Estradiol still high despite being on Anastrozole 0.25mg twice a Testosterone dose is 160mg a week split twice a week. Do I lower dose? Increase AI?

[iorigins91]

Am I taking Anastrazole wrong? I take the dose on day of injection, but I found a couple studies that say 12-36 hours after. Labs were drawn Monday morning before injection day.
I am taking testosterone c splint twice a week of 160mg (80mg) Monday morning and Thursday evening.

Before TRT estradiol was 20.

Without AI it was 70.

And with AI 0.25mg twice a week it’s 58.

Should I drop my dose of testosterone? Take Ai a day after injection? Increase AI to 3x a week?

Symptoms: no morning wood, fatigue, lack of drive and motivation, feel weaker at gym, holding stomach fat.

I’ll have to say, first few weeks on TRT I felt amazing, and then coming to 6 months now of trying to dial in I feel like shit.

I’ve done TRT before and it was the same thing last time it was with HCG , felt amazing like first 3 weeks and then shit.

The only positive note I have is strength and muscle gains.

Best way to control this estradiol? Should I take AI day after?? Or add a 3rd dose of 0.25mg on Saturday.









More labs:




Also, I just donated blood again because my doctor wasn’t too happy with my CBC. So I probably tanked my already low ferritin.

So yeah I’m 6 months in, last time I did TRT I was 4 months in gave up because I couldn’t get dialed in. This time I’m 6 months in and I am trying to get dialed in chasing what I felt the first 3 weeks on it. It was life changing for those first 3 to 4 weeks.

 

[brutalbuilt]

twice a week is not enough you gotta take it daily or eod to keep levels steady

 

[bananafeet]

You need to lower your dose bro. Donating blood will lower your haematocrit but like you have said it will also lower your iron levels.

E2 isn't causing stomach fat at those levels your diet is. Have you been tested for sleep apnea?

I'd drop your dose to 75mg per week until you lower your HCT. At that dose you really shouldn't need an AI. Once per week injection should also be fine at that amount.

 

[Nidus]

Ferritin is really low but HT and HB is quite high, should defo work on that too.
What are your stats?

 

[Eddie.]

If you're after a true TRT lower your dose, you respond very well on test and this is a high number. Go for 60mg twice a week or 40mg 3 times a week (better).

Estradiol is very high indeed for that test dose and AI you're taking. I'd say increase the pinning frequency, lower the dose to 120mg and retest in 3-4 weeks. If e2 is still high, add another dose of 0,25 anastrozole.

There's a chance you respond poorly to anastrozole though, you could try switching to aromasin and see how it goes. Overall is a better AI for long term use, also it has a longer halflife and that makes it more suitable for 2 servings per week compared to anastrozole. By the way, are you sure your AI is legit? Is it from pharmacy or UGL?

Also fix your ferritin asap and do a complete iron panel.

 

[Jin23]

Am I taking Anastrazole wrong? I take the dose on day of injection, but I found a couple studies that say 12-36 hours after. Labs were drawn Monday morning before injection day.
I am taking testosterone c splint twice a week of 160mg (80mg) Monday morning and Thursday evening.

Before TRT estradiol was 20.

Without AI it was 70.

And with AI 0.25mg twice a week it’s 58.

Should I drop my dose of testosterone? Take Ai a day after injection? Increase AI to 3x a week?

Symptoms: no morning wood, fatigue, lack of drive and motivation, feel weaker at gym, holding stomach fat.

I’ll have to say, first few weeks on TRT I felt amazing, and then coming to 6 months now of trying to dial in I feel like shit.

I’ve done TRT before and it was the same thing last time it was with HCG , felt amazing like first 3 weeks and then shit.

The only positive note I have is strength and muscle gains.

Best way to control this estradiol? Should I take AI day after?? Or add a 3rd dose of 0.25mg on Saturday.






View attachment 334234


More labs:

View attachment 334236View attachment 334235


Also, I just donated blood again because my doctor wasn’t too happy with my CBC. So I probably tanked my already low ferritin.

So yeah I’m 6 months in, last time I did TRT I was 4 months in gave up because I couldn’t get dialed in. This time I’m 6 months in and I am trying to get dialed in chasing what I felt the first 3 weeks on it. It was life changing for those first 3 to 4 weeks.

This is not trt, which should fall in around 500 - 700 ng/dl. You are for all intends and purposes on a light perma cycle, ie. trt+ and that's the root of your issues.

