DNP- honest review

[loveyourbody]

Hey guys long time no post been really busy! But, I recently did 2 DNP cycle one with the worst side effect of my life and one with only feeling hot as my side effect. So, I wanted to make this thread and inform people on proper use of DNP
Cycle 1
Starting stats
5'5
197lb
Around 19% body fat I guess not sure but no six pack just the out side linings lol
Ok I was writing down on a journal so I will just breaf it because its a lot of info and I hope it helps a few people out there
-I used DNP crystal 250mg casuals from a legit source(took them each with the meal)
-A clean diet
- and low cardio


Day-1
Took one 250mg
Nothing
2 gallons of water
Day-2
Took one 250mg
Slight random heat flashes
2.1 gallons of water

Day-3
Took one 250mg
Feel slightly hotter, a few more random hot flashes, and a mild headache
2 gallons

Day 4
Took 500mg 1 in the morning and one around 3pm
Last night was hard to sleep kept waking up feeling super got not sweating but really hot. Had a headache that wouldn't go away and felt like vomiting while having a mild stomach ache as well
Did intense cardio at the gym for an hour then went into the stem room. After being in for about 3min felt so hot that I had to get out and get into freezing cold water and even then still felt super hot.
2 gallons

Day 5
I took 500mg once I gain split am and pm
No cardio, just went to work and went straight home took the pills with no food and had only 1 cup of water did not feel dehydrated. Had felt hot, headache, like vomiting, and stomach pain.
1-2cups of water

Day 6
Droped back down to 250mg
Couldn't sleep kept waking up every few min. Ether because I was hot, stomach pain, or because diarrhea. I called out of work and slept all day I mean from 11pm the night before too 9pm today. But I kept waking up because of the disconcert.
2.3 gallons of water

Day 7
I stopped taking them I have black stool(black diarrhea because bleeding in the stomach), severely dehydrated from the high body temp, and the diarrhea. Also started getting and allergic reaction and got an itchy rash all over my legs, back, chest, and scalp.

Day 8
My friend took me too the doctor. He ask me questions but I was so dehydrated I couldn't look straight and kept answering with random shit I mean random. So I went to the doctor they did blood work and everything came back good. But, since I was so dehydrated they out me on I.V fluid. After and hour I was fully aware of my surroundings again. She told me to take Benadryl for the rash and it would be gone in a week or two.

So I thought it was finally over but boy was I wrong the worst was yet to come...

Day 9
Just itchy

Day 10
Just itchy

Day 11
I was sleeping and around 3am I woke up holding my hand wanting to scream out in pain from 1-10 of the worst pain I have felt I would give it a solid 7.8 it felt like some one had just kept breaking my fingers and the pain would not go away. Eventually it subsided but the pain was around a 3 all next day

Day 12
Once again around 2:39am the pain came back so bad I could not stand it got up went to Walgreens got some asprin and Ben-gay
Took 3 asprin and Ben-gay all over my hads to numb the pain and too 2 Benadryl to fall back asleep

Day 13
No pain during the day but once again at night had the worst pain yet I would give it a 8.5 it almost made me cry honestly that how bad the pain was I got up and walked around and actually put my hands and super hot water just to feel a different kind of pain. Once again took the Benadryl, asprin, and Ben gay and passed out. Out of no where I had no nerve pain the next day and I thought it was finally over but no...

Day 14
Woke up feeling even worst nerve pain but this time in my toes from 1-10 I would give it a 9.
Till
Day 19
The nerve pain in my feet was so bad I couldn't stand for more than 10mins without having to sit down. I had made up my mind that if It doesn't get better by tomorrow I am going to the doctor. I have not had more than 4 hours of sleep because of the pain. "To give you an example of how bad the pain was and I'm not lieing here... i made up my mind if they told me it was permanent nerve damage that I would tell them to amputate my toes"

Luckily 2 days later it went away

I'm only writing this review on here because honestly I don't want anyone to go through that kind of pain my girlfriend thought I was going to die and honestly the doctor said 2 more days like I was and I wouldn't be here
This baby needs to be treated with respect.
End result
182lb but I lost some muscle

Now on cycle number two which I did 2 months later it went much better
Start stats
185lb
I took lots of precaughtions
1-vitamins( 1 pill every day)
1-v8( a whole small bottle)
1-small Gatorade to help prevent diarrhea
3-gallons of water a day
1-gallon of water per hour of workout
- take the DNP with meal never alone
-starting day 4 take Benadryl to help prevent allergic reaction and help sleep

Day 1- 1 pill nothing

Day 2- 1 pill mild heat flashes

Day 3- 1 pill warm all day but nothing I could handle

Day 4- 500mg split warm but nothing I couldn't handle

Day 5- 500mg split hot all day. Was really hot all night but slept with a fan blowing in my face so slept like a baby

Day 6- 500mg spilt hot all day and night woke up and my sheets where damp but not super wet like some people clam( weighed my self 179)

Day 7- 500mg split last day super hot but keep drinking cold water so it bring my temp back down. Bed was damp once again but not super bad. Weight myself and reached my goal of 175lb.

