looking for Abilify

[notanothersnake]

Or worse, I have heard it causes fuck heads to start scamming

Well fuck that!

 

[notanothersnake]

Yeah the only reason I considered the idea is a friend of mine who has used a lot of anti depressive type meds under a dr care is loving it. My wife "prescribed herself" prozac, I dislike it because it makes her an alien who doesnt care about anything. At first glance, abilify seemed like a middle of the road med. Evidently not so much lol.

I'm dropping adrol and dbol (both were lowered dosed) from my cycle. Hoping to feel better. It's almost like the last time I ran EQ real high...made me real paranoid.

 

[Havah]

This. If anything it will make you tired as fuck, and unable to excel in physical activity.

For most patients abilify wont have any sedative effect if prescribed at a reasonnable dosage

Ok the contrary its been actually sold for its "activating" effect which imo is a lot of bulshit

 

[Havah]

No, go on. This thread was finished as soon as it started. What other agents would you resort to before prescribing Abilify, and what are your reasons?

Ill write that down tomorow as im on the phone atm and this is gonna be a long one : P

 

[Burrr]

I like the suggestion about smoking a joint. Will have you get your calories too.
I've heard that dbol is known for having a pretty positive attitude as a side effect.
Tanking your estrogen on the other hand it's notorious for making you feel like shit

 

[The Terminator]

Horrible idea. SSRI medications- especially with the shit abilify has in it- are NOT pick me ups. Smoke a fucking joint. Shoot some heroin if that doesn't work. Taking meds like that because your cycle has you depressed? Find a new hobby.

Crystallized methamphetamine would would be superior to heroin for his goals.

 

[brutus79]

Yeah, but a powerlifter with tardive dyskinesia would be fun to watch. Lol

Buddy! How the hell are ya?

 

[Thaistick]

A psychiatrist put me on abilify once about 9 years ago Shit was awful It had me crying hysterically for no reason No antidepressants or antipsychotics for me thanks.

 

[pharmacist]

@brutus79 , @CensoredBoardsSuck whats up guys?
That should be the thread of the month Both of you in the same day in same thread

 

[Skorecese]

Please dont take abilify I was put on in high school when I was constantly getting into fights and getting arrested and it really fucked me up

 

[Havah]

No, go on. This thread was finished as soon as it started. What other agents would you resort to before prescribing Abilify, and what are your reasons?

alright so briefly:

- the first obvious issue with aripiprazol is its poor - if any - efficacity in bipolar depression, which could very well account for as much as 50% of the people going through a depressive episode, that number could be even higher when faced with refractory MDD
that alone in some cases is just a no go to augment an ISSR with abilify

- treatment of choice for refractory depression is and will remain electroconvulsive therapy, with about 60% response rate it is BY FAR the best option at hand is still used way too late

- akathisia is a real issue with abilify and as opposed to other common psychotropes sides effects you need to have a patient with decent speed because its - unless very intense - very subjective
like i see someone sleeping for 15 hours a day i know theyre sedated ( bar depression hypersomnia ), i see somenoe putting on 20 lbs in 3 months i know theyre taking weight, akathisia is much harder to assess

- some patients with refractory depression also have a high suicide attempt rate and those will benefit lithium adjunction more just on the sole fact that lithium ( and clozapine ) has anti-suicide properties

- due to its dopamine agonist-antagonist properties, usage of abilify with other neuroleptics or dopamine agonists / antagonist is a bit of a gamble, and even tho loxapine and other sedative neuroleptiques ( which are often resorted to for refractory depression / dysthymia because of the tolerance effect of BZD ) have a low d2 potency, its still there and no one really knows how it interacts

- theres always a different between what studies come up and what actually works, esp in psychiatry
people on the field are sometimes dubious with abilify because damn, you cant just refute well done studies, but neither can you just disregard the common feeling that abilify doesnt work as good as the other neuroleptics
there is some weird stuff going on behind the scene with this one, i cannot fanthom how it got FDA approved for acute sedation or BP depression given how useless it is, im pretty sure we still havent heard the whole story with abilify


now dont get me wrong, bar akathisia its probably the most tolerated neuroleptic as far as sedation, libido ( can actually improves libido ), cardiac and sedation go and sometimes its the clear choice, but when its not i really rather resort to other meds before prescribing abilify
( the other meds are all within the starD study and more recent studies and none is more effective than the other in refractory depression so yea theres a pretty wide choice, tho again ECT has to be used rather sooner than later )

 

[Havah]

alright so briefly:

- the first obvious issue with aripiprazol is its poor - if any - efficacity in bipolar depression, which could very well account for as much as 50% of the people going through a depressive episode, that number could be even higher when faced with refractory MDD
that alone in some cases is just a no go to augment an ISSR with abilify

