HGH Red Welts

[tmerrill]

Hey there - new to the game of HGH and have ordered through several sources. I am getting red welts at injection site - done tons of research and really not sure what to believe. Do I stop using, push through it as it will get better, dilute with 2ml water vs 1ml, etc... I did use some pharma grade and no reaction, so do I just have "dirty" HGH? strange that everone i have used (Hygetropin, Sitropin, Pharmatropin) give me a reaction.

thanks for your feedback and guidance - 3IU each morning is what I am using.

 

[Burleyboyz]

Everything I’ve read about the red welts says it could either be a 192aa you’re shooting or something wrong with the manufacturing process leaving E.coli in the vial. Some people say diluting it more with BAC works other say it doesn’t.

Sorry if that isn’t any help, I’d try recon. with 2ml if you’re set on continuing the kit

 

[tmerrill]

Everything I’ve read about the red welts says it could either be a 192aa you’re shooting or something wrong with the manufacturing process leaving E.coli in the vial. Some people say diluting it more with BAC works other say it doesn’t.

Sorry if that isn’t any help, I’d try recon. with 2ml if you’re set on continuing the kit

Thanks for the reply - yea that is what I have heard as well

 

[Dr JIM]

And why is it this type of a reaction rarely if ever occurs with Pharma???

 

[janoshik]

Everything I’ve read about the red welts says it could either be a 192aa you’re shooting or something wrong with the manufacturing process leaving E.coli in the vial. Some people say diluting it more with BAC works other say it doesn’t.

Sorry if that isn’t any help, I’d try recon. with 2ml if you’re set on continuing the kit

There is no 192aa on the market and there is no realistic way that E. Coli is left in the vial.

There might be endotoxin, a part of E. Coli membrane, left, though.

 

[Burleyboyz]

There is no 192aa on the market and there is no realistic way that E. Coli is left in the vial.

There might be endotoxin, a part of E. Coli membrane, left, though.

You know what I meant with the e.coli and there’s no way you can say there’s no 192aa on the market

 

[janoshik]

You know what I meant with the e.coli and there’s no way you can say there’s no 192aa on the market

Show me evidence showing otherwise and I'll gladly change my stance.

Thank you.

 

[Burleyboyz]

I don’t care about your stance, and neither does any of the informed people on this bored.

You’re welcome.

 

[janoshik]

I don’t care about your stance, and neither does any of the informed people on this bored.

You’re welcome.

And like most of the "informed people" you are most likely referring to, you lack arguments and instead you refer to others as a source of validation.

I think that's a trait typical for women, m'lady.

 

[Platinum Direct]

Try shooting IM and make sure ur using bac water that is not expired

 

[Burleyboyz]

Damn good insult bro

 

[Dr JIM]

Bc the rHGH manufactured and secreted by E-coil is less then perfect a certain degree of "incomplete" proteins, PEPs and peptides are also produced.

These incomplete proteins is most likely responsible for the "welts" some experience when running GGH.

And bc of the possibility of "allergic reactions" Pharma uses a variety of processes such as ultrafiltration to electrophoresis to greatly minimize the risks of "foreign protein exposure" on behalf of patients.

 

[Senorman]

And why is it this type of a reaction rarely if ever occurs with Pharma???

This.

I got red welts (I looked like I’d attacked a beehive with my stomach) with hygetropin, threw that shit in the trash. With seros, I’ve never had a single welt.

 

[ChestRockwell]

Try shooting IM and make sure ur using bac water that is not expired

Someone's body is showing clear signs of agitation and we would therefore recommend they take it up a notch by going intramuscular?

 

[ProfessorX]

I agree with Jim, Jano and Chest

If it's one of the cheap "Generic" GH products causing welts at the site injection everytime, then its possibly/probably a higher amount of endotoxins present than what's normally allowed in legit PHARMA GH ( endotoxin levels to 0.5 EU/µg or less)

A final "purifying process" in manufacturing the Synthetic Protein (HGH) is skipped or not done well to provide a "Cheap Chinese Generic GH Product"

Endotoxins (lipopolysaccharides, LPS) are major contaminants found in commercially available proteins or biologically active substances. LPS are highly potent immune stimulators able to cause side effects

Purification very often represents the most time consuming and cost intensive step of the whole production process. Therefore optimization of the downstream process is essential in order to achieve time and cost efficiency (3). Generally, high LPS concentrations can be reduced to about 100 EU/mL without special treatment, but many applications require an even lower-limit value as described within the pharmacopoeia — e.g., 5 endotoxin units (1 EU ≈ 100 pg) per kilogram of body weight per hour for intravenous applications.

Endotoxin Testing Analysis and Removal - Bio-Synthesis, Inc.