Followed my precautions for day8-12 just to make sure none of the nerve pain would happen because to be honest I was scared to feel that pain I would gladly get shot instead of the nerve pain. But, luckily with all the precautions I took in the secound cycle was only increase temp. Other than that I was good to go.

So if you plan to go on a DNP cycle please follow these rules

200-250mg for the first 3-4 days
Drink at least 3 gallons of water
Take DNP with a meal
Gatorade to help with diarrhea
V8 for the potassium
Benadryl to avoid allergic reaction
Avoid hot places example steam room
ONLY USE DNP IF YOU ARE EXPERIENCED( I have 6 steriods cycle under my belt, 9 years of weight lifting, and 3DNP cycle) they do work but it can kill my friends
And if you feel sick like I was don't wait and just go to the doctor!!!!

Well I hopes this helps some people and if you guys have any questions I would be more than happy answer them.

 

[whitegato777]

I've taken it more than 6 time in Arizona heat and have nothing so far to complain about.

 

[Tiny]

The results and sides aren't the same for everyone. I just got off a three week run of dnp to hit 8% body fat down from 21% in a month. About 18lbs of raw fat in 3 weeks. I honestly just can't get below 10% without it unless I starve. What were my sides? Nothing except some sweat.

What was my dose? Actually I decided to cut the games and the slow build up period of ~7 days and frontload 8 caps the first day to hit the 1600mg~ "working" 600mg dose. I ran 68 caps total in 21 days. Sounds like a suicide dose? I felt nothing at all except a constant sweat, if I had felt anything else I might have backed off. With the working frontload I was in the zone on day 1, not day 7 which attributed to a much shorter run overall and pills saved.

Were the cap's underdosed instead of 250mg? Only Dinitro knows for sure, I dunno how to measure all that!

So to me, DNP works. Not that I plan to use it regularly, but pre-cycle when I should be as lean as possible, yes sir, nothing else comes close. My next decision would be rather I choose to cut with DNP before my next cycle in 2014 or add some Tren.

*For op: According to an old post Conc had, it's NOT wise to drink V8 on DNP. Something about how Potassium synthesis can not be completed due to the chemical's cellular interference, so you either get your K before or after a burst, not during as it can build up and lead to K poisoning.

 

[Dr JIM]

The underlying mechanism for the avoidance of "high K" food stuffs MAY be the following; Since DNP "uncouples mitochondrial oxidative phosphorylation" cellular energy production (ATP) and availability are also reduced.

Under normal physiologic conditions the "potassium/ATPase pump" drastically increases the intracellular/extracellular POTASSIUM gradient achieving a much HIGHER intracellular potassium concentration.

This "gradient" is utilized as a FUNDAMENTAL and OBLIGATORY ionic energy source for a variety of metabolic functions, from transcellular transport to intracellular anabolic processes.

Nonetheless since DNP decreases net ATP production and markedly increases cellular entropy, whatever ATP is available may become insufficient to maintain the K/ATP pump allowing potassium "to leak" out of the and into the interstitial space, towards intracellular/extracellular equilibrium.

However whenever OP becomes so limited as to hamper the "potassium pump" gradient, (as noted by an increased potassium level), cellular DEATH is imminent.

Ergo If someone's using POTASSIUM in any way to determine the effectiveness, dosing, or optimal management of DNP, I would run as far and as fast as is humanly possible, because the next time you see THAT gent may be in a coffin.

(I'm NOT going to further elaborate on the inherent dangers of DNP use)

Suffice it to say I do hope those whom choose to use this drug obtain and intensively review as much evidence as possible, and would implore said "users" to exercise the utmost in caution and due diligence before even considering DNP as a viable "weight loss" option.

Best
Jim

 

[nlb27]

Excellent scientific explanation of the physiology behind the action of DNP Jim. Thank you.

