Phreezer said:
Where do you come up with this stuff? "Drinking it will be harder on the liver if you use it more than 6 weeks"???????????
Nope, not true at all. It effects your liver the same either way. No difference what so ever. The liver filters the blood. Whether the winstrol is injected or swallowed it makes it to the blood stream.
The difference between oral and injectable is nothing what so ever other than you need to take about 30% more roughly oraly over injection because about 30% of the dosage can not survive the digestive tract. You lose a little less than a 3rd of the dosage to your stomach acid and digestive enzymes.
Van-Man.. If you don't know something.. DON'T ANSWER IT.. Stop making shit up.
Some of your advice is now starting to border on harmful to the other members. If this guy were to take your advice he would be under the impression that injectable is safer possibly damaging his liver...
Now, I'm not going to warn you again about pulling answers out of your ass.. yesterday was the guy asking about abcess and you told him he could have tore the membrane around the muscle and some of the steroids could have leaked into the fat causing the lump and symptoms he was having. Saying that an IM injection will leak into the fat after an injection and cause inflamation or a possible abcess is just total horse shit
Stop spreading your logic as fact.. it's wrong and it's dangerous.. next time you do it I will give you a 48 hour vacation from Meso to think about what you post.
Have a nice day,
P
hang on....
As a general precautionary rule it is widely understood that oral use should be limited to no more than 6 weeks.
Orals are much harsher on the liver because of the concentration and time in which they reach the organ. Injectables are less potent by the time they reach the liver and arrive at a slower, more steady pace. I didn't make it up! I learned about it right here at Meso!
Taken from this website asshole! IF it is soooo fucking untrue then maybe you shouldn't allow members such as myself to be misinformed!
Winstrol - Oral vs. injectable:
First pass metabolism can occur in both the gut and the liver, and where this happens can vary with different drugs. First pass metabolism actually occurs in your gut for some drugs and in the liver for others. Once it has been metabolized, it enters the bloodstream. It’s important to note that when a blood is metabolized in the Gastrointestinal tract, the blood leaving the Gastrointestinal tract does not go right to the heart, but actually still passes through liver via the hepatic portal vein and then ultimately returns to circulation via the hepatic vein. The liver is your body’s filtration unit, and removes large quantities of nutrients, dangerous toxins (or fun toxins, depending on what they are) and other substances from the blood.
So as you can see, when you take an oral steroid such as Winstrol, undergoes a first-pass metabolism in the both the intestines as well as liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity, while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug then circulates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the liver again, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of Winstrol, an injectable version is available, and when we compare the oral and injectable versions of Winstrol and their effects in your body, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and only undergoes the far less extensive second pass metabolism, while the oral must endure the gut and liver on it’s first pass before ending up in circulation.
Now, here’s the interesting part: When you inject Winstrol, instead of taking it orally, you actually get more nitrogen retention (4) (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use Winstrol to build new muscle tissue, the injectable version is going to be far superior to the Oral version. However, there are some advantages that the oral version has over the injectable, including a possible “synergy” with other drugs- but only (primarily) when taken orally.
While in the liver, on it’s first pass, Winstrol is exposed to a variety of enzymes and proteins. To understand how a possible synergy between Winstrol and other steroids may be possible, a little background on Sex Hormone Binding Globulin (SHBG) is first necessary. For our purposes here, all we need to know is that SHBG is a glycoprotein produced in the liver, which binds to testosterone and makes it biologically unavailable to do all the things we want it to do- like building muscle. It serves to transport testosterone throughout the body, but while it remains bound to testosterone, the testosterone can not exert it’s anabolic effects.
