From TRT to 350mg blast, 5.5 weeks in and crazy anxiety and panic randomly. Can't sleep. High e2? Am ready to jump off of a building

[OnTRT]

Now that I'm older high estrogen levels will give me extreme anxiety. Sounds like high Estrogen levels. I did something similar, decided to bump my weekly testosterone from 250mg to 500mg for a little blast. I was a wreck for months, panic attacks, legs always felt stiff, always on edge. My mind was always racing, basically in a state of panic. Once you have one panic attack, your very sensitive waiting for the next one. The big one for me was, if I felt I couldn't breathe right through my nose I started to freak out. One day I thought this could be high estrogen and just front loaded like 2mg of Armidex one night, I started feeling better a few days later, I did crash my estrogen but the anxiety was very much improved. I then realized high estrogen fucks with me personally. I dropped back to 250mg per week, and have felt much better. I got blood tested, and at 250 my estrogen was still like 65. I switched to .50mg of armidex twice a week and feel even better. I think the reason it took me so long to find the culprit is that most men don't have such a reaction to high estrogen levels. I apologize if my wording doesn't make perfect sense. Just comming off covid and I have extreme brain fog.

The can't breathe out of the nose thing is what causes the first panic attack. Was already having the swallowing problem, was getting a back massage on couch by GF, couldn't breathe out of nose and FREAKED THE FUCK OUT. Never had that before. Have been having daily panic or anxiety attacks on some mild level since then, and that was over a month ago.

Stopped taking daily cialis to control any potential reflux, and keep my nose open.

My e2 was never really high though at 46.7 on the sensitive test. A standard test would have probably shown it anywhere from 40-60 since it's so unreliable (I've done both tests on same day twice before). Now my e2 is lowest it's ever been on test and I feel bad.

 

[Rido]

Maybe try a different oil... Idk, or blasting isn't for you

 

[Alistair7]

OP, you could try using a different AI than Arimidex. I prefer exemestane as it has a higher margin of error than arimidex or Letro. Meaning, it’s harder to take too much and crash E2 on it. You can definitely do so but it’s much harder to screw it up than something like arimidex.

Too high of estrogen causes me to overreact to situations. As soon as I get it back down to a normal level, I’m fine.

 

[Live_Evil]

OP, you need to go to a Dr, but I have some useful insight for you.

I've struggled with severe acid reflux through out various periods of my life, and one thing that can happen in the night, is the acid coming up into the back of the throat and severely inflaming the tissue. At this point, the back of the throat closes off, and you wake up in a panic, unable to breath.

I've had it happen to such an extent and so often, I finally learned to shove my hand down my throat and spread my throat open, in order to breath and fucking stay alive. Luckily, it works like a charm. But I've seriously woken up thinking I would die, and seemingly only saved my own life my opening my throat. My ex would even breath for me until my throat finally opened back up, until I figured out to open my throat with my hand.

High E2 can cause a BP increase, and in many, the heart rate increases. That, compounded by a lack of sleep and the dramatic strain on the heart from oxygen depravation... not a good thing at all. Add panic on top of all that from not being able to breath, and you're in a really bad place.

All of the borderline psychosis you're experiencing is almost certainly nothing more than sleep deprivation coupled with overly dramatic emotional responses from high e2.

BTW, estrogen is directly linked with acid reflux. I can get up to 700mg weekly (possibly even higher) without needing an AI, but the acid reflux gets unbearable. I'm talking about acid so severe, double the recommended dosage of omeprazole still wouldn't touch it.

Take an AI, at a reasonable dose, and eat a handful of good antacids before bed like Pepcid, not shitty tums that won't even touch serious acid reflux. I would have had to take like 20-30 tums to stave off the acid for like 4 hours when it was hitting me hard, which always happened at night.

Also, avoid refined sugar.

EDIT: After reading your latest response, it seems your E2 is probably fine, but it's definitely possible you're having acid reflux at night or just sleep apnea. Either way, you need to get your sleep dialed in, so you can be sane while you're awake. Try some omeprazole + pepcid, and try to focus on figuring out your sleep situation.

Sleep apnea is worse the thicker your neck is, which is a problem many bodybuilders suffer from.

Sleep deprivation will make you insane quite rapidly. It's the entire reason meth heads turn into meth heads.

 

[OnTRT]

OP, you could try using a different AI than Arimidex. I prefer exemestane as it has a higher margin of error than arimidex or Letro. Meaning, it’s harder to take too much and crash E2 on it. You can definitely do so but it’s much harder to screw it up than something like arimidex.

Too high of estrogen causes me to overreact to situations. As soon as I get it back down to a normal level, I’m fine.

The crazy part to me is it was never super high. Now it's 23.9 and I feel like shit but not with the chest crushing anxiety. I still wonder if it was the high amounts of minoxidil, but that wouldn't explain the arimidex working. I like the idea of higher margin of error

 

[OnTRT]

OP, you need to go to a Dr, but I have some useful insight for you.

I've struggled with severe acid reflux through out various periods of my life, and one thing that can happen in the night, is the acid coming up into the back of the throat and severely inflaming the tissue. At this point, the back of the throat closes off, and you wake up in a panic, unable to breath.

