MESO-Rx
Anabolic Steroids
Dimethylamylamine [DMAA]
- Thread starter Michael Scally MD
- Start date
Re: Jack3d and OxyElite Pro
Gregory PJ. Availability of DMAA Supplements Despite US Food and Drug Administration Action. Arch Intern Med.2012:1-2. JAMA Network | Archives of Internal Medicine | Availability of DMAA Supplements Despite US Food and Drug Administration Action
Gregory PJ. Availability of DMAA Supplements Despite US Food and Drug Administration Action. Arch Intern Med.2012:1-2. JAMA Network | Archives of Internal Medicine | Availability of DMAA Supplements Despite US Food and Drug Administration Action
Coroner rules marathoner cause of death = DMAA + extreme physical exertion
Read more: Marathon death: coroner warns of danger of legal stimulants - Telegraph
Read more: Marathon death: coroner warns of danger of legal stimulants - Telegraph
I have been a regular user of Ephedrine for years. I am quite used to the way it makes me feel and ensure I cycle on and off properly etc.
I bought a preworkout powder last year that contained DMAA and I gotta say this shit ramped me up beyond what ephedrine was capable of. I won't say I didn't like using it, in fact I was going to buy more recently until I saw they had changed the formula....but I do think it could be dangerous in terms of abuse potential moreso than Ephedrine is.
I bought a preworkout powder last year that contained DMAA and I gotta say this shit ramped me up beyond what ephedrine was capable of. I won't say I didn't like using it, in fact I was going to buy more recently until I saw they had changed the formula....but I do think it could be dangerous in terms of abuse potential moreso than Ephedrine is.
Pericles
New Member
Yes, I always hated the way epedra made me feel. However I love 1, 3, Di. (DMAA). All I want to do is train and I feel awesome. I just don't use more than the recommended dosage.
A Workout Booster, and a Lawsuit
http://www.nytimes.com/2013/02/14/business/death-after-use-of-jack3d-shows-gap-in-regulation.html
http://www.nytimes.com/2013/02/14/business/death-after-use-of-jack3d-shows-gap-in-regulation.html
Pericles
New Member
Had a customer come into my store (I sell lots of pre-workouts....my fav and biggest seller is Nitro NCG, awesome stuff).
He said he got a stabbing pain in his head while training. We went through his supps and gear use (he is on trt....at age 26, the result of starting gear at 19).
He said he took 2 full scoops of Nitro. 1 scoop is a dose, and will really, as you say, ramp you up. I rarely take more than 2/3rds of a scoop. I told him that 2 scoops is crazy, and if he kept abusing it he could well have a cerebral hemorrhage.
The bottom line is to be conservative. Don't take more than the recommended dose, and if it is no longer working, take at least 2 weeks off from using.
He said he got a stabbing pain in his head while training. We went through his supps and gear use (he is on trt....at age 26, the result of starting gear at 19).
He said he took 2 full scoops of Nitro. 1 scoop is a dose, and will really, as you say, ramp you up. I rarely take more than 2/3rds of a scoop. I told him that 2 scoops is crazy, and if he kept abusing it he could well have a cerebral hemorrhage.
The bottom line is to be conservative. Don't take more than the recommended dose, and if it is no longer working, take at least 2 weeks off from using.
now that DMAA has been found to be naturally occurring in geranium plants, do you think it will be legalized for OTC sales?
i personally don't like the tremendous crash i get after taking it. I literally feel like I'm made of lead and I can't move very fast. everything is in slow motion...kinda like when you're stoned lol.
i personally don't like the tremendous crash i get after taking it. I literally feel like I'm made of lead and I can't move very fast. everything is in slow motion...kinda like when you're stoned lol.
Pericles
New Member
I thought that the connection was still not proven?
I don't worry about the crash. Today was my day off, I slept, laid around the house while my wife (god bless her) cooked and did laundry. I spent some quality time w/ my son, wresting....tapping him w/ triangle cokes and arm bars.....he is 5, lol. We also had a few pillow fights.
So today, I only needed a cup of coffee before training. 3 days of the week, I lift hard core for an hour, do some yoga, and finish w/ the heavy bags for 20 minutes, a long, brutal work out. I also work on those days, so I need the pick up. I don't leave the gym until 8:15, go back and close my store, and get home at around 9:30-10. So, crashing is of no concern, in fact I usually don't go to bed until much later (sleep late, work late, train late).
