If your lady is menopausal you can also look into adding estradiol and possibly progesterone into the hormone mix.
If you have a uterus you need to run progesterone with your estradiol to prevent thickening of the uterine lining.
You'll need to dial in doses with blood work, but a typical starting point is 2mg of estradiol daily and 200mg of progesterone nightly.
Vitamin D is also typically supplemented, 5 to 10k iu daily
these hormones will help with sleep, mood and hot flashes.
My girl does this all through a hormone Dr, we spend about $2500 a year. It's $600 to get pellets every 4 months, plus blood work and the progesterone, pregnenolone, estradiol, armour thyroid and iodine.