 

[Mr. Joe]

Just to add to Dr Jim's commentary, I would be worried more about extracellular K concentration within the myocardium even before cell death. Na/K ATPase helps establish the necessary concentration gradients across cardiac muscle cells (and skeletal muscle, and neurons, and everything else) when that pump stops working as efficiently as it's supposed to Na builds up in the cell and K builds outside the cell.

What this means for excitable cells is that they become excited much easier leading to erratic cardiac events, as well as abnormal neuronal firing. Adding excess K to your diet will exacerbate these effects by increasing extracellular K even more.

 

[PillarofBalance]

Hey guys long time no post been really busy! But, I recently did 2 DNP cycle one with the worst side effect of my life and one with only feeling hot as my side effect. So, I wanted to make this thread and inform people on proper use of DNP
Cycle 1
Starting stats
5'5
197lb
Around 19% body fat I guess not sure but no six pack just the out side linings lol
Ok I was writing down on a journal so I will just breaf it because its a lot of info and I hope it helps a few people out there
-I used DNP crystal 250mg casuals from a legit source(took them each with the meal)
-A clean diet
- and low cardio


Day-1
Took one 250mg
Nothing
2 gallons of water
Day-2
Took one 250mg
Slight random heat flashes
2.1 gallons of water

Day-3
Took one 250mg
Feel slightly hotter, a few more random hot flashes, and a mild headache
2 gallons

Day 4
Took 500mg 1 in the morning and one around 3pm
Last night was hard to sleep kept waking up feeling super got not sweating but really hot. Had a headache that wouldn't go away and felt like vomiting while having a mild stomach ache as well
Did intense cardio at the gym for an hour then went into the stem room. After being in for about 3min felt so hot that I had to get out and get into freezing cold water and even then still felt super hot.
2 gallons

Day 5
I took 500mg once I gain split am and pm
No cardio, just went to work and went straight home took the pills with no food and had only 1 cup of water did not feel dehydrated. Had felt hot, headache, like vomiting, and stomach pain.
1-2cups of water

Day 6
Droped back down to 250mg
Couldn't sleep kept waking up every few min. Ether because I was hot, stomach pain, or because diarrhea. I called out of work and slept all day I mean from 11pm the night before too 9pm today. But I kept waking up because of the disconcert.
2.3 gallons of water

Day 7
I stopped taking them I have black stool(black diarrhea because bleeding in the stomach), severely dehydrated from the high body temp, and the diarrhea. Also started getting and allergic reaction and got an itchy rash all over my legs, back, chest, and scalp.

Day 8
My friend took me too the doctor. He ask me questions but I was so dehydrated I couldn't look straight and kept answering with random shit I mean random. So I went to the doctor they did blood work and everything came back good. But, since I was so dehydrated they out me on I.V fluid. After and hour I was fully aware of my surroundings again. She told me to take Benadryl for the rash and it would be gone in a week or two.

So I thought it was finally over but boy was I wrong the worst was yet to come...

Day 9
Just itchy

Day 10
Just itchy

Day 11
I was sleeping and around 3am I woke up holding my hand wanting to scream out in pain from 1-10 of the worst pain I have felt I would give it a solid 7.8 it felt like some one had just kept breaking my fingers and the pain would not go away. Eventually it subsided but the pain was around a 3 all next day

Day 12
Once again around 2:39am the pain came back so bad I could not stand it got up went to Walgreens got some asprin and Ben-gay
Took 3 asprin and Ben-gay all over my hads to numb the pain and too 2 Benadryl to fall back asleep

Day 13
No pain during the day but once again at night had the worst pain yet I would give it a 8.5 it almost made me cry honestly that how bad the pain was I got up and walked around and actually put my hands and super hot water just to feel a different kind of pain. Once again took the Benadryl, asprin, and Ben gay and passed out. Out of no where I had no nerve pain the next day and I thought it was finally over but no...

Day 14
Woke up feeling even worst nerve pain but this time in my toes from 1-10 I would give it a 9.
Till
Day 19
The nerve pain in my feet was so bad I couldn't stand for more than 10mins without having to sit down. I had made up my mind that if It doesn't get better by tomorrow I am going to the doctor. I have not had more than 4 hours of sleep because of the pain. "To give you an example of how bad the pain was and I'm not lieing here... i made up my mind if they told me it was permanent nerve damage that I would tell them to amputate my toes"

Luckily 2 days later it went away

I'm only writing this review on here because honestly I don't want anyone to go through that kind of pain my girlfriend thought I was going to die and honestly the doctor said 2 more days like I was and I wouldn't be here
This baby needs to be treated with respect.
End result
182lb but I lost some muscle