Tue/Thurs Sat I do cardio and abs before going to work, so I don't need DMAA then either.
The bottom line is, don't abuse this stuff, be conservative w/ dosing.
I don't worry about the crash. Today was my day off, I slept, laid around the house while my wife (god bless her) cooked and did laundry. I spent some quality time w/ my son, wresting....tapping him w/ triangle cokes and arm bars.....he is 5, lol. We also had a few pillow fights.
So today, I only needed a cup of coffee before training. 3 days of the week, I lift hard core for an hour, do some yoga, and finish w/ the heavy bags for 20 minutes, a long, brutal work out. I also work on those days, so I need the pick up. I don't leave the gym until 8:15, go back and close my store, and get home at around 9:30-10. So, crashing is of no concern, in fact I usually don't go to bed until much later (sleep late, work late, train late).
Tue/Thurs Sat I do cardio and abs before going to work, so I don't need DMAA then either.
The bottom line is, don't abuse this stuff, be conservative w/ dosing.
Bigmdbeeze
New Member
Great info, very informative and a must read!
Stimulant Potentially Dangerous to Health, FDA Warns
http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm347270.htm
http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm347270.htm
Pericles
New Member
From the JOURNAL Nutrition and Metabolic Insights
Background: 1,3-dimethylamylamine is a commonly used ingredient within dietary supplements. Our prior work with this agent indicates a transient increase in blood pressure (systolic in particular) following oral ingestion of a single dosage, but no significant increase in resting blood pressure following chronic ingestion. Moreover, intervention studies involving both two and eight weeks of treatment with finished products containing 1,3-dimethylamylamine indicate minimal or no change in bloodborne markers of health. The present study sought to extend these findings by using a 10-week intervention trial to determine the change in selected markers of health in a sample of men.
Methods: 25 healthy men were randomly assigned to either a placebo (n = 13) or to a supplement containing 1,3-dimethylamylamine (n = 12) for a period of 10 weeks. Before and after the intervention, resting blood pressure and heart rate were measured, and blood samples were collected for determination of complete blood count, metabolic panel, and lipid panel.
Results: No significant differences were noted between conditions for blood pressure (P > 0.05), although systolic blood pressure increased approximately 6 mmHg with the supplement (diastolic blood pressure decreased approximately 4 mmHg). A main effect for time was noted for heart rate (P = 0.016), with values decreasing from pre to post intervention. There were significant main effects for time for creatinine (increased from pre to post intervention; P = 0.043) and alkaline phosphatase (decreased from pre to post intervention; P = 0.009), with no condition differences noted (P > 0.05). There was a significant interaction noted for low density lipoprotein cholesterol (LDL-C) (P = 0.043), with values decreasing in the supplement group from pre to post intervention approximately 7 mg • dL-1 (P = 0.034). No other effects of significance were noted for bloodborne variables.
Conclusion: These data indicate that a dietary supplement containing 1,3-dimethylamylamine does not result in a statistically significant increase in resting heart rate or blood pressure (although systolic blood pressure is increased ~6 mmHg with supplement use). The supplement does not negatively impact bloodborne markers of health. Further study is needed involving a longer intervention period, a larger sample size, and additional measures of health and safety.
My Take:: Granted, the # of participant were limited, but the P score for blood pressure was robust (greater than .05) so we cannot reject the null hypothesis (that there is no relationship between two measured phenomena,[
Background: 1,3-dimethylamylamine is a commonly used ingredient within dietary supplements. Our prior work with this agent indicates a transient increase in blood pressure (systolic in particular) following oral ingestion of a single dosage, but no significant increase in resting blood pressure following chronic ingestion. Moreover, intervention studies involving both two and eight weeks of treatment with finished products containing 1,3-dimethylamylamine indicate minimal or no change in bloodborne markers of health. The present study sought to extend these findings by using a 10-week intervention trial to determine the change in selected markers of health in a sample of men.
Methods: 25 healthy men were randomly assigned to either a placebo (n = 13) or to a supplement containing 1,3-dimethylamylamine (n = 12) for a period of 10 weeks. Before and after the intervention, resting blood pressure and heart rate were measured, and blood samples were collected for determination of complete blood count, metabolic panel, and lipid panel.
