legendary
Well-known Member
see that this drug is growing in popularity. Thought this was a good read.
Drostanolone is a DHT derivative that has quite a history in medicine. It was originally
use to treat Breast Cancer, but has fallen out of favor because of newer medications.
What a lot of people don't realize is that it is not only a mild AI but is also a potent SERM.
Thus the reason why it was used to treat Breast Cancer, because it competes with E2 for binding
at the receptor.
I have personally totally crashed my E2 on Masteron because of ignorance.
I have to take a daily dose of Cialis to keep my BPH in check. It keeps my urine stream from totally
blocking. My very first experience with Masteron was last month. To my amazement it blasted my
BPH symptoms down to where I actually had a quite strong urine stream.
Huh?
Here's the science: Prostate growth after maturity is contributed to by an "out of whack" T to E2 ratio.
As we men get older, we produce less T, E2 dominates. Thus the bellies, flabby muscles, etc.
Research has found that there is a SHBG relationship to prostate growth. The SHBG substrate binds with a receptor in the Prostate called R-shbg. When E2 binds with the SHBG/R-shbg site, is initiates
gene transcription in the Prostate leading to growth. There is also a metabolite of DHT, formerly thought to be inert, which in fact does the same thing when it binds to SHBG/R-shbg
5a-androstan-3a,17b-diol also known as simply 3a-diol.(1)
My own experiment with Drostanolone by no means establishes for a fact that it will work for everyone. It worked for me. That's all I care about. I am just sharing.
I absolutely refuse to take an androgen blocker. Cut my penis off first. DHT is the essence of
being male.
My hair follicles survived Chemotherapy for Leukemia, which fried my nuts, which led me to need TRT.
I will not be going bald any time soon from DHT. Not in my genes.
Not suggesting that anyone with BPH or Prostate issues run out and try Drostanolone. Discuss it with your doctor.
I defer to the knowledge of our good Dr. Crisler on this forum, as I would be most interested to see his take on this. My own GP, who is an exceptionally smart man, with 40 years of medical practice,
thought this article was very interesting. He has been battling with his more "conventional" colleagues about the role of PSA in diagnosing cancer, and he pointed out to them that Prostate Cancer cells do not and cannot produce PSA. So you could have a metastatic cancer and not know it, even with a low PSA.
Before anyone starts flaming me about DHT, remember that Drostanolone has a lower androgenic rating than Testosterone, whereas DHT has a much higher androgenic rating.
Just my tuppence
(1) Sex Hormone-Binding Globulin Mediates Prostate
Androgen Receptor Action via a Novel Signaling
Pathway
This was a copy and paste.
Drostanolone is a DHT derivative that has quite a history in medicine. It was originally
use to treat Breast Cancer, but has fallen out of favor because of newer medications.
What a lot of people don't realize is that it is not only a mild AI but is also a potent SERM.
Thus the reason why it was used to treat Breast Cancer, because it competes with E2 for binding
at the receptor.
I have personally totally crashed my E2 on Masteron because of ignorance.
I have to take a daily dose of Cialis to keep my BPH in check. It keeps my urine stream from totally
blocking. My very first experience with Masteron was last month. To my amazement it blasted my
BPH symptoms down to where I actually had a quite strong urine stream.
Huh?
Here's the science: Prostate growth after maturity is contributed to by an "out of whack" T to E2 ratio.
As we men get older, we produce less T, E2 dominates. Thus the bellies, flabby muscles, etc.
Research has found that there is a SHBG relationship to prostate growth. The SHBG substrate binds with a receptor in the Prostate called R-shbg. When E2 binds with the SHBG/R-shbg site, is initiates
gene transcription in the Prostate leading to growth. There is also a metabolite of DHT, formerly thought to be inert, which in fact does the same thing when it binds to SHBG/R-shbg
5a-androstan-3a,17b-diol also known as simply 3a-diol.(1)
My own experiment with Drostanolone by no means establishes for a fact that it will work for everyone. It worked for me. That's all I care about. I am just sharing.
I absolutely refuse to take an androgen blocker. Cut my penis off first. DHT is the essence of
being male.
My hair follicles survived Chemotherapy for Leukemia, which fried my nuts, which led me to need TRT.
I will not be going bald any time soon from DHT. Not in my genes.
Not suggesting that anyone with BPH or Prostate issues run out and try Drostanolone. Discuss it with your doctor.
I defer to the knowledge of our good Dr. Crisler on this forum, as I would be most interested to see his take on this. My own GP, who is an exceptionally smart man, with 40 years of medical practice,
thought this article was very interesting. He has been battling with his more "conventional" colleagues about the role of PSA in diagnosing cancer, and he pointed out to them that Prostate Cancer cells do not and cannot produce PSA. So you could have a metastatic cancer and not know it, even with a low PSA.
Before anyone starts flaming me about DHT, remember that Drostanolone has a lower androgenic rating than Testosterone, whereas DHT has a much higher androgenic rating.
Just my tuppence
(1) Sex Hormone-Binding Globulin Mediates Prostate
Androgen Receptor Action via a Novel Signaling
Pathway
This was a copy and paste.
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