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I am on Mirapex (Prami): when do libido benefits kick in?

T

Tyler81

New Member
Hey all,

My doctor prescribed me Mirapex (Prami) both for depression and libido.

I was told to implement the following taper:

1/4 tablet am and pm ... when side effects are tolerable:
1/2 tablet am and pm .... when side effects are tolerable:
1 tablet am and pm... (this is max dose)

"If you achieve libido at lower doses, stay at the lower dose" (as per my doctor)



I started on Saturday with 1/4 tablet am and pm.

So far the daytime sleepiness is very bad. I literally need to pass out shortly after the morning dose.

Does this go away?

No noticeable libido benefits yet. I have noticed a few spontaneous errections but no change in desire.

I plan to increase to 1/2tablet am and pm tomorrow. I want to stay at this dose (and hope libido will kick in at this dose)


I am currently off testosterone.

I want to see if my natty levels + mirapex can give me a decent libido!

Thoughts and comments appreciated! :cool:
 
If testosterone increased your libido its going to be difficult achieving the same results with pharmaceuticals for a lifetime.
 
1erCru said:
If testosterone increased your libido its going to be difficult achieving the same results with pharmaceuticals for a lifetime.
Click to expand...

Not planning to do it for a lifetime man.

The issue for me is, testosterone makes me feel depressed. Not sure why. But it does.
 
You need to think about not what mirapex (pramipexole) will do for you, but instead, what it will do to you, and what the recovery is like when you want to get off.

Let me start by saying that you need to specify milligram amounts, not tablet equivalents, first and foremost.

Second, pramipexole does indeed increase libido in many subjects, but when you get off of it, and get off you will, your dopamine receptors will be down-regulated, and there consequences to that.

Your experience may differ than mine, but I've spent the last week off of pramipexole for the first time in 4 months, after having taken a dosage of 0.5 mg/day once daily. I've experienced depression, listlessness, mood swings, and social isolation since getting off. These effects were so pronounced that I saw my primary care doctor, yesterday, who prescribed bupropion (Wellbutrin) for me. Bupropion acts as a dopamine and norepinephrine reuptake inhibitor, prolonging the presence of dopamine and norepinephrine in the synaptic cleft. Pramipexole is a dopamine agonist (of a number of D#/x receptors), functionally increasing dopaminergic neuron activity.

The point of the last paragraph is to show you, mechanistically, what's occurring in your body when you take pramipexole, and why that can potentially be a problem. You see, down-regulation of neurons, a.k.a. "tolerance," can take a long time to correct. You might find yourself with symptoms similar to mine once you get off, and it's not pleasant. In fact, I wish that I'd never used pramipexole in the first place.

I would only consider using pramipexole if my prolactin was uncontrollable through other means.
 
Hmm thanks for the warning man...

I have reservations about Prami for sure. I have read all the horror stories on it.

Why did you get on prami in the first place?


So far i haven't even experienced any libido benefits (just extreme daytime drowysiness and fatigue) so i doubt i'll stay on this longterm anyway. I was am just curious to see what it can do with regards to libido/desire.

Each tablet is .5mg btw.

SacToSD said:
You need to think about not what mirapex (pramipexole) will do for you, but instead, what it will do to you, and what the recovery is like when you want to get off.

Let me start by saying that you need to specify milligram amounts, not tablet equivalents, first and foremost.

Second, pramipexole does indeed increase libido in many subjects, but when you get off of it, and get off you will, your dopamine receptors will be down-regulated, and there consequences to that.

Your experience may differ than mine, but I've spent the last week off of pramipexole for the first time in 4 months, after having taken a dosage of 0.5 mg/day once daily. I've experienced depression, listlessness, mood swings, and social isolation since getting off. These effects were so pronounced that I saw my primary care doctor, yesterday, who prescribed bupropion (Wellbutrin) for me. Bupropion acts as a dopamine and norepinephrine reuptake inhibitor, prolonging the presence of dopamine and norepinephrine in the synaptic cleft. Pramipexole is a dopamine agonist (of a number of D#/x receptors), functionally increasing dopaminergic neuron activity.

The point of the last paragraph is to show you, mechanistically, what's occurring in your body when you take pramipexole, and why that can potentially be a problem. You see, down-regulation of neurons, a.k.a. "tolerance," can take a long time to correct. You might find yourself with symptoms similar to mine once you get off, and it's not pleasant. In fact, I wish that I'd never used pramipexole in the first place.

I would only consider using pramipexole if my prolactin was uncontrollable through other means.
Click to expand...
 
Tyler81 said:
Hmm thanks for the warning man...

I have reservations about Prami for sure. I have read all the horror stories on it.

Why did you get on prami in the first place?


So far i haven't even experienced any libido benefits (just extreme daytime drowysiness and fatigue) so i doubt i'll stay on this longterm anyway. I was am just curious to see what it can do with regards to libido/desire.

Each tablet is .5mg btw.
Click to expand...

I got on pramipexole to combat low libido and high prolactin, caused by use of trenbolone. While there are mixed opinions on trenbolone and its effects, people seem to universally have increased prolactin from trenbolone (and nandrolone) use, and the adverse effects of increased prolactin oftentimes correct when prolactin is lowered.

So I ask, what's your prolactin level? Mine is 15 ng/dL on a reference range of 4-15. Further, my estrogen level is 48.9 pg/mL on a reference range of 7.6-42.6. I've heard that with a prolactin above ~8 causes libido suppression and erectile difficulties. Do you have an estrogen, too?
 
SacToSD said:
I got on pramipexole to combat low libido and high prolactin, caused by use of trenbolone. While there are mixed opinions on trenbolone and its effects, people seem to universally have increased prolactin from trenbolone (and nandrolone) use, and the adverse effects of increased prolactin oftentimes correct when prolactin is lowered.