Results: No significant differences were noted between conditions for blood pressure (P > 0.05), although systolic blood pressure increased approximately 6 mmHg with the supplement (diastolic blood pressure decreased approximately 4 mmHg). A main effect for time was noted for heart rate (P = 0.016), with values decreasing from pre to post intervention. There were significant main effects for time for creatinine (increased from pre to post intervention; P = 0.043) and alkaline phosphatase (decreased from pre to post intervention; P = 0.009), with no condition differences noted (P > 0.05). There was a significant interaction noted for low density lipoprotein cholesterol (LDL-C) (P = 0.043), with values decreasing in the supplement group from pre to post intervention approximately 7 mg • dL-1 (P = 0.034). No other effects of significance were noted for bloodborne variables.
Conclusion: These data indicate that a dietary supplement containing 1,3-dimethylamylamine does not result in a statistically significant increase in resting heart rate or blood pressure (although systolic blood pressure is increased ~6 mmHg with supplement use). The supplement does not negatively impact bloodborne markers of health. Further study is needed involving a longer intervention period, a larger sample size, and additional measures of health and safety.
My Take:: Granted, the # of participant were limited, but the P score for blood pressure was robust (greater than .05) so we cannot reject the null hypothesis (that there is no relationship between two measured phenomena,[
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FDA Deploys Section 301(ll) in Battle Against DMAA
FDA Law Blog: FDA Deploys Section 301(ll) in Battle Against DMAA
FDA Law Blog: FDA Deploys Section 301(ll) in Battle Against DMAA
Austin KG, Travis J, Pace G, Lieberman HR. Analysis of 1,3 dimethylamylamine concentrations in Geraniaceae, geranium oil and dietary supplements. Drug Testing and Analysis. Analysis of 1,3 dimethylamylamine concentrations in Geraniaceae, geranium oil and dietary supplements - Austin - 2013 - Drug Testing and Analysis - Wiley Online Library
1,3-Dimethylamylamine (DMAA) is a sympathomimetic compound currently incorporated into some dietary supplements. Significant controversy exists regarding the ‘natural’ origin of DMAA, as claimed by manufacturers of supplements. Manufacturers often refer to its presence by the name Geranamine® implying that DMAA is found in the plant species Geranium and Pelargonium known collectively as Geraniaceae. This study determined whether DMAA is present in the plant species, Geranium and Pelargonium. In addition, concentrations of DMAA in popular dietary supplements and commercial Geranium and Pelargonium oils were assessed. One Pelargonium cultivar, one Geranium cultivar, three essential oils from Pelargonium or Geranium, raw DMAA powder, and seven dietary supplements (DS) sold as finished products and labelled as containing DMAA, or one of its synonyms, were analyzed for the presence of DMAA by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). No measurable levels of DMAA in Geranium, Pelargonium or essential oils at a detection limit of 1–2?ng/g were present. UPLC/MS/MS analysis confirmed the presence of DMAA in spiked plant and oil samples, all seven DS products, and raw DMAA powder. Concentrations (weight%) of DMAA provided in DS ranged from 0.11% to 673%. This study indicates DMAA contained in DS is of a synthetic origin and is not present in the plant species Geranium and Pelargonium; thus the ‘natural’ origin and use of DMAA as an ingredient in DS is not substantiated.
1,3-Dimethylamylamine (DMAA) is a sympathomimetic compound currently incorporated into some dietary supplements. Significant controversy exists regarding the ‘natural’ origin of DMAA, as claimed by manufacturers of supplements. Manufacturers often refer to its presence by the name Geranamine® implying that DMAA is found in the plant species Geranium and Pelargonium known collectively as Geraniaceae. This study determined whether DMAA is present in the plant species, Geranium and Pelargonium. In addition, concentrations of DMAA in popular dietary supplements and commercial Geranium and Pelargonium oils were assessed. One Pelargonium cultivar, one Geranium cultivar, three essential oils from Pelargonium or Geranium, raw DMAA powder, and seven dietary supplements (DS) sold as finished products and labelled as containing DMAA, or one of its synonyms, were analyzed for the presence of DMAA by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). No measurable levels of DMAA in Geranium, Pelargonium or essential oils at a detection limit of 1–2?ng/g were present. UPLC/MS/MS analysis confirmed the presence of DMAA in spiked plant and oil samples, all seven DS products, and raw DMAA powder. Concentrations (weight%) of DMAA provided in DS ranged from 0.11% to 673%. This study indicates DMAA contained in DS is of a synthetic origin and is not present in the plant species Geranium and Pelargonium; thus the ‘natural’ origin and use of DMAA as an ingredient in DS is not substantiated.
novicebb
New Member
Its funny that many of you say DMAA gives you similar effects to ephedrine because I feel the complete opposite.
