He's only been told this about, like, 475,986,647 times.
I don't buy it. I feel best injecting every 5-7 days.
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He's only been told this about, like, 475,986,647 times.
This would be true if you didn't reduce the dose and you injected EOD. By reducing the dose and injecting more frequently the peaks and troughs level out considerably. The more you do this the closer you get to steady state.
I don't buy it.
This is like telling me you think the Earth is flat.
I don't have time to explain other than to say you're just wrong. This isn't magic and this concept is literally seen EVERYWHERE in medicine and pharmacology and it's not debatable. You can choose not to believe it for whatever reason but trust me....that's not how the pharmacokinetics of test cyp works.
My libido is best on a 5-7 injection protocol. Solid from day 4-7.
When compared to what?
You've never tried an eod protocol at anything near the right dose.
What is the "right dose"?
How long have you been on this board, Tyler?
You already know the answer to this question.
This is basic math.
No, it's pharmacokinetics. Like the rest have said here, you don't understand how the it works in regards to test cyp. Frequent injections result in a steady state level, infrequent injections do not. As Chem said, there's no stacking.
I was just trying to help you figure out your libido. You said it came back with a break in eod injects. You said it was good from day 4-8. You are overshooting the sweet spot and then falling through it again.
I agree I dont understand the pharmacokinetics since I would think there would be a stacking effect.
It's really not hard to understand. Stacking would only happen indefinitely if 100% of the test you injected remained in your body. You know of course this doesn't happened because it's metabolized and excreted.
Now say you inject 30mg EOD. The rise in test is not nearly as great and while you may see some small rise in levels initially this small dose means over the course of the injection day plus the next day the amount of test going in and going out are equal. No spike and no dip.
Now your absolutely correct that if you start off with very low T and start injections there's some "stacking" effect in the beginning - this is why it takes weeks to reach a steady state. Steady state means you've seen all the stacking you're going to see and now 30mg EOD equals the average tT over those two days with 30mg going in on day 1 and 30mg coming out on day 2 just to be followed by 30 mg going in on day 3 and 30mg coming out on day 4........
Make sense now?
It would make more sense to me if I saw some numbers.
Well the arimidex experiment isn't working. Even a miniscule dose (.125mg) sends my E2 WAY too low. I am good on it for about a day, then I lose wood, and I get the loss of sensitivity that is consistent with a very low E2. Also joint aches come on. After a few days I bounce back. Next things I want to try:
12 mg eod (then titrate up/down depending on libido and eq)
70 mg 2x per week with no AI
100 mg 1x per week
140 mg 1x per week (might as well try Tyler's theory)
compounded test cream[/QUOTte]
Cubbie, since ive been studying receptor pharmokinetics Im becoming more and more convinced that the androgens are only one player in a complex process.
Serotonin, dopamine and probably norepi are at least equallly important to both libido and performance. Seratonin helps regulate dopamine. The 5ht2a subreceptor is clearly linked to performance and likely, libido. From my experience blocking it is a very good thing and has restored my morning wood and even eliminated PDE5I use much of the time.
I think you could well benefit from reading the paper BBC3 posted in my trazadone thread a few weeks ago.
Try this for the pharmaconetic issue \:
http://chemwiki.ucdavis.edu/Physical_Chemistry/Kinetics/Reaction_Rates/Half-lives_and_Pharmacokinetics
.. The 5ht2a subreceptor is clearly linked to performance and likely, libido. From my experience blocking it is a very good thing and has restored my morning wood and even eliminated PDE5I use much of the time. ..
