MESO-Rx
Anabolic Steroids
Estradiol = Estrogen = e2???
- Thread starter DaVinci2
- Start date
The_Skeptic
New Member
DaVinci2 said:
The way I understand it, Estradiol is E2, which is one of many estrogens, but the one we need to worry about the most because it is the one that rises when T rises, and causes us all those problems.
marianco
Doctor of Medicine
Estradiol (E2) is the most potent naturally occurring form of estrogen.
Measuring Estradiol alone will give you an idea of the total estrogen activity because it gives you the total estradiol itself plus some of the activities of the rest of the estrogens.
To determine how much estrogen activity is only due to Estradiol alone, you have to do a fractionated estrogens test. This will break down the estrogens into Estradiol, Estrone, Estriol, and give you the total estrogen level.
For the purpose of hormone replacement therapy, a single measurement of Estradiol alone gives a good idea of the total estrogen activity and is useful for making clinical decisions. It also can be done very quickly as opposed to a fractionated estrogen test.
If there are complicating factors, if a patient is not responding as expected, it may then be useful sometimes to order a fractionated estrogens test, to help figure out what is going wrong. The Estradiol level obtained from a fractionated estrogens test will be different from the single Estradiol test. They can't be compared since they are different tests.
Measuring Estradiol alone will give you an idea of the total estrogen activity because it gives you the total estradiol itself plus some of the activities of the rest of the estrogens.
To determine how much estrogen activity is only due to Estradiol alone, you have to do a fractionated estrogens test. This will break down the estrogens into Estradiol, Estrone, Estriol, and give you the total estrogen level.
For the purpose of hormone replacement therapy, a single measurement of Estradiol alone gives a good idea of the total estrogen activity and is useful for making clinical decisions. It also can be done very quickly as opposed to a fractionated estrogen test.
If there are complicating factors, if a patient is not responding as expected, it may then be useful sometimes to order a fractionated estrogens test, to help figure out what is going wrong. The Estradiol level obtained from a fractionated estrogens test will be different from the single Estradiol test. They can't be compared since they are different tests.
snipe
New Member
Interestingly until using I3C ( or currently DIM) my Total E's were high (180), yet my Estradiol, Estrone and Estriol were all mid to low normal.
snipe said:
How has the DIM been working for you? Prior to any TRT my E2 was 17, Estriol 25, yet my Total Es was 143 (ref <130)...not that high but higher than the range given. Told that Total Es isn't that big a deal and Estradiol is the key player, but I'm curious if my Total Es is keeping my T levels down in the 390s.
Just curious. Thanks.
I started using DIM/Indoplex and TMG about 4 weeks ago. I have not got my total E's or E2 tested and wont for a few more weeks but from my general observations my libido has increased a little and i have morning wood everyday now.
I have been taking 125mg of DIM/Indoplex and 500 mg TMG.
I have been taking 125mg of DIM/Indoplex and 500 mg TMG.
snipe
New Member
rockin813 said:
My Total E's were 125 this past Feb. (Ref. <130) I'm still taking the same 120mgs DIM and am due to have some labs done fairly soon. I'll post the #'s.
snipe
New Member
rockin813 said:
Actually I3C had my #"s down to 100. After being on DIM for a couple of months they were up to 125. My Doc felt I3C created 4-OH estrogen compounds while DIM did not. Therefore the switch.
Overall I felt no different regardless of estrogen levels. My reason for using anti-e's has always been based on lab #'s.
Raising my testosterone from 259 to 1100 (currently mid 800's) on the other hand made a big difference.
snipe said:
thanks. so getting my total Es down to below range won't do anything for me as well? probably the case.
im gonna be tyring HCG alone to get my 390 T levels up to 800 levels or so 5 weeks from now. Previous TRT got me into the high 1200s yielding zero benefits...as my E2 grew to 76!
thanks again!
jack
snipe
New Member
rockin813 said:
Hard to say......everyone reacts differently. What may have bearing for how you feel may not for me.
