How long for HGH and IGF-1 to Return to Baseline?

[hungryalways]

Does anyone know how long it takes for endogenous HGH and IGF-1 to return to baseline after stopping rHGH?

I'm planning on stopping for a couple of weeks while I see a hematologist and thought it might be a good time to get baseline IGF-1 measured as I've never checked it off/on rHGH.

 

[songsofpyramids]

3 months for a full washout as I recall.

 

[crtx]

6 weeks. to peak 6 weeks to baseline.

 

[sinistral]

6 weeks vs 12 weeks is quite a difference. Is there any consensus on this?
I'd like to drop HGH as well but instead to get a baseline thyroid panel.

 

[Benf15harp]

I think it’s about 2 to 3 days

 

[Benf15harp]

Suppression and recovery of GH secretion after GH injection in non-GH deficient short children - PubMed

After 6 months of a thrice weekly GH treatment regimen in non-GH deficient short children, endogenous GH secretion was reduced from 24 to 36 h after injection compared to placebo and returned to control levels by 48 to 60 h after injection.

pubmed.ncbi.nlm.nih.gov

 

[sinistral]

Suppression and recovery of GH secretion after GH injection in non-GH deficient short children - PubMed

After 6 months of a thrice weekly GH treatment regimen in non-GH deficient short children, endogenous GH secretion was reduced from 24 to 36 h after injection compared to placebo and returned to control levels by 48 to 60 h after injection.

pubmed.ncbi.nlm.nih.gov

Ok thanks, I thought you were joking- according to this GH returns to baseline 2-3 days.

 

[songsofpyramids]

I think it’s about 2 to 3 days

Your gh goes to baseline quick but your igf1 does not. I know coaches like Type-IIX suggest waiting 3 months after last pin of hgh or ghrp/ghrh for igf1 to return to full baseline for testing purposes.

Ok thanks, I thought you were joking- according to this GH returns to baseline 2-3 days.

This only answers half of your question. You are very likely not getting a gh serum test but an igf1 test and that will be high for up to 12 weeks after discontinuing hgh.

 

[sinistral]

Your gh goes to baseline quick but your igf1 does not. I know coaches like Type-IIX suggest waiting 3 months after last pin of hgh or ghrp/ghrh for igf1 to return to full baseline for testing purposes.

This only answers half of your question. You are very likely not getting a gh serum test but an igf1 test and that will be high for up to 12 weeks after discontinuing hgh.

Understood. After that exchange I realized my question was more complex than just "when does GH return to baseline?" and decided to dig a bit deeper.
I've been going down that rabbit hole of what is actually impacting the thyroid and the T4-T3 conversion rate? Is it GH? Is it IGF-1? Or some other aspect of GH?

But in the end I came to your conclusion as well. I'll go with the 3 month wait to be sure. Thanks for the clarification.

 

[lilchikin]

Your gh goes to baseline quick but your igf1 does not. I know coaches like Type-IIX suggest waiting 3 months after last pin of hgh or ghrp/ghrh for igf1 to return to full baseline for testing purposes.



This only answers half of your question. You are very likely not getting a gh serum test but an igf1 test and that will be high for up to 12 weeks after discontinuing hgh.

By what mechanism does igf1 stay elevated for so long?

 

[songsofpyramids]

Is it GH? Is it IGF-1?

Cursory reading suggests gh itself is the driving force for thyroid change and igf-1 boosts it.

By what mechanism does igf1 stay elevated for so long?

I’m unsure what the exact mechanisms are but it makes sense to me as you want to wait 6 or more weeks when you reach your desired dose of hgh for igf-1 to raise before testing because it takes that long to become fully active on that angle of effect. Gh serum, on the other hand, will be giving you benefits from your first pin.

 

[AlexDavis43]

By what mechanism does igf1 stay elevated for so long?

Gene expression programming. Some bounce back faster than others.

 

[UncleBuns]

Thread 'Guide: How to Establish your Base-Line IGF-I (Serum) in Order to Determine Dose/Response (ΔIGF-I) to Agents that Increase IGF-I (e.g., rhGH)'

Oct 5, 2023

Establishing a Base-Line Serum IGF-I Value
Author: Type-IIx

Intent: (1) To help users establish a base-line serum IGF-I value In order to form a meaningful basis for comparison of serum IGF-I changes to base-line. (2) To help prospective clients (i.e., Comprehensive Coaching [training + nutrition + PEDs + supplements], or Individualized Protocols [PEDs + supplements]) have this data ready even before intake, so that we can get straight to the work of determining their drug response and forego superfluous periods of management of wash-out from agents that affect IGF-I levels...

• Type-IIx
• Replies: 3
• Forum: Serum Blood Testing

• 
• 

 

[songsofpyramids]

Thread 'Guide: How to Establish your Base-Line IGF-I (Serum) in Order to Determine Dose/Response (ΔIGF-I) to Agents that Increase IGF-I (e.g., rhGH)'

Oct 5, 2023

Establishing a Base-Line Serum IGF-I Value
Author: Type-IIx

Intent: (1) To help users establish a base-line serum IGF-I value In order to form a meaningful basis for comparison of serum IGF-I changes to base-line. (2) To help prospective clients (i.e., Comprehensive Coaching [training + nutrition + PEDs + supplements], or Individualized Protocols [PEDs + supplements]) have this data ready even before intake, so that we can get straight to the work of determining their drug response and forego superfluous periods of management of wash-out from agents that affect IGF-I levels...

• Type-IIx
• Replies: 3
• Forum: Serum Blood Testing

• 
• 

Was looking for this to share

 

[hungryalways]

Interested related topic. How long does LP(a) take to return to baseline after running HGH: Lipoprotein(a) / LP(a): Elevated From HGH (During & After?)