- treatment of choice for refractory depression is and will remain electroconvulsive therapy, with about 60% response rate it is BY FAR the best option at hand is still used way too late

- akathisia is a real issue with abilify and as opposed to other common psychotropes sides effects you need to have a patient with decent speech because its - unless very intense - very subjective
like i see someone sleeping for 15 hours a day i know theyre sedated ( bar depression hypersomnia ), i see somenoe putting on 20 lbs in 3 months i know theyre taking weight, akathisia is much harder to assess

- some patients with refractory depression also have a high suicide attempt rate and those will benefit lithium adjunction more just on the sole fact that lithium ( and clozapine ) has anti-suicide properties

- due to its dopamine agonist-antagonist properties, usage of abilify with other neuroleptics or dopamine agonists / antagonist is a bit of a gamble, and even tho loxapine and other sedative neuroleptiques ( which are often resorted to for refractory depression / dysthymia because of the tolerance effect of BZD ) have a low d2 potency, its still there and no one really knows how it interacts

- theres always a different between what studies come up and what actually works, esp in psychiatry
people on the field are sometimes dubious with abilify because damn, you cant just refute well done studies, but neither can you just disregard the common feeling that abilify doesnt work as good as the other neuroleptics
there is some weird stuff going on behind the scene with this one, i cannot fanthom how it got FDA approved for acute sedation or BP depression given how useless it is, im pretty sure we still havent heard the whole story with abilify


now dont get me wrong, bar akathisia its probably the most tolerated neuroleptic as far as sedation, libido ( can actually improves libido ), cardiac and sedation go and sometimes its the clear choice, but when its not i really rather resort to other meds before prescribing abilify
( the other meds are all within the starD study and more recent studies and none is more effective than the other in refractory depression so yea theres a pretty wide choice, tho again ECT has to be used rather sooner than later )

 

[CensoredBoardsSuck]

- the first obvious issue with aripiprazol is its poor - if any - efficacity in bipolar depression, which could very well account for as much as 50% of the people going through a depressive episode, that number could be even higher when faced with refractory MDD
that alone in some cases is just a no go to augment an ISSR with abilify

If your patient is in the depressive phase of bipolar disorder, your argument could just as easily apply to SSRI therapy itself. Bipolar depression is often severe and notoriously resistant to pharmacological intervention. This is one situation where I'm inclined to agree with you that ECT is usually appropriate.

- treatment of choice for refractory depression is and will remain electroconvulsive therapy, with about 60% response rate it is BY FAR the best option at hand is still used way too late

Good luck trying to convince a moderately depressed partial responder to agree to ECT. Why wouldn't you try simpler interventions like switching ADs, adding thyroid hormone, buproprion, buspirone, pindolol, etc - or God forbid, psychotherapy - before suggesting ECT?

- akathisia is a real issue with abilify and as opposed to other common psychotropes sides effects you need to have a patient with decent speed because its - unless v

Aripiprizole augmentation studies have found akathisia to be mild to moderate, occuring in less than 30% of participants, and over half of the akathisia events resolved at endpoint. Discontinuation due to akathisia is rare. The issue is overblown.

- some patients with refractory depression also have a high suicide attempt rate and those will benefit lithium adjunction more just on the sole fact that lithium ( and clozapine ) has anti-suicide properties

Suicidality is high in depression, period. That's not an argument for lithium augmentation per se. It is an argument for treating the depression as effectively as possible though.

- due to its dopamine agonist-antagonist properties, usage of abilify with other neuroleptics or dopamine agonists / antagonist is a bit of a gamble, and even tho loxapine and other sedative neuroleptiques ( which are often resorted to for refractory depression / dysthymia because of the tolerance effect of BZD ) have a low d2 potency, its still there and no one really knows how it interacts

No one knows how any of these drugs work. It's an educated guess, at best.

- theres always a different between what studies come up and what actually works, esp in psychiatry
people on the field are sometimes dubious with abilify because damn, you cant just refute well done studies, but neither can you just disregard the common feeling that abilify doesnt work as good as neuroleptics

"The common feeling that Abilify just doesn't work as good" sounds like bias. It's certainly not evidence based medicine.

Psychopharmacology is often as much art as science, and it takes a lot of trial and error to get good at it. Following the evidence helps. Discounting it usually doesn't.

 

[Havah]

If your patient is in the depressive phase of bipolar disorder, your argument could just as easily apply to SSRI therapy itself. Bipolar depression is often severe and notoriously resistant to pharmacological intervention. This is one situation where I'm inclined to agree with you that ECT is usually appropriate.



Good luck trying to convince a moderately depressed partial responder to agree to ECT. Why wouldn't you try simpler interventions like switching ADs, adding thyroid hormone, buproprion, buspirone, pindolol, etc - or God forbid, psychotherapy - before suggesting ECT?



