Theoretically, Boldenone can only exert it's action when it's cleaved from the ester. I don't see how it can become active in esterified form. If you inject more frequently, you will get less high peaks but the net amount released over time will be roughly the same, or exactly the same if you use the same dose over a cycle with different pinning frequency. I expect the fluctuations in serum estrogen to be minimal anyway with EQ, but it will always be more stable when you pin more frequently. The question is if you would notice a difference. I think not. But it can't be ruled out.