Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Sampei]

And to add one thing, I believe Tirzepatide is superior for bulking compared to retatrutide. Especially because it has a better insulin sensitivity effect and helps in the storage of glycogen instead reta with the glucagon part of it, when you are trying to lower the BG it doesn't allow it after a certain point as it keeps trying to bring you in ketosis all the time while releasing glucose and fats from the liver. I feel it does flatten you a lot more than Tirzepatide and I for me it is a lot more suited for a cut, the only issue with Tirzepatide is that it's harder to outeat it compared to reta.

My wife had amazing results on her last bulk on Tirzepatide. For the first time after few years where she was stuck she finally packed up at least 5lbs of muscle and and in the meantime she maintained her BF completely unchanged.

Her ass legs and lower body finally got some well deserved meat, her muscle are a lot more hard and cut and she went from not being able to eat to increase her maintenance calories by 500/600kcal that for a woman is not small feat (especially a small one).

on a 5mg Tirzepatide from start to finish.

 

[Trenbolonetax]

And to add one thing, I believe Tirzepatide is superior for bulking compared to retatrutide. Especially because it has a better insulin sensitivity effect and helps in the storage of glycogen instead reta with the glucagon part of it, when you are trying to lower the BG it doesn't allow it after a certain point as it keeps trying to bring you in ketosis all the time while releasing glucose and fats from the liver. I feel it does flatten you a lot more than Tirzepatide and I for me it is a lot more suited for a cut, the only issue with Tirzepatide is that it's harder to outeat it compared to reta.

My wife had amazing results on her last bulk on Tirzepatide. For the first time after few years where she was stuck she finally packed up at least 5lbs of muscle and and in the meantime she maintained her BF completely unchanged.

Her ass legs and lower body finally got some well deserved meat, her muscle are a lot more hard and cut and she went from not being able to eat to increase her maintenance calories by 500/600kcal that for a woman is not small feat (especially a small one).

on a 5mg Tirzepatide from start to finish.

I was actually just thinking about this.

I think it would be optimal to run Tirz on a bulk for the reasons you listed, but out eating it would be tough so it would take some "stretch training"

Agreed; reta on a cut.

If someone could proper clean bulk carb cycle on tirz + slin + gh...that would probably lead to phenomenal results.

I wonder though, not that one would do this, but bulking on a low carb diet + reta. Given it's propensity to drive someone further into ketosis, maybe in that context reta would be better than tirz.

 

[Sampei]

I was actually just thinking about this.

I think it would be optimal to run Tirz on a bulk for the reasons you listed, but out eating it would be tough so it would take some "stretch training"

Agreed; reta on a cut.

If someone could proper clean bulk carb cycle on tirz + slin + gh...that would probably lead to phenomenal results.

I wonder though, not that one would do this, but bulking on a low carb diet + reta. Given it's propensity to drive someone further into ketosis, maybe in that context reta would be better than tirz.

Bulk on a keto diet, that's the way to use reta for a bulk imho. High fat, moderate protein, low carb.

And when one want to cut just reduce the total calories, reduce fat, increase protein and keep carbs low.

Problem is... It's very hard to bulk on high fat and Glp1. Every time I have an heavy fat meal my digestion is so slow that I feel full for hours after hours. Instead if I eat low fat/no fat high carb high protein I can keep eating easily because I digest it quickly compared to a meal with fat in it.

This principle works normally but on Glp1 it's 10x stronger.

 

[Sampei]

What about maybe low tirz dosage, max 10mg or maybe even less like 5mg just to reap the glucose control and less inflammation etc benefits without hindering the gastric system much?

 

[FuriousGrill]

What about maybe low tirz dosage, max 10mg or maybe even less like 5mg just to reap the glucose control and less inflammation etc benefits without hindering the gastric system much?

I'll be starting a progressive phase log doing exactly this in just a few weeks!

 

[Ghoul]

What about maybe low tirz dosage, max 10mg or maybe even less like 5mg just to reap the glucose control and less inflammation etc benefits without hindering the gastric system much?

Considering diabetics are taken off insulin and put on 2.5mg Tirz for a month, then 5mg Tirz for another month, there should be decent glucose control even at those low doses.

I've never felt any impact on appetite below 10mg, but that was after using Sema up to 2.4mg. Then there are guys who are crippled by 2.5mg Tirz, but that's very rare.

 

[Nidus]

And to add one thing, I believe Tirzepatide is superior for bulking compared to retatrutide. Especially because it has a better insulin sensitivity effect and helps in the storage of glycogen instead reta with the glucagon part of it, when you are trying to lower the BG it doesn't allow it after a certain point as it keeps trying to bring you in ketosis all the time while releasing glucose and fats from the liver. I feel it does flatten you a lot more than Tirzepatide and I for me it is a lot more suited for a cut, the only issue with Tirzepatide is that it's harder to outeat it compared to reta.

My wife had amazing results on her last bulk on Tirzepatide. For the first time after few years where she was stuck she finally packed up at least 5lbs of muscle and and in the meantime she maintained her BF completely unchanged.

Her ass legs and lower body finally got some well deserved meat, her muscle are a lot more hard and cut and she went from not being able to eat to increase her maintenance calories by 500/600kcal that for a woman is not small feat (especially a small one).

on a 5mg Tirzepatide from start to finish.

I am at 10mg Tirza e5d atm and my glucose has never been more stable. I love it!

Also using Jardiance and Metformin but its amazing on how much my Blood glucose levels have improved (more stable and already a slight change in hba1c and homa after just a month)

 

[Luke391]

u guys put water first or air first in the glp1 vials?

 

[Ghoul]

u guys put water first or air first in the glp1 vials?

