Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Ghoul]

If his friend had an intestinal injury, that might be something a brave person would do. One of the outstanding questions for healthy people is whether decreasing the rate of apoptosis in the gut is beneficial. The process is so tightly controlled in healthy tissue that slowing it can lead to tumors.

One very interesting and noteworthy piece is that a person can be carrying extra fat while simultaneously being malnourished. This is frighteningly common among long-term obese people who report strict dieting but can't lose weight. It's one of the things that GLP-1 RAs seem to fix, which is almost miraculous... whatever metabolic derangement that obesity followed by severe nutrient restriction causes seems to be undoable with these drugs.

I did say Magellan

It's worth noting all of us GLP-1 users are using a substance that inhibits apoptosis in the brain....

https://www.sciencedirect.com/science/article/abs/pii/S0083672921000820#:~:text=However%2C%20GLP%2D1%20is%20also,behavior%2C%20and%20reduces%20food%20intake.

Once again a great set of observations. In earlier discussions regarding GLPs "miraculous" came to mind so often, in reference to the list of positive effects growing at an impossibly fast pace, I had to constantly reign in my enthusiasm to not sound like a religious zealot.

EDIT: Looks like we're onto second generation GLP-2's already. Once a week dosing. Long term doesn't show any increased risk of cancer, but, it has the potential to speed the growth of existing intestinal cancer, not unlike the risk with growth hormone, Interestingly, they use a lot of healthy subjects in the trials. Perhaps the short bowel folks are too medically fragile for the initial research. It's a rarity to see ethics panels allow healthy subjects to be used like this unless they're reasonably convinced of the safety of a drug.

Glepaglutide:

Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial - PubMed

Glepaglutide treatment in patients with SBS with intestinal failure resulted in clinically relevant reductions in PS requirements and was well tolerated. (ClinicalTrials.gov, Number: NCT03690206; ClinicalTrialsRegister.eu, Number: 2017-004394-14.).

pubmed.ncbi.nlm.nih.gov

 

[ve79]

I been takin trizapatide for 3 months at 5mg and lost 30lb thats no bs but my diet is on point with training . Source Axle

 

[Sampei]

The bloodwork my group has shows some people becoming depleted in B12, iron, and calcium (and D as a consequence) in that order. Usually a multi-vitamin fixes it, but I imagine he has tried that. Protein absorption is harder to measure, but at 300g, it's not really conceivable to take in any more.

The short version is that serum albumin is not a reliable indicator of protein intake. It is one strong influence, but it's not the only one, and those others are quite strong. Kidney function is one, and inflammation is another. For people who lift, we induce inflammation on purpose, so albumin is less reliable than it may be for other people. And depending on what drugs someone is taking, kidney health can change kinda fast -- even taking NSAIDs regularly will mess with your kidneys enough to throw off albumin.

The reliable measure of protein intake is going to be 24 urine capture with urea analysis. This is a pain in the ass and requires someone to stop physical activity for a while. The calculation requires equilibrium (anabolism = catabolism), so someone should be on an isocaloric diet and not exercising for a couple days beforehand. It's just a real mess.

It is highly unlikely for your friend to be lacking protein unless there's a secondary condition. If he came in and his urine showed negative nitrogen balance on that diet, I would immediately get him screened for cystic fibrosis, Chron's, and pancreatitis -- something actually obstructs or damages the small intestine. CF, at least in the US, is the most common reason for malabsorption and might be indicated by some really thick mucous coming out with his feces. But this is something an adult would almost certainly know beforehand because of the other complications of cystic fibrosis.

This is unfortunately someplace where going by feel and performance is what matters. Wish there was an easier answer.

This is amazing infos, I'll report back to him and he will probably do an urine test or some other test to try in nailing it down. Would a full abdomen echo help with some possible diagnosis?

 

[Volute]

Can the use of GLP-1 hinder absorptions of vitamins like iron? And protein? Decreasing level of albumin, same as if you were malnutritioned because you aren't absorbing and processing proteins properly?

Friend of mine is finding himself with low iron and low albumin level. Eating 300gr of proteine a day : /

I was getting symptoms of low iron (tiredness, paleness, crumbling fingernails) after long-term (about a year) glp-1 use. Didn't get a blood test but taking 45mg slow-release iron pills every other day caused pretty much immediate symptom relief.

 

[Nested]

For someone experienced with both compounds and only comparing their appetite-suppressing effects, if they're taking 7 mg of Tirz and want to switch to Reta, what dosage of Reta would be equivalent? I understand that the dosage needs to be increased gradually. I just need a rough estimate.

