First, right off the bat, I would like to make it clear that this is not my position. I personally believe that optimal levels of DHEA are important for their own sake, but do not believe that DHEA supplementation is feasible for a significant testosterone replacement therapy.
That said, this topic keeps coming up in certain quarters, with a lot of "support" for that position coming by way of a "Life Extension Foundation" article that keeps getting quoted:
http://www.lef.org/magazine/mag2002/aug2002_report_test_02.html
The specific section that is refered to is the following:
QUOTE
In some cases DHEA replacement seems sufficient to produce the benefits suggesting increased levels of free testosterone, even though total serum testosterone is unaffected (in women, total serum testosterone does rise after DHEA replacement). Fortunately, a well-controlled study published in the prestigious Journal of Clinical and Experimental Endocrinology and Metabolism did in fact find a significant rise in free testosterone in men aged 60 to 84 years, after three months on 100 mg of DHEA. There was no rise in total testosterone or in PSA. Even at lower doses of DHEA, one would expect a rise in tissue levels of testosterone, undetectable in the serum but nevertheless of considerable
END QUOTE
Those comments apparently are made based upon a "well-controlled study published in the prestigious Journal of Clinical and Experimental Endocrinology and Metabolism" that is as follows:
Flynn MA. DHEA replacement in aging humans. J Clin Exper Endocrinol Metabolism 1999; 84:1527-33.
I note that the article does not specifically quote or publish the actual study nor even provide a link to said study. Nor does the article address what happened with levels of estradiol (E2) or DHT, etc., etc. with prolonged supplementation of DHEA at the levels used in the study.
Is anyone familiar with that study? Can someone provide the actual quoted abstract of that study?
For example as is done at:
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=PubMed&list_uids=10372727&dopt=Abstract
That info - and any other info available that would refute the concept of DHEA (even high dose DHEA) being a viable form of TRT treatment - would be greatly appreciated!
Larry
That said, this topic keeps coming up in certain quarters, with a lot of "support" for that position coming by way of a "Life Extension Foundation" article that keeps getting quoted:
http://www.lef.org/magazine/mag2002/aug2002_report_test_02.html
The specific section that is refered to is the following:
QUOTE
In some cases DHEA replacement seems sufficient to produce the benefits suggesting increased levels of free testosterone, even though total serum testosterone is unaffected (in women, total serum testosterone does rise after DHEA replacement). Fortunately, a well-controlled study published in the prestigious Journal of Clinical and Experimental Endocrinology and Metabolism did in fact find a significant rise in free testosterone in men aged 60 to 84 years, after three months on 100 mg of DHEA. There was no rise in total testosterone or in PSA. Even at lower doses of DHEA, one would expect a rise in tissue levels of testosterone, undetectable in the serum but nevertheless of considerable
END QUOTE
Those comments apparently are made based upon a "well-controlled study published in the prestigious Journal of Clinical and Experimental Endocrinology and Metabolism" that is as follows:
Flynn MA. DHEA replacement in aging humans. J Clin Exper Endocrinol Metabolism 1999; 84:1527-33.
I note that the article does not specifically quote or publish the actual study nor even provide a link to said study. Nor does the article address what happened with levels of estradiol (E2) or DHT, etc., etc. with prolonged supplementation of DHEA at the levels used in the study.
Is anyone familiar with that study? Can someone provide the actual quoted abstract of that study?
For example as is done at:
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=PubMed&list_uids=10372727&dopt=Abstract
That info - and any other info available that would refute the concept of DHEA (even high dose DHEA) being a viable form of TRT treatment - would be greatly appreciated!
Larry