Now on cycle number two which I did 2 months later it went much better
Start stats
185lb
I took lots of precaughtions
1-vitamins( 1 pill every day)
1-v8( a whole small bottle)
1-small Gatorade to help prevent diarrhea
3-gallons of water a day
1-gallon of water per hour of workout
- take the DNP with meal never alone
-starting day 4 take Benadryl to help prevent allergic reaction and help sleep

Day 1- 1 pill nothing

Day 2- 1 pill mild heat flashes

Day 3- 1 pill warm all day but nothing I could handle

Day 4- 500mg split warm but nothing I couldn't handle

Day 5- 500mg split hot all day. Was really hot all night but slept with a fan blowing in my face so slept like a baby

Day 6- 500mg spilt hot all day and night woke up and my sheets where damp but not super wet like some people clam( weighed my self 179)

Day 7- 500mg split last day super hot but keep drinking cold water so it bring my temp back down. Bed was damp once again but not super bad. Weight myself and reached my goal of 175lb.

Followed my precautions for day8-12 just to make sure none of the nerve pain would happen because to be honest I was scared to feel that pain I would gladly get shot instead of the nerve pain. But, luckily with all the precautions I took in the secound cycle was only increase temp. Other than that I was good to go.

So if you plan to go on a DNP cycle please follow these rules

200-250mg for the first 3-4 days
Drink at least 3 gallons of water
Take DNP with a meal
Gatorade to help with diarrhea
V8 for the potassium
Benadryl to avoid allergic reaction
Avoid hot places example steam room
ONLY USE DNP IF YOU ARE EXPERIENCED( I have 6 steriods cycle under my belt, 9 years of weight lifting, and 3DNP cycle) they do work but it can kill my friends
And if you feel sick like I was don't wait and just go to the doctor!!!!

Well I hopes this helps some people and if you guys have any questions I would be more than happy answer them.

Your sides other than heat likely had nothing to do with DNP. I have eaten a hundred or more caps of DNP in my life. With meals, without meals it makes no difference.

And why would you think getting into a steam shower would be a bright idea while on DNP? Hello, McFly???

3 gallons of water is excessive. 2 is the max that anyone would need. At 750mg of crystal DNP 2 gallons was plenty.

 

[loveyourbody]

PillarOfBalance- i didn't not think dnp was as dangerous as people made it out to be. Sadly I had to find out the hard way. Well believe it or not those side effects happen. I rather be honest so people are a little bit more careful.
As for the steam shower i don't know what the hell I was thinking.

But, I can control what happens with other people all I know is I will never run dnp again.

 

[Dr JIM]

Many people SUED over the very symptoms you described PB.

Most use DNP for a few pounds of weight loss which inevitably returns. Risk benefit ratio for DNP is astronomically high with the risk for outweighing the benefits.

Thx
PB

 

[nlb27]

Dr Jim, Do you have an explanation as to why all the body fluids turn yellow? Scientifically I mean? Like the sclera of the eyes also?

 

[biggerben69]

Dr Jim, Do you have an explanation as to why all the body fluids turn yellow? Scientifically I mean? Like the sclera of the eyes also?

I know the industrial powder dnp, which is the only type I've run, is used as a dye in some things. It stains everything yellow. It's recommended that you cap the stuff and even open the bottle away from anything you don't want to possibly be stained.
You may think you're being real careful but the dust you can't really see will get ya.
I used to put the dose of dnp inside a slightly warmed starburst that I'd roll into sort of a ball and chase with a drink. Some of the powder would get out and stain my tongue.
Is the crystal stuff the same way? I've had d's caps in my possession but fagged out taking them. For some reason I think it is? I think I remember the inside of the white plastic bottle being stained. I hate the Yellow Devil...but it works as advertised.

 

[Mr. Joe]

Very simple nlb, dnp is yellow. It permeates all of the those cells that are turning yellow.

 

[nlb27]

Thanks Mr Joe... So eyes turning yellow= having negative effects on the eyes?

 

[biggerben69]

Thanks Mr Joe... So eyes turning yellow= having negative effects on the eyes?

Did the whites of the eyes turning yellow happen to you? Did somebody else here say that happened to them? I'll go back and read the thread. I don't believe I've ever heard that before? My memory isn't what it was once, though.
The only thing I remember being said as far as the eyes go was a small percentage of women reporting cataracs(sp?)......just females though?
I know you guys know that yellowing of the eyes is usually a liver issue. Jaundice scirrosis(sp...again!) I can tell you guys are more book smart than I am.

