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@Ghoul it’s possible you use a higher quality PES membrane with a more thorough treatment to reduce protein binding.

All PES is not made equal. In fact before it is treated, it is hydrophobic and therefore highly protein binding and unsuitable.Coincidentally I just happened to already be using the same filter used for that specific test. Pall Pharmassure, the filter of choice in compounding pharmacies.
It's PES material, specifically the high performance branded type called "Supor", which is in a few filter brands. Pall and Braun both use it.
However, it's not significantly different from any other good brand of filter. Besides. .22um pores are over 50x times wider than the size of an rHGH monomer. So you're not exactly shoving it through an opening that's too small.
Finally, all peptide drugs, including rHGH, are sterilized by .2um filtration as a final step in manufacturing. Often more than once, during the entire process. So that should allay any concerns about filter damage.
View attachment 351141
I use the cheap ass sterile aliexpress ones and have zero issues, just as a datapoint.All PES is not made equal. In fact before it is treated, it is hydrophobic and therefore highly protein binding and unsuitable.
Also, it’s more about hydrophobic interactions mixed with shear rather than the literal sizes of the pores.
The surfactant is able to ameliorate this issue by occupying hydrophobic sites.
I wasn’t saying that filtering was an issue btw, just pointing out a reason why you might be having success filtering your hgh while I wasn’t with my cobetter pes membranes.
Likely the hydrophilic treatment is of a superior quality in those Supor membranes.
All PES is not made equal. In fact before it is treated, it is hydrophobic and therefore highly protein binding and unsuitable.
Also, it’s more about hydrophobic interactions mixed with shear rather than the literal sizes of the pores.
The surfactant is able to ameliorate this issue by occupying hydrophobic sites.
I wasn’t saying that filtering was an issue btw, just pointing out a reason why you might be having success filtering your hgh while I wasn’t with my cobetter pes membranes.
Likely the hydrophilic treatment is of a superior quality in those Supor membranes.
I’m just reasoning backwards due to assuming you aren’t having issues and I am, for example you aren’t noticing it clogs your 13mm filters easily?That's why I specified "good" brands. I would've expected Cobetter to fall into that group though. They're not a no-name filter company, but a fairly big player that's been around for 20 years.
They even specify they use their own proprietary technology for a "premium" PES filter member.
Polyethersulfone (PES) Membrane
cobetter.com
What ps20 are you using?
I did look into this for awhile but could not find a USP grade or better source without breaking the bank. Was actually hoping to use it for tesa, not hgh tho.
HPBCD and cyclodextrin too, could not find a reliable source lol
Worth noting this is not refined or tested for toxins and not intended for biological applications. I did contact them to query.
It has a coa for heavy metals and It’s below the limits. What tells you its not refined?
Seems like it would need to be refined to meet the specifications here:
Did you ever find a spot for bulk cyclodextrin? Or were you joking? Curious thanksWhat ps20 are you using?
I did look into this for awhile but could not find a USP grade or better source without breaking the bank. Was actually hoping to use it for tesa, not hgh tho.
HPBCD and cyclodextrin too, could not find a reliable source lol
Did you ever find a spot for bulk cyclodextrin? Or were you joking? Curious thanks
Endotoxin - I don’t mind it not being tested. A refined non-biological product will have negligible levels. The peptides and hgh itself don’t have endotoxin testing either.This is general/industrial grade? Endotoxin, microbial, elemental values? The listed values don't conform to pharm grade at all. The company specifically told me it was not a pharm grade product when they sent the above information.
What we using to filter? Filter needles? Bc i lowkey had the same questionHow much does filtering hgh really do in terms of harm reduction. Any knowledgeable members?
Serostim should be no higher than 500$ a box$5 per IU if you can acquire it. Not a given.
Great price. Congrats.Serostim should be no higher than 500$ a box
