DNP boost in relation to dose?

[synergy317]

I was very curious if the relationship between body concetration and actual effect. Taking 600 mg daily will give a concetration of around 900 - 1000 mg. While a 400mg daily dose gives 650 mg. (Assuming 36 hour halflife). So does anyone know of any study that shows the relationship of % metabolic boost and concentration?

 

[OatsNhoes]

I've read Conc say in other threads that every 100mg is a 10% boost in metabolic rate, as a general rule of thumb.

For example 200mg/ed dose would be a20% incrase in BMR, but that is after a few days, when dnp has reached it's max concentration in your system.

 

[Lizard King]

I think he also said that the increase in dose does not proportionally increase the metabolic rate.

 

[OatsNhoes]

I think he also said that the increase in dose does not proportionally increase the metabolic rate.

Weird... I thought he said it does.

 

[Conciliator]

I've read Conc say in other threads that every 100mg is a 10% boost in metabolic rate, as a general rule of thumb.

According to the original clinical research (Cutting and Tainter's work), every 100mg of crystal DNP per day will increase metabolic rate an average of 11%. Note that this is only an average. Individual sensitivity to it will vary greatly. Also, this assumes crystal DNP content (powder DNP, which is stronger, is about 15% per 100mg). Finally, this already takes into account the long half-life and indicates the increase in metabolic rate after the drug accumulates (so after 3-5 days at a given dose).

So, for example, a daily dose 400mg of powder DNP (after it accumulates) will increase metabolic rate an average of 60%. 400mg/day of crystal DNP will increase metabolic rate an average of 44%.

 

[Conciliator]

I think he also said that the increase in dose does not proportionally increase the metabolic rate.

I don't think I said that. It appears to be pretty proportional. Here's an image constructed from the actual clinical data (based on crystal DNP).

Embedded Image Unvailable

Also, if you're wondering why the 500mg/day group was found to have a reduced effect compared to the 400mg/day group, it's because the higher dose was only used in those who were tolerant to the lower doses. Thus, it underestimates the increase in metabolic rate and weight loss for a person of average tolerance to DNP.

 

[Lizard King]

Sorry for the mis-quote, I thought I had read that in one of your posts.

Thank you for the chart.

 

[bigollie2006]

I don't think I said that. It appears to be pretty proportional. Here's an image constructed from the actual clinical data (based on crystal DNP).

Embedded Image Unvailable

Also, if you're wondering why the 500mg/day group was found to have a reduced effect compared to the 400mg/day group, it's because the higher dose was only used in those who were tolerant to the lower doses. Thus, it underestimates the increase in metabolic rate and weight loss for a person of average tolerance to DNP.

If you have a link to where you got this graph I would much appreciate it if you posted for me

 

[Conciliator]

If you have a link to where you got this graph I would much appreciate it if you posted for me

The image comes from Clapham JC. Treating obesity: pharmacology of energy expenditure. Curr Drug Targets. 2004 Apr;5(3):309-23.
Abstract: Treating obesity: pharmacology of energy expenditu... [Curr Drug Targets. 2004] - PubMed result
Full text: [ame]http://rapidshare.com/files/425307103/Treating_Obesity_-_Pharmacology_of_Energy_Expenditure.pdf[/ame]

The underlying data for the image comes from Tainter, M. L.; Stockton, A. B. and Cutting, W. C. Dinitrophenol in the treatment of obesity: Final Report. J Am Med Assoc. 1935;105(5):332-337.
Excerpt: http://jama.ama-assn.org/cgi/content/summary/105/5/332

-Conciliator

 

[bigollie2006]

The image comes from Clapham JC. Treating obesity: pharmacology of energy expenditure. Curr Drug Targets. 2004 Apr;5(3):309-23.
Abstract: Treating obesity: pharmacology of energy expenditu... [Curr Drug Targets. 2004] - PubMed result
Full text: http://rapidshare.com/files/425307103/Treating_Obesity_-_Pharmacology_of_Energy_Expenditure.pdf

The underlying data for the image comes from Tainter, M. L.; Stockton, A. B. and Cutting, W. C. Dinitrophenol in the treatment of obesity: Final Report. J Am Med Assoc. 1935;105(5):332-337.
Excerpt: J Am Med Assoc -- Excerpt: DINITROPHENOL IN THE TREATMENT OF OBESITY: FINAL REPORT, August 3, 1935, TAINTER et al. 105 (5): 332

-Conciliator

You sir are an angel

 

[dantank]

The image comes from Clapham JC. Treating obesity: pharmacology of energy expenditure. Curr Drug Targets. 2004 Apr;5(3):309-23.
Abstract: Treating obesity: pharmacology of energy expenditu... [Curr Drug Targets. 2004] - PubMed result
Full text: http://rapidshare.com/files/425307103/Treating_Obesity_-_Pharmacology_of_Energy_Expenditure.pdf

The underlying data for the image comes from Tainter, M. L.; Stockton, A. B. and Cutting, W. C. Dinitrophenol in the treatment of obesity: Final Report. J Am Med Assoc. 1935;105(5):332-337.
Excerpt: J Am Med Assoc -- Excerpt: DINITROPHENOL IN THE TREATMENT OF OBESITY: FINAL REPORT, August 3, 1935, TAINTER et al. 105 (5): 332

-Conciliator

Conciliator, thanks for that document.

Can you possibly post your stockpile of research documents?



They seem very hard to come by.

 

[synergy317]

Thanks a lot for the info. Good Stuff

 

[xxjaredxx]

According to the original clinical research (Cutting and Tainter's work), every 100mg of crystal DNP per day will increase metabolic rate an average of 11%. Note that this is only an average. Individual sensitivity to it will vary greatly. Also, this assumes crystal DNP content (powder DNP, which is stronger, is about 15% per 100mg). Finally, this already takes into account the long half-life and indicates the increase in metabolic rate after the drug accumulates (so after 3-5 days at a given dose).

So, for example, a daily dose 400mg of powder DNP (after it accumulates) will increase metabolic rate an average of 60%. 400mg/day of crystal DNP will increase metabolic rate an average of 44%.

This is interesting. So if I am using a souce that utiliztes Crystal (the same guy I've always used) - and I were to go on a 3 Capsule regimen (750 mg), this would yield an approximate average metabolic increase of 82.5% (750/100*11)