 

[nlb27]

Did the whites of the eyes turning yellow happen to you? Did somebody else here say that happened to them? I'll go back and read the thread. I don't believe I've ever heard that before? My memory isn't what it was once, though.
The only thing I remember being said as far as the eyes go was a small percentage of women reporting cataracs(sp?)......just females though?
I know you guys know that yellowing of the eyes is usually a liver issue. Jaundice scirrosis(sp...again!) I can tell you guys are more book smart than I am.

Indeed...yellowing of the sclera of the eyes indicates liver disease however, this is possibly not the cause of it when taking DNP saying as all of the bodily fluids tend to change colour too. My theory was it was a pigmentation issue due to the colour of DNP but I thought I'd check other peoples ideas about this...my eyes have started to turn yellowish in colour.

 

[Dr JIM]

I'll GIVE YOU AN HONEST REVIEW OF THE LITERATURE!

FOR THOSE CONSIDERING THE USE OF DNP, PLEASE READ THE FOLLOWING CITATION, WHICH IS AN EXCELLENT SUMMARY OF THE HUGE RISKS YOUR TAKING!

 

[Dr JIM]

Hmm, turns things "yellow" including the sclera?

Is this your personal observation, based on a documented case
report, anecdotes from others or evidence based literature?

Since dyes stain the "outside" of cells they should NOT cause JAUNDICE!

DNP However had been well established as a "cholestatic" agent and prevents the metabolism of BILE.

Consequently although some dyes may cause skin discoloration, a good example is beta carotene, they do NOT have ocular pigmentary effects UNLESS bilirubin metabolism is effected also.

Ergo the reason DNP is associated with jaundice "yellow" eyes is liver dysfunction, another well documented complication of DNP use.

Jim

 

[Dr JIM]

For those of you willing to discount or discredit Beezil's report of cataracts because of DNP use, the literature is UNEQUIVOCAL there is a STRONG association between DNP use and cataract formation, SECOND ONLY TO DIABETES!

So the next time your LOOKING at the floor squatting a "personal best", be happy your not using DNP. .

 

[CensoredBoardsSuck]

I'll GIVE YOU AN HONEST REVIEW OF THE LITERATURE!

FOR THOSE CONSIDERING THE USE OF DNP, PLEASE READ THE FOLLOWING CITATION, WHICH IS AN EXCELLENT SUMMARY OF THE HUGE RISKS YOUR TAKING!

Excellent article on the history of DNP, Dr Jim. For anybody that's considering its use, it's well worth the read.

Here's the abstract and a few excerpts.


Abstract

In the early 1930s, the industrial chemical dinitrophenol found widespread favor as a weight-loss drug, due principally to the work of Maurice Tainter, a clinical pharmacologist from Stanford University. Unfortunately the compound’s therapeutic index was razor thin and it was not until thousands of people suffered irreversible harm that mainstream physicians realized that dinitrophenol’s risks outweighed its benefits and abandoned its use. Yet, it took passage of the Food, Drug, and Cosmetic Act in 1938 before federal regulators had the ability to stop patent medicine men from selling dinitrophenol to Americans lured by the promise of a drug that would safely melt one’s fat away.

Cyril MacBryde, a physiologist from Washington University School of Medicine, reported ‘‘alarming functional changes’’ indicative of liver, heart, and muscle toxicity in his obese patients treated with small doses of dinitrophenol (MacBryde and Taussig, 1935).​

But some physicians continued to believe that the drug was a reasonable therapeutic option for obese patients recalcitrant to dietary intervention when used in the properdose and under the care of a knowledgeable physician. Even this position, however, became untenable when young women taking therapeutic doses of dinitrophenol under the supervision of physicians started going blind (Horner et al., 1935). If the estimate of one San Francisco ophthalmologist is accurate, during a two and a half year span, as many as 2500 Americans may have lost their sight due to what became known as ‘‘dinitrophenol cataracts’’ (Horner, 1936).​

 

[johnnyBALLZ]

WOW!!

Holy Christmas!! I've toyed with the idea of DNP before and I've done some minor research but this article is a game changer. Don't ever need to go down this road. As you said, the risks FAR outweigh the benefits. Thanks for the info..

 

[loveyourbody]

Dr.jim- we can try as much as we want there will all ways be people trying to say something is safe till they have to learn the way I did. Or maybe I was just the unlucky one and got every single worst side you can get. DNP IS NOT WORTH IT