I'm asking because it feels like 1/2 says they can run high test with some tren without any problems and the other 1/2 says tren should only be run with low test because the excess test that’s just flowing around in your bloodstream is going to cause E2 issues.
I got itchy nipples on 250/250 Test/Tren but on 300 Test only I've never had E2 issues so maybe there’s some truth to it?
I think the whole low test with tren idea came in because prolactin from 19 nors is directly influenced by higher estrogen levels, such that high estrogen can make prolactin higher, and then of course you get the high e2 + high prolactin sides plus maybe some gyno formation.
As for the whole receptor binding topic--its true that the body only has so many andorgenic receptors to bind to, but I doubt you're pushing gear dosages where this would even be a concern, nor could I tell you what this threshold would be where you'd cap out at x test, x tren, with only diminishing returns in increasing the dose.
What i will say is that i like low test (250-375l and moderate tren when cutting, just to stay dryer and not have to worry about e2 or prolactin control as much. I also don't have to worry about muscle loss on a high protein diet with tren (the most powerful anticatabolic aas) in the mix
And bulking I'll do 500-750 test and slightly lower tren, and then I'll just make sure I'm ontop of my e2 control.
Never really get prolactin issues as long as i control e2. Sometimes I'll need a caber, but not often