 

[The Answ3r]

I ordered Lyle M’s new book about GLP-1, and it should arrive next week. I’m interested to see his perspective on the topic and how it compares to what I’ve read so far. It’ll be good to get another viewpoint on the subject. I’ll share a summary once I’ve finished reading it.

 

[Nested]

…

 

[BabaJagga]

guys how to you even eat on this stuff?

started tirz last week, 2,5mg for the first time.
after 2 days my desire for any food is gone. i have to force protein shakes in just to get to protein goals. i cant imagine 5/7,5/10+ mg weekly.

 

[Ghoul]

guys how to you even eat on this stuff?

started tirz last week, 2,5mg for the first time.
after 2 days my desire for any food is gone. i have to force protein shakes in just to get to protein goals. i cant imagine 5/7,5/10+ mg weekly.

Are you overweight? If you already produce ample GLP/GIP it's likely you'll have a hyper response.

 

[BabaJagga]

Are you overweight? If you already produce ample GLP/GIP it's likely you'll have a hyper response.

Around 17-18-19% bodyfat. so in terms of BB, yes im fat. for general population standards, im oksy.
my goal is to not eat that much during these winter months cause i have very limited time doin sports, more seditary lifestyle. i gained weight after summer/fall ended cause of this.

i wanted to not eat that much, i have super hard time sleeping with not full stomach. In just few days, its gone.

i plan to cut under 15% before spring hits and than with lot of cycling even lower.

 

[Ghoul]

Around 17-18-19% bodyfat. so in terms of BB, yes im fat. for general population standards, im oksy.
my goal is to not eat that much during these winter months cause i have very limited time doin sports, more seditary lifestyle. i gained weight after summer/fall ended cause of this.

i wanted to not eat that much, i have super hard time sleeping with not full stomach. In just few days, its gone.

i plan to cut under 15% before spring hits and than with lot of cycling even lower.

So it sounds like you have "normal" appetite.

You're adding GLP/GIP on top of your endogenous production, which is already at a healthy level. That explains the unusually strong response.

As you decide on dosing keep in mind the mechanism of action.

Your equilibrium weight is essentially "set" by the levels of these hormones. If you're above the "weight setting" appetite suppression kicks in.

Let's say your equilibrium weight is 200lbs. With 2.5mg Tirz it's now 190. Once you reach that weight, appetite suppression will stop, To go lower, you'd increase the dose to 5mg, now it's 180, and appetite suppression will return until you get to 180.

Obviously I'm oversimplifying, but this is essentially how it works. It's changing the weight your metabolic regulating system wants you to be, and the natural processes that push you toward it (effects we collectively call "appetite") are what you experience.

So just stay at 2.5mg until you either get to your goal weight or appetite suppression stops, at which point you'd titrate up the dose,

As far as eating enough, it's all about volume, not calories. Forget regular meals. Small portions when you can handle them. Calorie dense (I gave up raw vegetables and have to cook them so they don't take up too much of the limited volume I can handle).

You'll adjust over the next few weeks.

Your best bet would be to adjust the dose as you need to lose or gain weight, but try to stay on at least a small dose continuously, There's always a dose at which you'll feel no appetite suppression at whatever weight you currently are.

At my ideal weight and 15mg Tirz I feel absolutely nothing. No sides, and a "normal" appetite that maintains a stable weight.

 

[BabaJagga]

So it sounds like you have "normal" appetite.

You're adding GLP/GIP on top of your endogenous production, which is already at a healthy level. That explains the unusually strong response.

As you you decide on dosing keep in mind the mechanism of action.

Your equilibrium weight is essentially "set" by the levels of these hormones. If you're above the "weight setting" appetite suppression kicks in.

Let's say your equilibrium weight is 200lbs. With 2.5mg Tirz it's now 190. Once you reach that weight, appetite suppression will stop, To go lower, you'd increase the dose to 5mg, now it's 180, and appetite suppression will return until you get to 180.

Obviously I'm oversimplifying, but this is essentially how it works. It's changing the weight your metabolic regulating system wants you to be, and the natural processes that push you toward it (effects we collectively call "appetite") are what you experience.

So just stay at 2.5mg until you either get to your goal weight or appetite suppression stops, at which point you'd titrate up the dose,

As far as eating enough, it's all about volume, not calories. Forget regular meals. Small portions when you can handle them. Calorie dense (I gave up raw vegetables and have to cook them so they don't take up too much of the limited volume I can handle).

You'll adjust over the next few weeks.

Your best bet would be to adjust the dose as you need to lose or gain weight, but try to stay on at least a small dose continuously, There's always a dose at which you'll feel no appetite suppression at whatever weight you currently are.