Drop your dose by basically a half, stay there for a prolonged period of time, and you'll be fine, no ai needed, no iron and hematocrit issues, no mental problems. A prolonged high dose as this will also give you mental issues, depression, anxiety ...

Whoever is convincing you this is trt (probably a money grab trt clinic) is not doing you any favours.

 

[Elektrobot]

Before TRT estradiol was 20.

Without AI it was 70.

And with AI 0.25mg twice a week it’s 58.

What is your height / weight / body composition?

 

[HUGE McBIGLARGE]

If I was you, I’d do this:
-lower the T dose to get your free T and total T in range
-experiment with an AI. If you feel no worse with lower e2, try to get your e2 in range. If you feel worse with lower e2, keep your e2 where you feel best
-get the RBC markers in range
-follow this to get normal ferritin Fixing High Hemoglobin or Hematocrit and Low Ferritin While on TRT

When your RBC and ferritin markers look good, then try a higher T dose if you want.

 

[newguy2]

If you get your total T in range the high e2 plus blood issues will likely go away. You seem like a high responder like me. I had to drop from 200mg a week to 120mg. You would likely drop to 100mg a week and be in the upper range.

 

[iorigins91]

Also I cannot get Ferritin up( and yes I tried the volck protocol with one of the brands of irons he recommended) I did it for 5 days. I’m surprised my stool didn’t turn dark or have cramps. Maybe I did it incorrectly? Also I heard if estradiol is too high the protocol doesn’t work?

Do you think it could be my low Ferritin? I went to a hematologist 2 days ago and she brushed me off saying since my Iron and iron saturations is normal she states there is no way Ferritin can cause any symptoms since it’s just a “pantry” if my body needed more iron. She said she won’t do an infusion since iron is normal and my CBC is not low. She said she wants to repeated phlebotomies until I feel better.

Also I dropped my dose from 160mg to 120mg since my initial thread of posting this, not sure when I’m supposed to feel better. Also, if the dose is the case that it’s too high how the hell do so many people cruise on 200mg or higher and feel amazing?






I’m not sure what my body fat is, I’m 6’0”. This is my body:

My EPO levels not sure what they should typically be on TRT:


Again, I felt AMAZING on first 3 weeks on TRT, life changing. But then crashed hard.

 

[HUGE McBIGLARGE]

Do you think it could be my low Ferritin?

If you’ve been taking iron in an attempt to raise ferritin, and you are 100% certain your ferritin isn’t rising at all, stop taking the iron. It could be that the iron you’re taking is raising the RBC markers.

No point in taking the iron if your ferritin isn’t going up.

I’m not sure what my body fat is, I’m 6’0”. This is my body:

Around 20% I’d say.

 

[Tbaz192]

Fixing High Hemoglobin or Hematocrit and Low Ferritin While on TRT

curious to wonder if this would help on cycle or not. With normal RBC/CBC.
Dumb or not haha idk

My body is notorious for depleting my ferritin any time my test dose is higher than 200mg a week

 

[HUGE McBIGLARGE]

curious to wonder if this would help on cycle or not. With normal RBC/CBC.
Dumb or not haha idk

My body is notorious for depleting my ferritin any time my test dose is higher than 200mg a week

Worked for me with normal RBC markers.

 

[Ghoul]

If you get your total T in range the high e2 plus blood issues will likely go away. You seem like a high responder like me. I had to drop from 200mg a week to 120mg. You would likely drop to 100mg a week and be in the upper range.

What impact did it have on your mood and motivation?

 

[Tbaz192]

Worked for me with normal RBC markers.

I’ll have to give it a shot.
Waiting to pull my ferritin. The 4th delayed that.
But slight headaches and I’m pale as fuck & very fatigued

 

[newguy2]

What impact did it have on your mood and motivation?

The high e2? I honestly didn't notice any mood issues that I was aware of. But I might not be super aware of that sort of thing unless it's real bad

I had spicy nips for a while that I was king of ignoring. And as my serum levels peaked out I went from enhanced action in the bedroom to starting to have some ED issues.

Backing off and knocking it down with some adex did the trick.

 

[Ghoul]

The high e2? I honestly didn't notice any mood issues that I was aware of. But I might not be super aware of that sort of thing unless it's real bad

I had spicy nips for a while that I was king of ignoring. And as my serum levels peaked out I went from enhanced action in the bedroom to starting to have some ED issues.

Backing off and knocking it down with some adex did the trick.

The drop from 200 to 120.

 

[newguy2]

The drop from 200 to 120.

Didn't notice much. But I started a cycle not long after so not sure how much levels had dropped.