Let the vacuum pull the water in BUT, ensure the needle points to the sidewall of the vial, and hold onto the plunger to keep the flow slow. You don't want bubbles or foam.

 

[Leona]

What the fuck mate, hijacking the thread and discussion we are having asking for sources and other stuff?

Don't you do it again, delete the post and we will call it a mistake of a newbie.

all good lad deleted i apologize was a retarded to do that thought i was in an other thread also

 

[Sampei]

u guys put water first or air first in the glp1 vials?

I pierce the vial with a needle first, let the vacuum dissipate then I inject the water slowly. Letting the water in with the vacuum create too many chances of foam and bubble no matter how you do it.

 

[Country Club Hero]

And to add one thing, I believe Tirzepatide is superior for bulking compared to retatrutide. Especially because it has a better insulin sensitivity effect and helps in the storage of glycogen instead reta with the glucagon part of it, when you are trying to lower the BG it doesn't allow it after a certain point as it keeps trying to bring you in ketosis all the time while releasing glucose and fats from the liver. I feel it does flatten you a lot more than Tirzepatide and I for me it is a lot more suited for a cut, the only issue with Tirzepatide is that it's harder to outeat it compared to reta.

My wife had amazing results on her last bulk on Tirzepatide. For the first time after few years where she was stuck she finally packed up at least 5lbs of muscle and and in the meantime she maintained her BF completely unchanged.

Her ass legs and lower body finally got some well deserved meat, her muscle are a lot more hard and cut and she went from not being able to eat to increase her maintenance calories by 500/600kcal that for a woman is not small feat (especially a small one).

on a 5mg Tirzepatide from start to finish.

I agree based on my experiences with those compounds too. However, I can report the ravenous hunger brought on by EQ has been enough to overpower the appetite suppression from Tirz.

I am shocked as I didn’t think any steroids would be available to create a hunger capable of overpowering a good dose of Tirz. And I know my Tirz is good. And only running the EQ at 500mg.

 

[Sampei]

I agree based on my experiences with those compounds too. However, I can report the ravenous hunger brought on by EQ has been enough to overpower the appetite suppression from Tirz.

I am shocked as I didn’t think any steroids would be available to create a hunger capable of overpowering a good dose of Tirz. And I know my Tirz is good. And only running the EQ at 500mg.

Good to know

 

[OldGHGuy]

Interesting trial upcoming:

Carebox Connect

Match and refer to clinical trial treatment options for a condition.

connect.careboxhealth.com

 

[Sampei]

Interesting trial upcoming:

Carebox Connect

Match and refer to clinical trial treatment options for a condition.

connect.careboxhealth.com

Too bad the dose used for the HGH is ridiculously low

 

[RAW95]

I have no dog in this fight but for what it's worth...I have also seen no difference in Pharma (Omnitropin) and generics. I am a hyper responder

Sorry brother. Dont take my comment (which I ammended) as a negative. I am a hyper responder to everything

I am a hyper responder though

My numbers are in the 400's on 2iu (although I am a hyper responder).

2.5mg daily works great for me. Never had a need to go higher (but I am hyper responder to everything)

Thanks brother. Great data. I will let you know how it goes. I think 3:1 is a great starting point for me just because I'm a hyper-responder to everything.

Idk - I'm a hyper-responder but I'm losing about a pound a day on UGL Tirz right now at 2.5 mg with virtually no sides

I bet he is a hyper responder.

 

[Sampei]

I bet he is a hyper responder.

I had miss the ridiculousness of all this shit xD
Thanks mate I had a good laugh

 

[SubparMarioBro]

And to add one thing, I believe Tirzepatide is superior for bulking compared to retatrutide. Especially because it has a better insulin sensitivity effect and helps in the storage of glycogen instead reta with the glucagon part of it, when you are trying to lower the BG it doesn't allow it after a certain point as it keeps trying to bring you in ketosis all the time while releasing glucose and fats from the liver. I feel it does flatten you a lot more than Tirzepatide and I for me it is a lot more suited for a cut, the only issue with Tirzepatide is that it's harder to outeat it compared to reta.

My wife had amazing results on her last bulk on Tirzepatide. For the first time after few years where she was stuck she finally packed up at least 5lbs of muscle and and in the meantime she maintained her BF completely unchanged.

Her ass legs and lower body finally got some well deserved meat, her muscle are a lot more hard and cut and she went from not being able to eat to increase her maintenance calories by 500/600kcal that for a woman is not small feat (especially a small one).

on a 5mg Tirzepatide from start to finish.

Reta has a much better insulin sensitivity improvement than tirz. 39% improvement in the diabetes trial, 52% improvement in the obesity trial. For comparison in the Surpass-2 trial tirz only has a 24% improvement for diabetics and I have no info for obesity.

Reta’s GCGR targeting causes depletion of hepatic glycogen stores. The muscular stores are unaffected by this action.

 

[AlexDavis43]

Bulking on a high fat keto diet is retarded.

If the keto diet is not high fat, then it's PSMF, and is also retarded for bulking.

 

[Sampei]

Reta has a much better insulin sensitivity improvement than tirz.

View attachment 321185

Reta’s GCGR targeting causes depletion of hepatic glycogen stores. The muscular stores are unaffected by this action.

Very interesting finding, thank you!

I just delves more into it and it seems you are correct on the insulin sensitivity even so Tirzepatide achieve a slighter higher hbA1c reduction it seems the insulin sensitivity increase in reta is superior.

One thing I found interesting is there was no HOMA2-B increase (C-peptide) in the obesity group Vs the T2D group. I wonder why... But I have no clue.

Tho it's hard to say who's better for bulking and who does react better to a moderate high carb diet.