Bro, just because you can't feel the difference yourself or your opinion is that others can't doesn't mean it isn't possible.
You do realize that 25 E2 is in normal range and 55 is above normal range.
Absolutely people can feel the difference between being in range and being above range.
They should go off of bloods and not feels but your statement that someone else you don't know can't feel the difference is naive at best.
@Georgetrenson, letro absolutely does make sense for some people. Different people will react differently to the same drug. Bottom line, check bloods and use the drug that works best for YOU.