DNP Guy
Subscriber
And...? Lol jk brother. Enjoy.
MESO-Rx
Anabolic Steroids
DNPGUY
- Thread starter DNP Guy
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Girls been on for a week. She's gonna run for 3 and I'll report back
Kpaxi
Member
I have. Low dose 200 mg upped to 400. I felt it at 200 and 400 was rough
DNP Guy
Subscriber
Oh ok. I had gotten a different impression. My apologies.
Kpaxi
Member
No your impression was right. I’m saying last time I took I did 200 into 400. With his stuff I’m at nearly 600 and barley feeling more than my last cycle at 200
DNP Guy
Subscriber
Ya 600mg is a lot. Ive noticed over the years that peoples tolerability towards DNP seems to be more or less the same unlike any other drug. Everyone seems to be able to handle 400mg for a week or two but 600mg for even a few days gets to be too much.
DNP Guy
Subscriber
So I was asked in email again about 50mg caps. I can not make 50mg caps unless I use a size 3 capsule which I'd have to individually weigh out with my micro scale for a few reasons. It would take me hours just to make 50caps.
The clinical trial was 3 75mg doses. Nobody got any life threatening effects of any kind and over a million doses were handed out. Ill have to find that for you guys.
The clinical trial was 3 75mg doses. Nobody got any life threatening effects of any kind and over a million doses were handed out. Ill have to find that for you guys.
DNP Guy
Subscriber
Just some reading material for those who are new to this drug/chemical.
Derek Lowe is a medicinal chemist working on preclinical drug discovery in the pharmaceutical industry, and has written a blog about his field called "In the Pipeline" since 2002.
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[https://blogs]
Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer.
[https://blogs]
By Derek Lowe
DIABETES AND OBESITY
Dinitrophenol: A Possible Comeback
By Derek Lowe 3 March, 2015
I’ve mentioned metabolic uncoupling as a possible diabetes therapy. The idea is that your mitochondria will plow though large amounts of lipids under these conditions, and there’s plenty of evidence that knocking down free fatty acids and tissue lipid stores would be of great benefit for Type II patients. The problem is that this therapy has a well-deserved reputation for having a low therapeutic index.
2,4-dinitrophenol is a pretty unlikely-looking drug, but it most certainly has metabolic effects. It was on the market for a while (many decades ago) as a weight-loss therapy, and no one can say that it won’t make you lose weight. The danger is that you lose it all the way down to your dry bone mass, though, because it doesn’t take much extra DNP to give you dangerous amounts of overheating and perhaps even a critical shortage of ATP, which frivolous organs like your heart and brain seem to have become dependent on. Various foolhardy types (extreme bodybuilders, etc.) have experimented with it since then, but it’s just too dangerous to recommend to anyone. Even short of death, there were other unpleasant side effects.
But there have been reports from time to time that the compound might still have legitimate uses, and a recent one from Gerry Shulman’s group at Yale is getting a lot of attention. Shulman is one of the world’s experts on diabetes and metabolism, and his lab has been working on DNP for some years now. The latest version is a time-release form of the drug, one that delivers up to 100-fold less Cmax than the standard human dose, if DNP can be said to have one.
This formulation does a dramatic job of reversing diabetes symptoms in rodent models, and fatty liver disease as well. Shulman is working on taking this toward human clinical trials, and the animal results make a good case. If this were any other drug showing these effects, people would be moving it forward as fast as possible – it’s just the history of DNP that’s going to make things more difficult. But we have the example of thalidomide – if that can find a therapeutic niche, anything can. The next key step will be rodent and dog tox studies, and if DNP can clear those, then I would see no reason not to take it on into Phase I and beyond. Who’d have thought?
Derek Lowe is a medicinal chemist working on preclinical drug discovery in the pharmaceutical industry, and has written a blog about his field called "In the Pipeline" since 2002.
Share on linkedin
[https://blogs]
Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer.