So I ask, what's your prolactin level? Mine is 15 ng/dL on a reference range of 4-15. Further, my estrogen level is 48.9 pg/mL on a reference range of 7.6-42.6. I've heard that with a prolactin above ~8 causes libido suppression and erectile difficulties. Do you have an estrogen, too?
Click to expand...

My prolactin is actually okay....

Estrogen flucuates but i dont feel much different with low, medium or high estrogen. So I think estrogen is overrated. Or at least i'm not that sensitive to it unless its extremely high.

I will give this a week (just to see what the desire/libido is like) and then i'll probably call it quits.

*If* it gives me a crazy ridiculous hypersexuality type libido i *may* stay with it for a little bit longer ;) :cool:
 
SacToSD said:
You need to think about not what mirapex (pramipexole) will do for you, but instead, what it will do to you, and what the recovery is like when you want to get off.

Let me start by saying that you need to specify milligram amounts, not tablet equivalents, first and foremost.

Second, pramipexole does indeed increase libido in many subjects, but when you get off of it, and get off you will, your dopamine receptors will be down-regulated, and there consequences to that.

Your experience may differ than mine, but I've spent the last week off of pramipexole for the first time in 4 months, after having taken a dosage of 0.5 mg/day once daily. I've experienced depression, listlessness, mood swings, and social isolation since getting off. These effects were so pronounced that I saw my primary care doctor, yesterday, who prescribed bupropion (Wellbutrin) for me. Bupropion acts as a dopamine and norepinephrine reuptake inhibitor, prolonging the presence of dopamine and norepinephrine in the synaptic cleft. Pramipexole is a dopamine agonist (of a number of D#/x receptors), functionally increasing dopaminergic neuron activity.

The point of the last paragraph is to show you, mechanistically, what's occurring in your body when you take pramipexole, and why that can potentially be a problem. You see, down-regulation of neurons, a.k.a. "tolerance," can take a long time to correct. You might find yourself with symptoms similar to mine once you get off, and it's not pleasant. In fact, I wish that I'd never used pramipexole in the first place.

I would only consider using pramipexole if my prolactin was uncontrollable through other means.
Click to expand...

I'll second this. Do a search on Dopamine Agonist Withdrawal Syndrome.

This thread on M&M is full of good info on it. This guy was dealing with it for over a year IIRC.

DAWS (Dopamine Agonist Withdrawal Syndrome) - Mind And Muscle Forum
 
CubbieBlue said:
I'll second this. Do a search on Dopamine Agonist Withdrawal Syndrome.

This thread on M&M is full of good info on it. This guy was dealing with it for over a year IIRC.

DAWS (Dopamine Agonist Withdrawal Syndrome) - Mind And Muscle Forum
Click to expand...


Thanks for the heads up.

Yeah man I have read about mirapex on M&M forum... i think that dude who had one year withdrawal was atypical.

But i am definetly aware of the risks of this med. I just want to see what it can do. If it sucks in terms of libido, then cool. I'm done with it. If it's awesome, i will have to decide if i want to take it longterm or not.


Right now I am just seeing what it can do.
 
Wait a minute, wait a minute....

Tyler, you claimed repeateldy that your libido is raging and that TRT has solved your problems. You allegedly masturbate often.

What gives?

Secondly, I sincerely doubt that your doctor prescribed you a Parkinson's medication for libido and depression. You aren't anywhere near the state where'd you require dipping into that sort of territory. Furthermore, it does not even increase libido. That's a rare side effect.
 
Tyler81 said:
My prolactin is actually okay....

Estrogen flucuates but i dont feel much different with low, medium or high estrogen. So I think estrogen is overrated. Or at least i'm not that sensitive to it unless its extremely high.

I will give this a week (just to see what the desire/libido is like) and then i'll probably call it quits.

*If* it gives me a crazy ridiculous hypersexuality type libido i *may* stay with it for a little bit longer ;) :cool:
Click to expand...

Welcome to my world. No one knows exactly what the long term effects of trenbolone are, and if they correct, at all. They also don't know what causes the side effects of trenbolone. I'm in the middle of manipulating my estrogen and prolactin, trying to see what works, for me. Like I said, with the pramipexole, the risks outweigh the benefits in most people's cases. More of us on this board need to do research (academic). I'm determined to solve my problem, and not give up. If it helps you, good.
 
Most report that the sleppiness passes in a few days to weeks. There seems to be wide variations in the effects in different people.
I find it hard to understand how T makes you worse. :confused:
 
Wtf? Didnt you just create a thread like 2 wees ago espousing the benefits of a new ssri you had just started?!?! What the hell man? seems to me you are just experimenting with things for short intervals? None of my busines really you do whatever you want I just find it bizarre how you were telling everyone not to "knock ssris" now it seemds youve even givven up on that and are on to something else...in 2 weeks. interesting.
 
James23 said:
Wait a minute, wait a minute....

Tyler, you claimed repeateldy that your libido is raging and that TRT has solved your problems. You allegedly masturbate often.

What gives?

Secondly, I sincerely doubt that your doctor prescribed you a Parkinson's medication for libido and depression. You aren't anywhere near the state where'd you require dipping into that sort of territory. Furthermore, it does not even increase libido. That's a rare side effect.
Click to expand...


It's complicated.

I had to come off wellbutrin because it wasnt working @ 300mg per day and that dose was already giving me anxiety so there was no way i was gonna raise it to 450mg per day. When I came off wellbutrin I started to feel depressed on testosterone alone.... so I decided to come off testosterone.

I was prescribed Prami after expressing concern over my low libido. It also has applications in treatment resistant depression.

Also, i never said "i masturbate often" so i have no idea where you got that from :confused:
 
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