At my ideal weight and 15mg Tirz I feel absolutely nothing. No sides, and a "normal" appetite that maintains a stable weight.

thanks mate, another great reply on this topic from you.

so no upoing the dose until it works. will update here probably but im amazed how this stuff works.

my sister couldnt tolerate sema at 0,25mg/week longer than 4 weeks, 0 appetite, she had to force water down.

will see after few weeks...

 

[OldGHGuy]

This latest discussion, since I believe I am already at a "healthy" level, has me thinking to start Tirz at 1mg and titrate up from there.

 

[BabaJagga]

This latest discussion, since I believe I am already at a "healthy" level, has me thinking to start Tirz at 1mg and titrate up from there.

i would do that also knowing how strong reaction i would have.

 

[nullandvoid]

Friend of mine can't get beyond 2mg a week of Tirz, and he's been using it for months. It crushes his appetite, and he just doesn't want to eat... sometimes forgets to eat for the entire day. He's pretty fat, though. For myself, I didn't get the desired effect from Tirz until I finally got to 7.5mg. It is the perfect dose for me. Doesn't destroy my appetite but makes it trivial to satisfy. Had a body scan last week and came in at 11.9% body fat with four pounds of fat loss and only 0.4 pounds of muscle loss over three months. Pretty slow rate of loss, but it's been accelerating recently. I figured out my one standard-sized alcoholic drink a week was somehow really interrupting progress.

 

[Nested]

I would only consider adding a very small dose of Sema if 25mg Tirz is insufficient. to reach a healthy weight, which is highly unlikely. .25mg, using a separate syringe.

When you say “small dose of Sema” what amount would you recommend?

 

[Ghoul]

When you say “small dose of Sema” what amount would you recommend?

Based on my experience, start with .10mg 3 days after your weekly Tirz dose. I figured .25mg would be ok, since I've used 2.4mg in the past before switching to Tirz, and it wrecked my digestion and eliminated all appetite making eating torture (thank god I had loperamide on hand, diarrhea was severe, no exaggeration, the kind that induces life threatening dehydration). The strength of a mere .25mg Sema added to my 15mg weekly Tirz dose stunned me.

It may not do the same to you, but based on my experience I'd advise .10mg (which I found to also be very strong) and go up weekly from there if you need to.

 

[SnowyMiami]

Based on my experience, start with .10mg 3 days after your weekly Tirz dose. I figured .25mg would be ok, since I've used 2.4mg in the past before switching to Tirz, and it wrecked my digestion and eliminated all appetite making eating torture (thank god I had loperamide on hand, diarrhea was severe, no exaggeration, the kind that induces life threatening dehydration). The strength of a mere .25mg Sema added to my 15mg weekly Tirz dose stunned me.

It may not do the same to you, but based on my experience I'd advise .10mg (which I found to also be very strong) and go up weekly from there if you need to.

You changed your tune. You were telling people to follow the pharma protocols two weeks ago.

 

[Luke391]

First kit of tirz arrived today, gonna start on sunday.
I know the info is here but I'm neurotic about this stuff so I just wanna make sure.

1) Can I keep non reconstituted tirz out of the fridge?

2) Can I keep unopened BAC water out of the fridge?

3) Is tirz fragile like other peptides? Like if it gets shook around a bit when in the fridge is it an issue?

4) Other than Phyllium husk what other supps you guys reccoment with tirz?

5) When riconstituting tirz, should I inject the water first and then air, or the other way around?

Thank you very much.

 

[Juiced_lizard]

First kit of tirz arrived today, gonna start on sunday.
I know the info is here but I'm neurotic about this stuff so I just wanna make sure.

1) Can I keep non reconstituted tirz out of the fridge?

2) Can I keep unopened BAC water out of the fridge?

3) Is tirz fragile like other peptides? Like if it gets shook around a bit when in the fridge is it an issue?

4) Other than Phyllium husk what other supps you guys reccoment with tirz?

5) When riconstituting tirz, should I inject the water first and then air, or the other way around?

Thank you very much.

1 - I store my tirz (and other peptides) just in a cool dark place

2- yes store bac water in the same spot as my peptides.

3- I think the shaking is a myth personally. Now I wouldn’t throw it off a building. But shaking around in a fridge? No

4- I take other vitamins not necessarily with tirz in mind. Milk thistle, omega 3, creatine, NAC, and some others.

5- I inject the amount of water I want then when I’m ready to get a dose out I pull that syringe with the amount of air needed for that dose then inject that amount of air into the vial and pull my dose as usual.