MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Yeah it's tirzepatide mostly, group of ppl did lots of testing at Jano proving all the things I just said above. Tirzepatide is the superman of peptides lol
Ghoul
Member
Jano's testing leaves a lot to be desired in terms of detecting what constitutes degradation.
There's more to it than just purity.
All pharma peptides that come reconstituted, Tirz, Sema, rHGH, Insulin are supposed to be discarded after a freeze thaw cycle.
Monomer may only drop a tiny amount in purity testing after freeze / thaw, but other testing methods have shown massive increases in micrometer sized particles in peptide solutions (unless freeze damage prevention excipients are used).
Well ok don't freeze and thaw it multiple time (I don't see the reason to freeze anything reconstitued anyway) still degradation reconstitued after 3+ months was close to 0.
We can go only by the tests we have and that's purity and quantity of the specific sample.
Hard to say of anything less or more for something we can't test for.
And btw HGH got destroyed on that test and othe peptides too, Tirzepatide didn't. Take that information as you wish
explodingHeart
Member
Let's assume that's true. So what can we do? Always filter after reconstituting?
Or re-filter every week?
the~club~bro
New Member
I find this topic of peptide freezing to be fascinating. My own anecdotal experience: back in the day I bought MT2 from datbtrue. I dont need much MT2 to ilicit the response I want. With the remaining MT2 I prepared prefilled insulin needles and threw them in the freezer. The next summer, those frozen MT2 doses definitely still worked once left to thaw in the fridge. n=1 and a different compound but still, very interesting. Having said that, I wouldn't do that again and would much prefer to be using pharma grade sema or tirz from a fresh pen.
Given all the drama in their thread with bunk gear, bad shipping, lack of communication and other reports i'd stay with other sources such as Opti.
OldGHGuy
Member
I am in the first month of starting UGL Tirz, still on 2.5MG and just used my 3rd shot of a 10MG vial. This week I have noticed significant degradation in the product and have actually gained a few pounds back. This could be simply a sort of rebound effect after initially starting I suppose but reading about degradation UGL vs Pharma has me thinking degradation. One more pin left in the vial and then up to 5MG (which will only be 2 shots per vial) so not really worrying too much about it moving forward
It's all in your mind unless the tirz you bought is shit.. tirz doesn't show any significant degradation after 3+ months.
2.5 is not even the minimum dosage but just the starting one. Increase dosage.
My wife use 50mg tirz vial and use only 5mg every week and her BG stays perfectly in check and the same all the way till the end of the vial.
In short words: you are wrong
OldGHGuy
Member
Wrong about what, exactly? I just provided a description of my experienceIt's all in your mind unless the tirz you bought is shit.. tirz doesn't show any significant degradation after 3+ months.
2.5 is not even the minimum dosage but just the starting one. Increase dosage.
My wife use 50mg tirz vial and use only 5mg every week and her BG stays perfectly in check and the same all the way till the end of the vial.
In short words: you are wrong
Ghoul
Member
It's all in your mind unless the tirz you bought is shit.. tirz doesn't show any significant degradation after 3+ months.
2.5 is not even the minimum dosage but just the starting one. Increase dosage.
My wife use 50mg tirz vial and use only 5mg every week and her BG stays perfectly in check and the same all the way till the end of the vial.
In short words: you are wrong
Not every formulation has the same stability.
This Tirz dropped almost 2% in purity in just weeks, LYOPHILIZED.
The very basic testing that Jano does for these small private groups does not overturn the facts that thousands of scientists who develop and work with peptides every day have established over 60 years.
Hello everyone,
I am somehow in a terrible situation, and I need your honest and wise advices regarding the issue.
As you know, I initiated several Group buys, tested first, then I covered the testing costs of volunteers.
For these Group Buys, I announced a +99% purity guarantee.
The first one was Tirzepatide 10mg, here is my test:
The second one was BPC157 10mg, and here is my test:
Now, the...
I am somehow in a terrible situation, and I need your honest and wise advices regarding the issue.
As you know, I initiated several Group buys, tested first, then I covered the testing costs of volunteers.
For these Group Buys, I announced a +99% purity guarantee.
The first one was Tirzepatide 10mg, here is my test:
The second one was BPC157 10mg, and here is my test:
Now, the...
I'm starting to think if some $200 test from Jano demonstrated gravity didn't exist some would believe it.
Last edited:
Ghoul
Member
You can take steps to try and reduce immune response,
Filtering after reconstituting would help.
Reducing "exposure events", ie, minimizing injection frequency helps,
Using a more dilute solution helps. .5ml volume per dose (or larger) for Tirz.
