Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Luke391]

Hey bro DM me ill tell u where to go to smaller increments of what your looking for

what?

 

[Luke391]

Any experience with doing Tirz + Cagri?
I'm gonna another order because I'm running out of Tirz and I have to up my dose and was thinking of Carilitide maybe, I've heard people say it has more of a "mental" suppresion of food noise. Any experience with it?

 

[explodingHeart]

Are we finally through the phase of guys on tren who say it's not masculine or skipping hard work if you use GLPs?

That was the cringiest god awful shit ever. Of course those guys flip flop with other influencers start promoting GLPs.

 

[Doodle]

Any experience with doing Tirz + Cagri?
I'm gonna another order because I'm running out of Tirz and I have to up my dose and was thinking of Carilitide maybe, I've heard people say it has more of a "mental" suppresion of food noise. Any experience with it?

I also would like to know. I have a kit of cag coming in a few days.

 

[Luke391]

Are we finally through the phase of guys on tren who say it's not masculine or skipping hard work if you use GLPs?

That was the cringiest god awful shit ever. Of course those guys flip flop with other influencers start promoting GLPs.

there's still some people but we are gettting over it

 

[explodingHeart]

there's still some people but we are gettting over it

They'll flip flop after their influencer g4p bodybuilder buddies on instagram start getting paid to promote "research peptides".

Then all of the sudden GLPs will be "natural" and "perfectly fine" to use.

 

[PiscesMoon]

Has anyone else felt extreme soreness after tirzepatide?

I had been on semaglutide over a year ago. Eventually switched to tirzepatide and did well on it. Recently though I was doing mazdutide to see what that was like. Since QSC is gone I can’t find anywhere to stick with maz. I decided to go back to tizepatide . I started low at 2.5mg injected yesterday. Today I feel like I got hit by a truck. I am sore absolutely everywhere. It hurts to touch my body. It doesn’t feel like aches from an illness. It feels like I did the biggest work out of my life and all my muscles are screaming. I didn’t have this side effect at all with anything I’ve done before.

It’s not a deal breaker, but im wondering who else experienced this.

Hi @Doodle Yes the experience you described happens to some people from their starting dose of Tirzepatide. The feelings of being sore, being hit by a truck, is familiar. This kind of extreme soreness seems to happen only on the first dose of Tirzepatide.

How are you feeling now? Have you continued with the Tirzepatide?

 

[rosky71]

Has anyone else felt extreme soreness after tirzepatide?

I had been on semaglutide over a year ago. Eventually switched to tirzepatide and did well on it. Recently though I was doing mazdutide to see what that was like. Since QSC is gone I can’t find anywhere to stick with maz. I decided to go back to tizepatide . I started low at 2.5mg injected yesterday. Today I feel like I got hit by a truck. I am sore absolutely everywhere. It hurts to touch my body. It doesn’t feel like aches from an illness. It feels like I did the biggest work out of my life and all my muscles are screaming. I didn’t have this side effect at all with anything I’ve done before.

It’s not a deal breaker, but im wondering who else experienced this.

I just did my first injection of Tirz yesterday. 2.5mg. woke up today and it hurts to move around. After sitting and having to get up takes a good 30 steps to actually feel like I can move normally. Also getting sulfur burps. But this is the first time in life that I am actually not hungry or thinking about food. I feel like I have to force feed while in a cut

 

[Doodle]

Hi @Doodle Yes the experience you described happens to some people from their starting dose of Tirzepatide. The feelings of being sore, being hit by a truck, is familiar. This kind of extreme soreness seems to happen only on the first dose of Tirzepatide.

How are you feeling now? Have you continued with the Tirzepatide?

I’m much better. It went away the next day. I haven’t had soreness or any bad side effects since then.

 

[PiscesMoon]

I’m much better. It went away the next day. I haven’t had soreness or any bad side effects since then.

Right on. Glad all is well now after that first-time soreness.

 

[Wizbang]

What have been peoples experiences with Mazdutide? and how would you compare it to Tirz ?

 

[CubanQuentin]

I recently came across a box of dulaglutide (trulicity). Is it worth it starting on that while I wait for sema to ship?

 

[Luke391]

I recently came across a box of dulaglutide (trulicity). Is it worth it starting on that while I wait for sema to ship?

in my opinion just wait for sema

 

[sushak]

What have been peoples experiences with Mazdutide? and how would you compare it to Tirz ?

Been on it a few months, at 10mg per week, barely feel it. Once it's finished I'm going back to sema.

 

[CubanQuentin]

in my opinion just wait for sema

Kinda feels like a waste since I got the box for free. I was hoping to use it as the "starting dose", as to jump straight to the 0,5 mg of sema instead of starting at 0,25. Is it not effective/worth it even for that purpose?

 

[Luke391]

Kinda feels like a waste since I got the box for free. I was hoping to use it as the "starting dose", as to jump straight to the 0,5 mg of sema instead of starting at 0,25. Is it not effective/worth it even for that purpose?

GLP1s are complex, I wouldn't use them willy nilly. Do the pahrma grade protocol of sema, the mazdutide can last a long time, maybe you could add it on top of sema after some time but don't use them on and off like other drugs

 

[SubparMarioBro]

Kinda feels like a waste since I got the box for free. I was hoping to use it as the "starting dose", as to jump straight to the 0,5 mg of sema instead of starting at 0,25. Is it not effective/worth it even for that purpose?

They often use dulaglutide as a control drug for other GLP-1s and it’s pretty underwhelming. For example, here’s retatrutide (various doses) vs dulaglutide vs placebo.



Dulaglutide (red) managed to lose to placebo.

 

[The_Thinking_Elf]

2.50mg is "safer" in terms of avoiding unpleasant GI sides if you're one of the rare hyper responders.

But the majority of males don't feel anything at 2.5mg in my experience.

This is me. I have been on 2.4mg/week for the last 10 weeks because the suppression was so significant. No real reason to increase dosage.

A few side effects:

1. Sulphur burps (fixed with moving to smaller meals)
2. Stools looked a bit weird (fixed with more water and some fiber)
3. Some nausea (first few weeks)(went away on its own)

I am using the pharma version (pen)

 

[RAW95]

I had my first Tirzepatide shot 4 days ago.


The appetite suppression was very noticeable by the end of the first day.
I’ll stay on 2.5 mg/week for the first 4 weeks and then adjust accordingly.


Today, on day 4, I feel the suppression is even stronger.


I only had 2 meals the whole day, and even though I felt hungry before the second one, I ate clean and had an average portion — and it made me feel pretty full.


Also, I have no cravings or food noise.
The difference it has made in just these 4 days is phenomenal.

 

[Ghoul]

I had my first Tirzepatide shot 4 days ago.


The appetite suppression was very noticeable by the end of the first day.
I’ll stay on 2.5 mg/week for the first 4 weeks and then adjust accordingly.


Today, on day 4, I feel the suppression is even stronger.


I only had 2 meals the whole day, and even though I felt hungry before the second one, I ate clean and had an average portion — and it made me feel pretty full.


Also, I have no cravings or food noise.
The difference it has made in just these 4 days is phenomenal.

Expect it to be stronger a few days after the 2nd dose as blood levels continue to increase (you're building on the residual amount left from the previous dose).

Feel free to stay on that dose as long as you're moving toward your goal. As weight drops, appetite suppression (and side effects) will diminish and you can titrate to the next level.