Bacteria pyrogen such as endotoxins, also called lipopolysaccharides (LPS), are major contaminants found in commercially available proteins or biologically active substances. This bacterial endotoxin is a potent stimulator of the mammalian immune system in vivo, and it may decrease tissue culture cell viability and inhibit transfection efficiency in vitro.

Also, bacterial residue in low grade Somatropin or Somatrem (192) can cause reactions

(I agree with jano that 192 is no longer common on the black market)

Painful red welts on injection spot can be caused by low quality growth hormone which contain too much bacterial residue (Endotoxins ((lipopolysaccharides, LPS)). This can lead to serious problems where the body could eventually develop resistance (Protein Immunogenicity) even against its own naturally produced growth hormone. (Immune response similar to Somatrem)
If the welts appear after every injection and persist for a day or two, then you should discontinue use

Injecting IM (BroScience) to elimate the reaction isn't best IMO

 

[Dr JIM]

Bc the rHGH manufactured and secreted by E-coil is less then perfect a certain degree of "incomplete" proteins, PEPs and peptides are also produced.

These incomplete proteins is most likely responsible for the "welts" some experience when running GGH.

And bc of the possibility of "allergic reactions" Pharma uses a variety of processes such as ultrafiltration to electrophoresis to greatly minimize the risks of "foreign protein exposure" on behalf of patients.

What is the "risk" IDK but standard medical practice suggests its best to avoid any drug that results in an "allergic reaction".

JIM

 

[Dr JIM]

I agree with Jim, Jano and Chest

If it's one of the cheap "Generic" GH products causing welts at the site injection everytime, then its possibly/probably a higher amount of endotoxins present than what's normally allowed in legit PHARMA GH ( endotoxin levels to 0.5 EU/µg or less)

A final "purifying process" in manufacturing the Synthetic Protein (HGH) is skipped or not done well to provide a "Cheap Chinese Generic GH Product"

Endotoxins (lipopolysaccharides, LPS) are major contaminants found in commercially available proteins or biologically active substances. LPS are highly potent immune stimulators able to cause side effects

Purification very often represents the most time consuming and cost intensive step of the whole production process. Therefore optimization of the downstream process is essential in order to achieve time and cost efficiency (3). Generally, high LPS concentrations can be reduced to about 100 EU/mL without special treatment, but many applications require an even lower-limit value as described within the pharmacopoeia — e.g., 5 endotoxin units (1 EU ≈ 100 pg) per kilogram of body weight per hour for intravenous applications.

Endotoxin Testing Analysis and Removal - Bio-Synthesis, Inc.

Bacteria pyrogen such as endotoxins, also called lipopolysaccharides (LPS), are major contaminants found in commercially available proteins or biologically active substances. This bacterial endotoxin is a potent stimulator of the mammalian immune system in vivo, and it may decrease tissue culture cell viability and inhibit transfection efficiency in vitro.

Also, bacterial residue in low grade Somatropin or Somatrem (192) can cause reactions

(I agree with jano that 192 is no longer common on the black market)

Painful red welts on injection spot can be caused by low quality growth hormone which contain too much bacterial residue (Endotoxins ((lipopolysaccharides, LPS)). This can lead to serious problems where the body could eventually develop resistance (Protein Immunogenicity) even against its own naturally produced growth hormone. (Immune response similar to Somatrem)
If the welts appear after every injection and persist for a day or two, then you should discontinue use

Injecting IM (BroScience) to elimate the reaction isn't best IMO

BC of Pharmas E-coli cloning process the release of endotoxins has become a non-issue, now whether thats the case for GGH IDK, but since the types of reactions being reported are localized to the injection site a more simplistic foreign protein etiology seems more likely, BUT considering the size of the innoculum is quite small, its difficult to say for sure.

 

[janoshik]

...

It's always valuable when you post! Thank you

 

[janoshik]

BC of Pharmas E-coli cloning process the release of endotoxins has become a non-issue, now whether thats the case for GGH IDK, but since the types of reactions being reported are localized to the injection site a more simplistic foreign protein etiology seems more likely, BUT considering the size of the innoculum is quite small, its difficult to say for sure.

What do you mean by cloning process and release of endotoxins being a non issue?

It's a part of the membrane of E. Coli (and other G- bacteria) and as the process is directly involving them there's always a risk of contamination.

Endotoxin is also a strong local immunogen, therefore it would cause strong localized response.

What exactly do you mean by more simplistic protein etiology? Is there some other immunogen as potent as endotoxin in the mix? Not to my knowledge. Therefore Occams razor dictates it's most probably that - but as you say, we can't tell for sure.

 

[Senorman]

Try shooting IM and make sure ur using bac water that is not expired

I've done IM (unexpired bac water) with hygetropin. Instead of a welt on the surface, my muscle was sore at injection site.....similar to PIP with test. Doesn't help the problem.