A high enough dose can absolutely overcome GH resistance and increase IGF.
As BF % goes down suppressing IGF is the body’s way of pushing back against using nutrients for growth, reserving them strictly for fuel.
Exogenous Leptin would be very effective, it’s like a “SuperGLP” that cuts appetite, melts fat, boosts muscle growth, fewer side effects than GLP, but at the standard daily 10mg dose a little cost prohibitive lol
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This is something China UGL should be producing. It’d be a bigger seller than rHGH.