lowest LDL without using a PCSK9 inhibitor?

[just some dude]

what’s the lowest you’ve managed to get your LDL without using a PCSK9 inhibitor?

 

[nullandvoid]

50 so far. Ordered some Bemp/Eze tablets and will be adding that in a few weeks (already on Pita and Eze). The Bemp/Eze combo tablets were just way cheaper than buying Bemp alone.

 

[Infernalmango]

47. 150mg trt/wk. 6g epa/dha a day was the biggest driver I believe.. I was also around 100g fats a day from quality sources - eggs/meat/olive oil.

 

[Burly]

4g epa/dha, cardio and 2.1 LDL
(no statin)

 

[Ghoul]

I’ve seen people get into the upper 20s, starting from 90-100, using a statin and ezetimibe, or statin+ezetimibe+bemp acid.

Ezetimibe is the main wildcard that can create a much bigger drop than expected. This is because the “transporter” that moves cholesterol from the gut into blood is present in some people at much higher levels than than others. Eze loads this transporter with “blank loads”, so they can’t carry cholesterol. For these folks the LDL drop can be huge.

 

[Ghoul]

4g epa/dha, cardio and 2.1 LDL
(no statin)

@nullandvoid That’s euro / uk nmol units not mg.

Equivalent to 81 LDL in numbers you’re used to

 

[deadbeef]

LDL = 34 on Nexlizet, Pitavastatin 4mg, Reta 12mg. ApoB = 43.

 

[Burly]

@nullandvoid That’s euro / uk nmol units not mg.

Equivalent to 81 LDL in numbers you’re used to

mmol/l Yes

 

[Ghoul]

I’ll just mention here if anyone in US does want Repatha, get a prescription from your doctor or telehealth, and get a coupon code from goodRx for your pharmacy.

Amgen lowered the price for cash payers from $700/mo to $239 (lowest in the world). If you DO go through your insurance policy get a “copay card” from Repatha.com and your price will be $15/mo with Repatha picking up the rest. If you’re uninsured, and your household income is less than 3x the poverty level (ie $50k for 1 person, higher for multiple), you can get Repatha for free.

They had been selling direct but decided to work through GoodRx instead.




As someone pointed out, even if you only use 1, instead of 2 pens a month, you’ll still get most of the benefit at half the cost.

Finally, this is the only way at the moment to put a big dent in Lp(a), dropping it by ~30%.

 

[nullandvoid]

Damn. With 2.1, I was thinking his arteries were going to be aging in reverse.

 

[tut]

I’ll just mention here if anyone in US does want Repatha, get a prescription from your doctor or telehealth, and get a coupon code from goodRx for your pharmacy.

Amgen lowered the price for cash payers from $700/mo to $239 (lowest in the world). If you DO go through your insurance policy get a “copay card” from Repatha.com and your price will be $15/mo with Repatha picking up the rest. If you’re uninsured, and your household income is less than 3x the poverty level (ie $50k for 1 person, higher for multiple), you can get Repatha for free.

They had been selling direct but decided to work through GoodRx instead.


View attachment 367312

As someone pointed out, even if you only use 1, instead of 2 pens a month, you’ll still get most of the benefit at half the cost.

Finally, this is the only way at the moment to put a big dent in Lp(a), dropping it by ~30%.

Thanks for the great info Ghoul, as always.

what is the process like for getting Repath prescription via telehealth (eg GoodRx or similar)? I could care less if my insurance will cover it (I will pay the $239/m if needed). I take Bemp + Eze combo & Pita 4mg - but not prescribed thru a provider (India Pharma)