Gonadorelin during cycle instead of HCG

[Yuri Sa]

Does anyone have any experience with gonadorelin (GNRH) used during cycle to avoid the suppression of the the pituitary and the testicles?

There's an old post here advocating the use of 1200 mcg of gonadorelin (nasal spray 3x a day, Kryptocur) but I didn't see any actual log.

Maybe this this can work really well, both to avoid the supression of the pituitary and the testicles ( avoiding this way the use of HCG, HMG and even the triptorelin experiments), and that's probably will make recovery much faster. I read some studies using GNRH pulses in people with HH using much lower doses than the above recommended (phisiological doses of 5 mcg every 90 minutes). And still others presenting data (including with people receiving TRT) that 5 mcg 3 times a day was enough to preserve the pituitary functionality. And this daily dose is 4000 tomes lower (in potency) than the 100 mcg trip and there's no risk of pituitary downregulation with this dose.

 

[master.on]

I wouldn't use neither HCG or GnRH during cycle.
Leave 'em for PCT.
AFAIK gonadorelin ain't banned like HCG is (in some states) so you can easily get legit pharma gonadorelin. It is also available in veterinary form.

BTW gonadorelin WILL downregulate the pituitary.
Just google Leuprorelin
Leuprorelin - Wikipedia, the free encyclopedia
It is an GnRH analog used to reduce test for prostate cancer.
At first it will increase HCG and test (hence the worsening of prostate symptoms warning) but later it will shut down HCG and test for several months.

So it looks like the big advantage of GnRH is only legal.

 

[Yuri Sa]

I read a lot of studies. All the GNRH agonists are much more potent than Gonadorelin (that IS GNRH) and stays longer in the pituitary. Most of them actually were created with the intention of downregulate the pituitary. The pituitary is downregulated by an excess of "GNRH" AND GNRH dosed in a High frequency cycle (or a stable dose of GNRH analog, like trip).

That's the problem with people using triptorelin. Trip is used for downregulating the pituitary with a dosage of 1,5 mg a month. To achieve the same results, people need to use 0,5 mg of buserelin a day. Buserelin stimulated the pituitary 50 to 60 times more than gonadorelin. Besides that, I don't know how long does trip estimulates.


In smaller dosages there's acutally people using gonadorelin for hypogonadism, delayed puberty and other stuff. There's a study using 5 mcg every 90 minutes, 4 mcg every 90 minutes, 50ng/kg in different cycle dosages (going from each 120 minutes to each 8 hours). There's also usage in 400 mcg/8 hours with a nasal spray (bioavability of 1~3% compared to intravenous). There're also studies with buserelin (an analog, 50 to 60 times more potent). There's study using 5 mcg every 8 hours via nasal spray, 15 mcg every 8 hours via nasal spray, 100 mcg every day etc. None of this studies presented any downregulation of the pituitary.


The problem is that here in Brazil it's impossible to find a high dosage gonadorelin spray and I don't want to risk a lower dosage analog (because it's kind a hard to find the lower dosage pharmacokinetics of Buserelin). I found only 500 mcg gonadorelin (too small dosage for spray) and I don’t want to inject myself 5 mcg 3 times a day. So maybe I will try just a one pituitary stimulus test with 10 mcg of GNRH 3 times a day for 2 or 3 days in the end of the cycle (the total dosage would be almost the physiological dosage of a guy without cycle and it’s much smaller than the 100 mcg trip used (without success). If I could find the gonadorelin spray I probably would try during cycle.

 

[master.on]

I'm pretty sure you can find veterinary GnRH in Brazil.
If I'm not mistaken Conceptal by Intervet

 

[Michael Scally MD]

No.

 

[Yuri Sa]

Sorry doc, are you saying that there's no experiences/log or there's no presumed benefits?

 

[master.on]

No.

Sorry doc, are you saying that there's no experiences/log or there's no presumed benefits?

Or that you didn't find any veterinary GnRH in Brazil?
LOL