ED Issues Continue

This would be true if you didn't reduce the dose and you injected EOD. By reducing the dose and injecting more frequently the peaks and troughs level out considerably. The more you do this the closer you get to steady state.

The reason i am skeptical about eod injects is that even with a reduced dose levels peak quite high. So you would be getting a very high peak between 48-72 hours and then you inject again and tack onto that peak.

Yeah if you are doing 10-15mg eod it would be considerably lower.

But guys are doing 30-40mg eod and i think that amount of T still peaks quite high.

Cubbie has said that his libido came back when he stopped eod injects and it was best between 4-8 days. This means the 30mg eod he was doing was way too high and it's difficult to say what dose to drop down to.

There's a reason guys inject every week. 100mg/wk is standard for most. Some guys need less and it's easy to just drop down to say 70mg/wk for a month and see how it goes.

These types of protocols are tried and tested. The eod stuff is new and untested (clinical studies)
 
"So you would be getting a very high peak between 48-72 hours and then you inject again and tack onto that peak."

I don't have time to explain other than to say you're just wrong. This isn't magic and this concept is literally seen EVERYWHERE in medicine and pharmacology and it's not debatable. You can choose not to believe it for whatever reason but trust me....that's not how the pharmacokinetics of test cyp works.
 
I don't have time to explain other than to say you're just wrong. This isn't magic and this concept is literally seen EVERYWHERE in medicine and pharmacology and it's not debatable. You can choose not to believe it for whatever reason but trust me....that's not how the pharmacokinetics of test cyp works.

Ok i'll give it to you. But how do you explain his libido came back after a break from eod? You must agree that the dose is too high.
 
This is basic math.

No, it's pharmacokinetics. Like the rest have said here, you don't understand how the it works in regards to test cyp. Frequent injections result in a steady state level, infrequent injections do not. As Chem said, there's no stacking.
 
No, it's pharmacokinetics. Like the rest have said here, you don't understand how the it works in regards to test cyp. Frequent injections result in a steady state level, infrequent injections do not. As Chem said, there's no stacking.

I was just trying to help you figure out your libido. You said it came back with a break in eod injects. You said it was good from day 4-8. You are overshooting the sweet spot and then falling through it again.

I agree I dont understand the pharmacokinetics since I would think there would be a stacking effect.
 
I was just trying to help you figure out your libido. You said it came back with a break in eod injects. You said it was good from day 4-8. You are overshooting the sweet spot and then falling through it again.

I agree I dont understand the pharmacokinetics since I would think there would be a stacking effect.

It's really not hard to understand. Stacking would only happen indefinitely if 100% of the test you injected remained in your body. You know of course this doesn't happened because it's metabolized and excreted. It is the ratio of test going in and test going out that we're talking about.

When you take 200mg injection every 2 weeks you see a huge spike in test because the 200mg GREATLY exceeds metabolism/excretion. Over the course of the next 2 weeks no new test is added and you body works it's way through until your next big injection.

Now say you inject 30mg EOD. The rise in test is not nearly as great and while you may see some small rise in levels initially this small dose means over the course of the injection day plus the next day the amount of test going in and going out are equal. No spike and no dip.

Now your absolutely correct that if you start off with very low T and start injections there's some "stacking" effect in the beginning - this is why it takes weeks to reach a steady state. Steady state means you've seen all the stacking you're going to see and now 30mg EOD equals the average tT over those two days with 30mg going in on day 1 and 30mg coming out on day 2 just to be followed by 30 mg going in on day 3 and 30mg coming out on day 4........

Make sense now?
 
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It's really not hard to understand. Stacking would only happen indefinitely if 100% of the test you injected remained in your body. You know of course this doesn't happened because it's metabolized and excreted.

Now say you inject 30mg EOD. The rise in test is not nearly as great and while you may see some small rise in levels initially this small dose means over the course of the injection day plus the next day the amount of test going in and going out are equal. No spike and no dip.

Now your absolutely correct that if you start off with very low T and start injections there's some "stacking" effect in the beginning - this is why it takes weeks to reach a steady state. Steady state means you've seen all the stacking you're going to see and now 30mg EOD equals the average tT over those two days with 30mg going in on day 1 and 30mg coming out on day 2 just to be followed by 30 mg going in on day 3 and 30mg coming out on day 4........

Make sense now?

It would make more sense to me if I saw some numbers.

