[OA] Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling
Highlights
· Exercise reduces visceral adipose tissue mass
· Loss of visceral adipose tissue mass following exercise is dependent on IL-6
· IL-6 receptor blockade increases total cholesterol and is not influenced by exercise
· Improvements in cardiorespiratory fitness following exercise are not IL-6 dependent
Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6.
In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise.
Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.
[OA] Wedell-Neergaard A-S, Lang Lehrskov L, Christensen RH, et al. Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial. Cell Metabolism. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30744-7
Highlights
· Exercise reduces visceral adipose tissue mass
· Loss of visceral adipose tissue mass following exercise is dependent on IL-6
· IL-6 receptor blockade increases total cholesterol and is not influenced by exercise
· Improvements in cardiorespiratory fitness following exercise are not IL-6 dependent
Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6.
In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise.
Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.
[OA] Wedell-Neergaard A-S, Lang Lehrskov L, Christensen RH, et al. Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial. Cell Metabolism. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30744-7