I've also been on Arimidex @ 0.25mg, 3 days/week. Perhaps TRT would have had a more positive effect for you had E2 been kept in control. (Remember to always ask for the Estradiol, Ultra-Sensitive test.)
Hi Snipe,
Were you using other forms of anti estrogens?
So I3C alone was able to lower your total estrogens?
Also how long were on I3C for before you noticed the drop?
Did you notice any improvements from the drop in total estrogens?
My total estrogens are high, and I am looking for something less potent then arimidex, if possible.
Thanks!
Were you using other forms of anti estrogens?
So I3C alone was able to lower your total estrogens?
Also how long were on I3C for before you noticed the drop?
Did you notice any improvements from the drop in total estrogens?
My total estrogens are high, and I am looking for something less potent then arimidex, if possible.
Thanks!
snipe said:
snipe
New Member
TylerR said:
I've been using the low dose of Arimidex throughout but, Adex alone never seemed to have much effect on my total E's.
I3C alone (on for about 2 months) was able to lower my total E's but, when I tried discontinuing the Arimidex my estrone rose.
No difference with the lower total E's.
I3C alone (on for about 2 months) was able to lower my total E's but, when I tried discontinuing the Arimidex my estrone rose.
No difference with the lower total E's.[/QUOTE]
While on TRT my T levels did get to 1288 a day before the 'trough' period...this was 8 weeks into testing. Also got my E2 tests at the same time and it came back at 76....was prescribed Arimidex to bring it down and lowered my T shot from 100mg to 80mg. A week later I met with an Endo and discussed family planning...since then discontinued the TRT and will be doing HCG in 4 weeks from now (I'm secondary hypoG..with an already great sperm count that i don't want to lose from TRT). Anyway, I continued with the Arimdex but will now stop as my E2 should be down from the 76 level a month ago (as I'm not taking TRT). However, my Total Es were 175 while on TRT (143 prior to TRT) with range being <130. Maybe I need to try I3C to see if it lowers my Total Es and brings my 390 T levels up.
What exactly is I3C? Prescription or OTC?
Thanks
No difference with the lower total E's.[/QUOTE]
While on TRT my T levels did get to 1288 a day before the 'trough' period...this was 8 weeks into testing. Also got my E2 tests at the same time and it came back at 76....was prescribed Arimidex to bring it down and lowered my T shot from 100mg to 80mg. A week later I met with an Endo and discussed family planning...since then discontinued the TRT and will be doing HCG in 4 weeks from now (I'm secondary hypoG..with an already great sperm count that i don't want to lose from TRT). Anyway, I continued with the Arimdex but will now stop as my E2 should be down from the 76 level a month ago (as I'm not taking TRT). However, my Total Es were 175 while on TRT (143 prior to TRT) with range being <130. Maybe I need to try I3C to see if it lowers my Total Es and brings my 390 T levels up.
What exactly is I3C? Prescription or OTC?
Thanks
snipe
New Member
I3C (Indole 3 Carbinol) and DIM (Diindolylmethane) are compounds found in cruciferous vegatables.
Both are OTC.
Both are OTC.
rockin813 said:
While on TRT my T levels did get to 1288 a day before the 'trough' period...this was 8 weeks into testing. Also got my E2 tests at the same time and it came back at 76....was prescribed Arimidex to bring it down and lowered my T shot from 100mg to 80mg. A week later I met with an Endo and discussed family planning...since then discontinued the TRT and will be doing HCG in 4 weeks from now (I'm secondary hypoG..with an already great sperm count that i don't want to lose from TRT). Anyway, I continued with the Arimdex but will now stop as my E2 should be down from the 76 level a month ago (as I'm not taking TRT). However, my Total Es were 175 while on TRT (143 prior to TRT) with range being <130. Maybe I need to try I3C to see if it lowers my Total Es and brings my 390 T levels up.
What exactly is I3C? Prescription or OTC?
Thanks[/QUOTE]
Rockin,
If your T levels went that high, it might be normal to also have high Total Es. What are your current E levels at now that you've stopped TRT.
