I think what your trying to put together is a Plan to , not get "Gyno" "And you ask about your nuts??? Mister "High E 2 is not happy at the moment. And to answer your question, Yes, E2 can lead to all kinds of "manageable" side's <<<Key word, ...The only way to control Prolactin, Progesterone + "Gynecomastia" !! Easy.. "Control your "Estrogens". Yes sir, it's that easy So, for me {or the community } to help you, give us "weight", all {wk} totalllll.. Of each compound.. "must." Serms/Ai's /total mg's and any "Lab" work would be a ++++. Don't be afraid to ask for help. I got ya bro. I 'll give you a plan...Long term..........AnalogMan