I personally love DMAA. I have taken it on and off for over 2 years. Mostly took it because of the "true alert" feeling it gave me. I work 12 hour shifts 3-4 days straight a week and barely got 4 hours sleep during those days. W/o DMAA I know I wouldn't have been able to make it on such a work schedule for almost 2 years.
I definitely concentrate better with DMAA but I don't get a stimulant feeling or even a feeling of energy with it like I do with an ECA stack. I don't feel jittery or like my heart is racing.
I can take a stimulant like Ephedrine with Caffeine, Clenbuteral and feel like I have all the energy in the world but still feel sleepy, groggy and unfocused.
I guess it effects me differently then others. In my personal esperience, DMAA is definitely not habit forming. I usually only take it on days I work and one 25mg capsule lasts me more than half the day so I never take it before a workout or rarely on my off days so maybe that is why I feel I haven't had any negative side effects
I personally love DMAA. I have taken it on and off for over 2 years. Mostly took it because of the "true alert" feeling it gave me. I work 12 hour shifts 3-4 days straight a week and barely got 4 hours sleep during those days. W/o DMAA I know I wouldn't have been able to make it on such a work schedule for almost 2 years.
I definitely concentrate better with DMAA but I don't get a stimulant feeling or even a feeling of energy with it like I do with an ECA stack. I don't feel jittery or like my heart is racing.
I can take a stimulant like Ephedrine with Caffeine, Clenbuteral and feel like I have all the energy in the world but still feel sleepy, groggy and unfocused.
I guess it effects me differently then others. In my personal esperience, DMAA is definitely not habit forming. I usually only take it on days I work and one 25mg capsule lasts me more than half the day so I never take it before a workout or rarely on my off days so maybe that is why I feel I haven't had any negative side effects
I miss ephedrine over OTC stimulants that followed.
ephedrine, was my favorite too it was the only thing that got me threw work when I worked at Dr. Pepper. But 1,3-dimethylamylamine is good in moderate amount. I think its like anything in moderation. you wouldn't run a race in the heat on cocaine.
Agreed. All the crap out there today is either worthless, noxious, ineffective for the purpose, or just downright nasty. The ones that actually have an effect also seem to be even more risky than the old ephedrine. Funny how they went and got aggressive and pulled one that no one really gave a crap about, and really did not have all that dangerous a reputation, and now all this garbage out there. That ephedrine was a "good clean pickup" in correct moderation, and a really good thermogenic I understand. I really could not stand it for very long either as it left me PHYSICALLY exhausted the next morning, and way more so than amphetamines ever did/do...
DMAA in Dietary Supplements
http://www.fda.gov/Food/DietarySupplements/QADietarySupplements/ucm346576.htm
DMAA in Dietary Supplements - DMAA, also known as 1,3-dimethylamylamine, methylhexanamine or geranium extract, is an ingredient found illegally in some dietary supplements and often touted as a “natural” stimulant. On July 2, 2013, as a result of follow-up legal action by FDA, the dietary supplement firm USPlabs voluntarily destroyed its DMAA-containing products located at its facility in Dallas, Texas. USPlabs agreed to destroy the products after FDA administratively detained them under the Federal Food, Drug and Cosmetic Act, recently amended by the Food Safety Modernization Act (FSMA).
http://www.fda.gov/Food/DietarySupplements/QADietarySupplements/ucm346576.htm
DMAA in Dietary Supplements - DMAA, also known as 1,3-dimethylamylamine, methylhexanamine or geranium extract, is an ingredient found illegally in some dietary supplements and often touted as a “natural” stimulant. On July 2, 2013, as a result of follow-up legal action by FDA, the dietary supplement firm USPlabs voluntarily destroyed its DMAA-containing products located at its facility in Dallas, Texas. USPlabs agreed to destroy the products after FDA administratively detained them under the Federal Food, Drug and Cosmetic Act, recently amended by the Food Safety Modernization Act (FSMA).
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