[https://blogs]
By Derek Lowe
DIABETES AND OBESITY
Dinitrophenol: A Possible Comeback
By Derek Lowe 3 March, 2015
I’ve mentioned metabolic uncoupling as a possible diabetes therapy. The idea is that your mitochondria will plow though large amounts of lipids under these conditions, and there’s plenty of evidence that knocking down free fatty acids and tissue lipid stores would be of great benefit for Type II patients. The problem is that this therapy has a well-deserved reputation for having a low therapeutic index.
2,4-dinitrophenol is a pretty unlikely-looking drug, but it most certainly has metabolic effects. It was on the market for a while (many decades ago) as a weight-loss therapy, and no one can say that it won’t make you lose weight. The danger is that you lose it all the way down to your dry bone mass, though, because it doesn’t take much extra DNP to give you dangerous amounts of overheating and perhaps even a critical shortage of ATP, which frivolous organs like your heart and brain seem to have become dependent on. Various foolhardy types (extreme bodybuilders, etc.) have experimented with it since then, but it’s just too dangerous to recommend to anyone. Even short of death, there were other unpleasant side effects.
But there have been reports from time to time that the compound might still have legitimate uses, and a recent one from Gerry Shulman’s group at Yale is getting a lot of attention. Shulman is one of the world’s experts on diabetes and metabolism, and his lab has been working on DNP for some years now. The latest version is a time-release form of the drug, one that delivers up to 100-fold less Cmax than the standard human dose, if DNP can be said to have one.
This formulation does a dramatic job of reversing diabetes symptoms in rodent models, and fatty liver disease as well. Shulman is working on taking this toward human clinical trials, and the animal results make a good case. If this were any other drug showing these effects, people would be moving it forward as fast as possible – it’s just the history of DNP that’s going to make things more difficult. But we have the example of thalidomide – if that can find a therapeutic niche, anything can. The next key step will be rodent and dog tox studies, and if DNP can clear those, then I would see no reason not to take it on into Phase I and beyond. Who’d have thought?
Holidaypay
Member
Guys we have a serious problem here I was scrolling through this thread an realized this guy didn't post any tit pics wtf guys ur slacking !!!SHOW SOME TITS!!! 
Guys we have a serious problem here I was scrolling through this thread an realized this guy didn't post any tit pics wtf guys ur slacking !!!SHOW SOME TITS!!!
WHAT!!!!!!!!!!! No tiddys? We need Tiddys and asshole pics stat. Ummm, not yours though....
Other DNP source on here, I paid for my order and then see a post that guys taking a week off to handle their product issue.....not legit or undedosed from the sounds of it......
To clarify, does ANY source on here have legit DNP and ready to do business or what
To clarify, does ANY source on here have legit DNP and ready to do business or what
Holidaypay
Member
Man ur lucky u said that I was gna bless u guys with a pic that would be in your nitmares forever lol
MisterSuperGod
New Member
Haha pretty pleased with the process. Started at 400mg and will continue there for a week.
LeoTC
Member
Tagging in the hopes we'll see more source on source clowning.
Why the fuck aren't our AAS sources doing the Pepsi / Coke price war thing damn it?
Why the fuck aren't our AAS sources doing the Pepsi / Coke price war thing damn it?
Hey guys. Want to try DNP for first time.
My tdee is 2200, bf % around 18-20. No AAS right now.
What is best option:
1. PSMF diet without cardio for 14 days (300mg/Ed)
2. Keto diet with cardio for 21 days (200mg/Ed)
My tdee is 2200, bf % around 18-20. No AAS right now.
What is best option:
1. PSMF diet without cardio for 14 days (300mg/Ed)
2. Keto diet with cardio for 21 days (200mg/Ed)
Sdryx
Member
LeoTC
Member
How's about just diet / cardio?
If you don't have the discipline to cut it down from there any loss is only going to be temporary anyway.
If you don't have the discipline to cut it down from there any loss is only going to be temporary anyway.
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