using in vitro vs in vivo or selecting/excluding specific measurements from their methods/data to ensure they only demonstrate positive results, plus many more I won't take the time to list.

Always keep an eye out for these conflicts; from what I've seen, they are especially lxcommon in the supplement industry with ingredients sourced from South and southeast Asia.

I'm not saying curcumin doesnt have these benefits, I just would personally want to see this research reporduced in vivo by a researcher in Europe or the US or even South America before I took it at face value. I am sure there's a not of fat and obese people who take curcumin and do not seem to be losing any weight lol...

Hopefully this helps.
 
Biotest is a scam company.

That being said, I drink warm Golden Milk before bed...been doing it for years. Love the cinnamon and ginger taste with warm milk.
 
What is "Golden Milk" and what is its usefulness for the body?
It's just milk with Turmeric and usually some ginger or other spice for flavor. When heated rhe Turmeric binds to the first in the milk, causing it to be somewhat more bioavailable. I doubt it does much for the body compared a Turmeric or curcumin extract product though.

Also, somethings consider is that A1 casomorphin, which is a peptide in cow dairy product that strong activates the mu opioid receptor. Is also highly inflammatory in the gutband body. So this likely would mitigate any benefit the small dose of turmeric would have. You can avoid it by getting goat dairy products instead, or they have e bred cows to produce B1 Casomorphin instead of A1, which doesn't have the inflammatory properties. This milk is hard to find though.

Apparently A1 casomorphine has also been linked to other issues like insulin resistance, autoimmune reactions, and other stuff. This is why so many people feel so much better when they cut out dairy. Many think it's just lactose, but dairy insensitivity can be much more complex than that.
 
It's just milk with Turmeric and usually some ginger or other spice for flavor. When heated rhe Turmeric binds to the first in the milk, causing it to be somewhat more bioavailable. I doubt it does much for the body compared a Turmeric or curcumin extract product though.

Also, somethings consider is that A1 casomorphin, which is a peptide in cow dairy product that strong activates the mu opioid receptor. Is also highly inflammatory in the gutband body. So this likely would mitigate any benefit the small dose of turmeric would have. You can avoid it by getting goat dairy products instead, or they have e bred cows to produce B1 Casomorphin instead of A1, which doesn't have the inflammatory properties. This milk is hard to find though.

Apparently A1 casomorphine has also been linked to other issues like insulin resistance, autoimmune reactions, and other stuff. This is why so many people feel so much better when they cut out dairy. Many think it's just lactose, but dairy insensitivity can be much more complex than that.

Good point. And I've tried Golden Milk with warm almond milk, but for some reason the taste isn't the same to me. It just tastes so good with cows milk.
 
Without googling I am willing to bet on TC Luoma.
Lmao you are correct. Why do they even let that guy write on that site. There needs to be some bar of entry for who gets to write stuff like that and it should be high enough that this Luoma fails lol.
 
It's just milk with Turmeric and usually some ginger or other spice for flavor. When heated rhe Turmeric binds to the first in the milk, causing it to be somewhat more bioavailable. I doubt it does much for the body compared a Turmeric or curcumin extract product though.

Also, somethings consider is that A1 casomorphin, which is a peptide in cow dairy product that strong activates the mu opioid receptor. Is also highly inflammatory in the gutband body. So this likely would mitigate any benefit the small dose of turmeric would have. You can avoid it by getting goat dairy products instead, or they have e bred cows to produce B1 Casomorphin instead of A1, which doesn't have the inflammatory properties. This milk is hard to find though.

Apparently A1 casomorphine has also been linked to other issues like insulin resistance, autoimmune reactions, and other stuff. This is why so many people feel so much better when they cut out dairy. Many think it's just lactose, but dairy insensitivity can be much more complex than that.
This is very interesting, thank you for such a detailed and useful post, thank you.
 
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