I do understand that on a longer timeline steady state means the "back end" injects fade out so I understand why there would be no stacking once one reaches steady state.

That said, how long does it take to reach steady state for eod injects? Because there would be stacking until one reaches it.
 
It would make more sense to me if I saw some numbers.

Visualize the following:

[1] A dose of T (x mg), injected once a week, has your tT at 500 when you are at 84 hours (that's 3.5 days, or the midpoint) after the injection. The issue is that your tT was a lot higher than 500 on Day 1, and a lot lower than 500 on Day 6. The difference between peak and trough is large.

[2] Now you inject half that amount (x/2), twice a week. The peak is smaller now, right? It has to be, you're injecting half as much T ! This has your tT at 500 when you are at 42 hours (that's 1.75 days, or the midpoint) after the injection. Your tT on Day 1 was high, but not as high as it was on Day 1 with a once a week injection. Your tT on Day 3 is low, but not as low as it was on Day 6 with a once a week injection. The difference between peak and trough is getting SMALLER.

[3] Now inject eod. The dose is (x/3.5). The peak is even smaller; it has to be. Now your tT is at 500 when you are at 21 hours after injection and, again, the peak is not as much above 500 as it was with the previous two protocols. Similarly, the trough isnt as much below 500 right before you inject. The difference between peak and trough is now even smaller and, as you reach steay state, there isnt room for it to change very much.

When you do this, you are adding T at such a gentle dose AND at at such a high frequency, that your tT is not changing much from a level of 500. If you overshoot, it wont be by very much. If you undershoot, it wont be by very much. The variability is SMALL. It has to be.

It certainly wont be anything like how you can undershoot/overshoot by injecting one time a goddamn week!
 
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Well the arimidex experiment isn't working. Even a miniscule dose (.125mg) sends my E2 WAY too low. I am good on it for about a day, then I lose wood, and I get the loss of sensitivity that is consistent with a very low E2. Also joint aches come on. After a few days I bounce back. Next things I want to try:
12 mg eod (then titrate up/down depending on libido and eq)
70 mg 2x per week with no AI
100 mg 1x per week
140 mg 1x per week (might as well try Tyler's theory)
compounded test cream
 
Well the arimidex experiment isn't working. Even a miniscule dose (.125mg) sends my E2 WAY too low. I am good on it for about a day, then I lose wood, and I get the loss of sensitivity that is consistent with a very low E2. Also joint aches come on. After a few days I bounce back. Next things I want to try:
12 mg eod (then titrate up/down depending on libido and eq)
70 mg 2x per week with no AI
100 mg 1x per week
140 mg 1x per week (might as well try Tyler's theory)
compounded test cream[/QUOTte]

Cubbie, since ive been studying receptor pharmokinetics Im becoming more and more convinced that the androgens are only one player in a complex process.
Serotonin, dopamine and probably norepi are at least equallly important to both libido and performance. Seratonin helps regulate dopamine. The 5ht2a subreceptor is clearly linked to performance and likely, libido. From my experience blocking it is a very good thing and has restored my morning wood and even eliminated PDE5I use much of the time.
I think you could well benefit from reading the paper BBC3 posted in my trazadone thread a few weeks ago.

Try this for the pharmaconetic issue \:
http://chemwiki.ucdavis.edu/Physical_Chemistry/Kinetics/Reaction_Rates/Half-lives_and_Pharmacokinetics
 
Well, after a ton of playing around over the course of a year, I've finally found something that works and has worked for the past several months. Good libido and no ED with the following:

56 mg of T every Friday morning.

250-500 iu hcg every Tuesday morning.

Haven't had to take any pde5's in almost 3 months.

Every time I lost libido, I would just stop everything until it came back. I would try something different - 80-200mg per week, in a variety of different dosages. Very hit or miss and I relied a lot on compounded cialis.

Finally I just started at a super low dose once per week (40mg) and titrated up by 4mg until I hit something I liked.
 
I like that a lot - any labs with that protocol?

EOD still works well for me with HCG.

With 20 mg T-cyp eod and 250 IUs HCG once a week (as a substitute for the T-shot) my tT was 505 and E2 was low 20s and now I'm gradually increasing the T-dose. Libido is more constant (even though at baseline it isnt an issue for me) with one HCG shot a week alternating with two shots a week. After getting labs, I may raise the once a week HCG shot to 500 IUs.

Good to hear you're doing well, CB.:)
 
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