How long for HGH and IGF-1 to Return to Baseline?

[hungryalways]

Does anyone know how long it takes for endogenous HGH and IGF-1 to return to baseline after stopping rHGH?

I'm planning on stopping for a couple of weeks while I see a hematologist and thought it might be a good time to get baseline IGF-1 measured as I've never checked it off/on rHGH.

 

[songsofpyramids]

3 months for a full washout as I recall.

 

[crtx]

6 weeks. to peak 6 weeks to baseline.

 

[sinistral]

6 weeks vs 12 weeks is quite a difference. Is there any consensus on this?
I'd like to drop HGH as well but instead to get a baseline thyroid panel.

 

[Benf15harp]

I think it’s about 2 to 3 days

 

[Benf15harp]

Suppression and recovery of GH secretion after GH injection in non-GH deficient short children - PubMed

After 6 months of a thrice weekly GH treatment regimen in non-GH deficient short children, endogenous GH secretion was reduced from 24 to 36 h after injection compared to placebo and returned to control levels by 48 to 60 h after injection.

pubmed.ncbi.nlm.nih.gov

 

[sinistral]

Suppression and recovery of GH secretion after GH injection in non-GH deficient short children - PubMed

After 6 months of a thrice weekly GH treatment regimen in non-GH deficient short children, endogenous GH secretion was reduced from 24 to 36 h after injection compared to placebo and returned to control levels by 48 to 60 h after injection.

pubmed.ncbi.nlm.nih.gov

Ok thanks, I thought you were joking- according to this GH returns to baseline 2-3 days.

 

[songsofpyramids]

I think it’s about 2 to 3 days

Your gh goes to baseline quick but your igf1 does not. I know coaches like Type-IIX suggest waiting 3 months after last pin of hgh or ghrp/ghrh for igf1 to return to full baseline for testing purposes.

Ok thanks, I thought you were joking- according to this GH returns to baseline 2-3 days.

This only answers half of your question. You are very likely not getting a gh serum test but an igf1 test and that will be high for up to 12 weeks after discontinuing hgh.

 

[sinistral]

Your gh goes to baseline quick but your igf1 does not. I know coaches like Type-IIX suggest waiting 3 months after last pin of hgh or ghrp/ghrh for igf1 to return to full baseline for testing purposes.

This only answers half of your question. You are very likely not getting a gh serum test but an igf1 test and that will be high for up to 12 weeks after discontinuing hgh.

Understood. After that exchange I realized my question was more complex than just "when does GH return to baseline?" and decided to dig a bit deeper.
I've been going down that rabbit hole of what is actually impacting the thyroid and the T4-T3 conversion rate? Is it GH? Is it IGF-1? Or some other aspect of GH?

But in the end I came to your conclusion as well. I'll go with the 3 month wait to be sure. Thanks for the clarification.