Pharma takes steps not to entirely eliminate immune response, since it's unavoidable to some degree, but to keep it low enough it doesn't become "clinically significant", ie, the drug works well enough the desired effect is retained, even if it's lessened slightly by the immune system destroying some of it.
Exenatide is an example of a GLP where a certain percentage of patients develop increasing immunogenicity over time, and they slowly lose glucose control, eventually needing to switch drugs.
You are nitpicking, QSC openly stated that they had issue in the formulation at first and peptides were degrading fast, they fixed it not much later that post.Not every formulation has the same stability.
This Tirz dropped almost 2% in purity in just weeks, LYOPHILIZED.
The very basic testing that Jano does for these small private groups does not overturn the facts that thousands of scientists who develop and work with peptides every day have established 60 years.
Hello everyone,
I am somehow in a terrible situation, and I need your honest and wise advices regarding the issue.
As you know, I initiated several Group buys, tested first, then I covered the testing costs of volunteers.
For these Group Buys, I announced a +99% purity guarantee.
The first one was Tirzepatide 10mg, here is my test:
The second one was BPC157 10mg, and here is my test:
Now, the...
I'm starting to think if some $200 test from Jano demonstrated gravity didn't exist some would believe it.
I have acces to something like hundred of purity/quantity test of lyophilised Tirzepatide and other peptides kept in fridge or freezer for long time and degradation has been always minimal, reconstituted Tirzepatide there are at least 5 different tests done on 5 different sources and all shown the same, no significant degradation after months of reconstitution.
Again take it as you want.
Ghoul
Member
As you lose weight, the effect at a given dose lessens, and you plateau with minor variation of a few pounds in weight. Ultimately you reach a "maintenance dose". But if you're steadily returning to starting weight, that would indicate a loss of effectiveness.
Your experience is full of feelz report, you have no proof it degraded, you are just assuming that because you don't feel the appetite suppression it's degraded but that's factually wrong at 99%.
You just got used to 2.5mg dosage, so you need to increase to get the appetite suppression again.
If we follow your logic my friend that I gave him a vial of 50mg Tirzepatide and never felt anything at 2.5mg should have called it bunk, too bad when he increased at 5mg from the same vial 4 weeks later he stopped eating and got hit hard.
See where I'm going?
Last edited:
One can easily out eat Glp1, plenty of ppl proving it around here.
Many of us have maintained the same dosage and increased our weight and got no suppression effect with times.
Same dosage that was giving use a suppression effect at first
Appetite suppression is a side effect, body get used to it.
Ask @Trenbolonetax he bulked on 15mg of Tirzepatide lol
If your theory was correct he would have not being able to do it. He is not the only one, my wife couldn't eat shit at 5mg now she increased her weights more and she can eat normally still at 5mg.
Glucose control stayed the same so effectiveness is there, just not the appetite suppression.
Trenbolonetax
Member
I'll outeat tirz or reta at max dose and put myself into a caloric surplus without too much difficulty. I did this at 250 I did this at 305.
But the difference is I don't have to eat, but I can, with Reta at least.
But yes the appetite suppression definitely decreased, and it decreased faster when I was fighting it and gaining.
Exactly, it works for obese ppl because at first it gives you a signal of not eating and so they embrace it and don't eat and lose weight but if you are set on eating with times and if you fight eat you can eat more and gain weight even at higher dosages.
I feel like you can't still eat like crazy crazy because the slow gastric emptiness and feeling full faster it still linger but the more times it pass the less you have that too.
But a person set on a goal can easily out eat it.
Is it easy? Not always but it can be done.
The substance is still working because glucose control is still excellent and other stuff are still there but most of the side effect goes away for the big part. Of course if you go on a binge there will be a moment where you will get punished at least for me
You explained perfectly: I don't have to eat, I just force myself in doing it and it does allow me to do it.
I could skip few meals if I wanted without feeling like: shit I'm hungry as fuck I wanna eat a cow!!!
But I don't wanna skip those meals and so I just eat anyway.
Trenbolonetax
Member
Definitely. Tirz physiologically prevented me from eating more due to the slowed gastric emptying. So it was much more uncomfortable to shovel food on it compared to Reta. However, the Reta acid reflux was brutal at first, lol.
Agreed; with time and eating with purpose, it speeds back up.
Yes...definitely. Big enough binge and I will definitely be punished; not severely, but enough that I don't want to binge that hard.
Yup! Some days I'll decide to fast until lunch (rest day anyhow), and it's not difficult at all. Other days I'm eating ASAP in the morning. Love the flexibility it offers me.
Similar threads
- Question
Sponsors
Latest posts
-
-
-
Sigma Audley Inc. - Your source for peptides, ancillaries, AAS, and more!
- Latest: Proud Pangolin
-
-