Aripiprizole augmentation studies have found akathisia to be mild to moderate, occuring in less than 30% of participants, and over half of the akathisia events resolved at endpoint. Discontinuation due to akathisia is rare. The issue is overblown.



Suicidality is high in depression, period. That's not an argument for lithium augmentation per se. It is an argument for treating the depression as effectively as possible though.



No one knows how any of these drugs work. It's an educated guess, at best.



"The common feeling that Abilify just doesn't work as good" sounds like bias. It's certainly not evidence based medicine.

Psychopharmacology is often as much art as science, and it takes a lot of trial and error to get good at it. Following the evidence helps. Discounting it usually doesn't.

Hey

Maybe i wasnt clear abour bipolar depression, what i meant is there are a LOT of patients that go through MDDs for years and recieve agents that have no efficacy on bipolar depression only to realise 5 years later they were bipolar
My point is if im gonna augment, why not augment with something also useful on bipolar depression? Might aswell


I didnt discuss about the other augmentation options as i m sure we both know them, point was why amongst those options i m not considering abilify as a first line options

I m always assuming patients are both under medication AND psychotherapy , i see no reason not to, i dont really think it can be called an augmentation strategy as it should be pretty much baseline

We have the same number in mind and 30% is a whole lot

The point about ECT is it is much like clozapine always used too late and should be used much earlier in refractory MDD than it currently is, and to answer you yes convicing a depressive patient about anything, is always challenging, but i can be very persuasive

The stand on lithium is currently a bit more complex so far as keeping a low dose lithium for patients with high risk of suicide is being considered, point was appart from low side effects abilify doesnt bring much

I m disapointed you quoted one sentence of my answer about studies and abilify tbh.
Evidence based also has its limits and i just think the abilify case could be one of them
I m still using it, im just a bit more dubious about it

 

[eryximachus]

I have a friend that just got put on it and its working great for him.

I normally don't need this kinda thing but im running a heavy cycle for a PL meet and just need a bump in my mood.

I have items to trade if anyone is interested...

Seroquel is probably better as it has the strongest anxiolytic effects out of all the atypical antipsychotics.

For short term use, I think it is a good choice. The dosage flexibility is awesome. You can start at 50mg to help you sleep, or go up to 300-600 to control your mood while on say, a high dose of tren. You can use it during PCT to help with anxiety as well. Basically, for all the reasons bros end up on benzos, Seroquel works.

Also, it is not a controlled substance and you can get it from places like ReliableRX for maybe $10-$20 per month.

 

[vitamin_S]

I have a friend that just got put on it and its working great for him.

I normally don't need this kinda thing but im running a heavy cycle for a PL meet and just need a bump in my mood.

I have items to trade if anyone is interested...

This is a horrible idea.See a doctor for that....

 

[The Terminator]

Seroquel is probably better as it has the strongest anxiolytic effects out of all the atypical antipsychotics.

For short term use, I think it is a good choice. The dosage flexibility is awesome. You can start at 50mg to help you sleep, or go up to 300-600 to control your mood while on say, a high dose of tren. You can use it during PCT to help with anxiety as well. Basically, for all the reasons bros end up on benzos, Seroquel works.

Also, it is not a controlled substance and you can get it from places like ReliableRX for maybe $10-$20 per month.

If you need an antipsychotic to use tren then what you really need is to not use tren. I’m kinda weird but haven’t noticed any psychological effects with tren, maybe a shorter fuse.

 

[Havah]

Seroquel is probably better as it has the strongest anxiolytic effects out of all the atypical antipsychotics.

For short term use, I think it is a good choice. The dosage flexibility is awesome. You can start at 50mg to help you sleep, or go up to 300-600 to control your mood while on say, a high dose of tren. You can use it during PCT to help with anxiety as well. Basically, for all the reasons bros end up on benzos, Seroquel works.

Also, it is not a controlled substance and you can get it from places like ReliableRX for maybe $10-$20 per month.

Friendly reminder seroquel needs an EKG upon traitement initiation, a bunch of bloodwork value, has a terrible metabolic impact and is one the most thrombogenic neuroleptic
Not even talking about libido issueq which are very common

What a terrible idea, lol

 

[janoshik]

Friendly reminder seroquel needs an EKG upon traitement initiation, a bunch of bloodwork value, has a terrible metabolic impact and is one the most thrombogenic neuroleptic
Not even talking about libido issueq which are very common

What a terrible idea, lol

This.

...and hard on liver.

 

[notanothersnake]

Just in case anyone cares, a few days now since I dropped the adrol and dbol hating life a whole lot less now lol. Wife still isnt doing what I think she should be doing everyday but that's normal lol.

Thanks for the replies. Sometimes people just need to be told what they already know they should do. And I knew what I was going to get when I opened this thread on this board.