I've had it happen to such an extent and so often, I finally learned to shove my hand down my throat and spread my throat open, in order to breath and fucking stay alive. Luckily, it works like a charm. But I've seriously woken up thinking I would die, and seemingly only saved my own life my opening my throat. My ex would even breath for me until my throat finally opened back up, until I figured out to open my throat with my hand.

High E2 can cause a BP increase, and in many, the heart rate increases. That, compounded by a lack of sleep and the dramatic strain on the heart from oxygen depravation... not a good thing at all. Add panic on top of all that from not being able to breath, and you're in a really bad place.

All of the borderline psychosis you're experiencing is almost certainly nothing more than sleep deprivation coupled with overly dramatic emotional responses from high e2.

BTW, estrogen is directly linked with acid reflux. I can get up to 700mg weekly (possibly even higher) without needing an AI, but the acid reflux gets unbearable. I'm talking about acid so severe, double the recommended dosage of omeprazole still wouldn't touch it.

Take an AI, at a reasonable dose, and eat a handful of good antacids before bed like Pepcid, not shitty tums that won't even touch serious acid reflux. I would have had to take like 20-30 tums to stave off the acid for like 4 hours when it was hitting me hard, which always happened at night.

Also, avoid refined sugar.

EDIT: After reading your latest response, it seems your E2 is probably fine, but it's definitely possible you're having acid reflux at night or just sleep apnea. Either way, you need to get your sleep dialed in, so you can be sane while you're awake. Try some omeprazole + pepcid, and try to focus on figuring out your sleep situation.

Sleep apnea is worse the thicker your neck is, which is a problem many bodybuilders suffer from.

Sleep deprivation will make you insane quite rapidly. It's the entire reason meth heads turn into meth heads.

I've never had what I would consider severe reflux. Bad bouts of it sure, but my tums were straight up expired, that's how little I need stuff. However August 5th I had eaten stuff I wouldn't normally eat, woke up earlier than normal, had 100mg of caffeine, went to gym way later than normal, did legs after drinking yellow Gatorade and my throat was torched. Everything was closed and I was texting my cousin like a crackhead asking if they had tums. Ended up buying some at gas station. Slept bad.

Next day panic attack mid massage, started waking up swallowing but no heart burn, all day throat tightness, next day another panic attack. Dropped dose days later back to TRT, then adex, then a week of no injecting, then back to normal TRT dose. During all of this I was getting 1 hour of sleep and waking up screaming because I couldn't stay asleep with this swallowing bullshit.

I fucked up along th way and ate a delta 8 gummy and woke up vomiting for hours until it was pure acid and torched my throat.

It's not big neck, I am TINY but am doing another sleep study soon. Did lab study last year and stumped the lab and two neurologists who were board certified in sleep but no apnea. Doing home study this time.

Had barium swallow a few days ago, showed mild reflux to distal third of esophagus, but eBay was after being on my stomach and then on my back and then coughing. They found small sliding hiatal hernia.


Now when I eat most of time I get INSTANT mucus feeling or cold feeling in throat. At least I'm 90% back to my crappy sleep I had before all of this, it's just hard to get out of a sleep deficit when you sleep worse than virtually anybody you ever meet and that's on your best day. I don't have any reserve for shit to get worse, so I have been losing my mind for over a month. Anxiety, anger, rage, panic, no feeling of normalcy over and over.

E2 was down to 23.9 on sensitive test a couple of weeks ago. Lowest it's ever been on test. On TRT dose. No AI in over a month. It was 32.8 back in June. Same total and free t levels. I'm baffled. Too am t variables.

 

[Juicedhead]

update?

 

[OnTRT]

bro im sorry you are experiencing this but its not gear related. see a doctor or a phyciatrist you are develping anxiety it sounds like to me but its not from test your levels are in normal range so youre just getting anxisty like anyone else would. see a doc

Wasn't regular anxiety. I can overpower being shot, I can overpower some random mental stuff, this was something that could not be turned off. I would guess very few people
Would even understand what it felt like. I was on SSRI through entire teens and part of adulthood, this was something entirely different. Tried a benzo and it didn't even touch it, nor could it knock me out. I've come off of Paxil after decades years ago, which causes INSANE mania, suicide thoughts non stop, complete brain fog and it was nothing compared to this. This was not standard anxiety or panic etc, this was something else completely.

It went away after getting off of the sun Pharma but took awhile. I know part of the reason now was the severe lack of sleep, less than one hour a day for 8 or 9 days? That was from the hiatal hernia and damaged LES, letting acid come up as a gas, so I had no idea because it wasn't standard heart burn that you could notice. So every time I laid down, I would start swallowing like crazy, the acid was torching my sinuses and Eustachian tubes and making mucus start flowing. Took a second ENT to catch this.

Sun Pharma has given other people weird anxiety, and I'm pretty e2 sensitive it seems, throw in no sleep for well over a week and it took awhile to get back to normal.

Still scared to ever try a blast again

 

[Juicedhead]

so youre good now? sonuds like extreme acid reflux was fucking with you tthroat

 

[Mrhairyman]

Regardless of dose, all AI make me feel terrible emotionally and mentally. I lowered my test-c (100 x2/week) and take 50 mg zinc daily.
I get better physical results at a higher test dose, but it is not worth my sanity.