Never had this side affect with mast, and i run it every cycle, and have run pretty high amounts when I was younger and more reckless about my cycles
but out of curiosity I did look up the terminology you referred to an found an excerpt that says "steroid use, especially long-term and high-dose usage, can be associated with the development of posterior subcapsular cataracts. Posterior subcapsular cataracts are a type of cataract that occurs on the back surface of the lens capsule within the eye. Steroids can cause cataracts by various mechanisms, including altering the metabolism of the lens proteins and promoting the accumulation of fluid within the lens, leading to clouding and opacification over time."
The development of cataracts, including posterior subcapsular cataracts, is a complex process influenced by various factors. When it comes to steroid-induced cataracts, several mechanisms have been proposed:
- Metabolic changes in lens proteins: Steroids can alter the metabolism of proteins within the lens of the eye. Normally, the lens proteins are maintained in a delicate balance of synthesis and degradation. Steroids can disrupt this balance, leading to the accumulation of abnormal proteins within the lens. These abnormal proteins can aggregate and contribute to the clouding and opacification characteristic of cataracts.
- Promotion of glycation: Steroids may promote glycation, a process where sugars attach to proteins, within the lens. This can lead to the formation of advanced glycation end products (AGEs), which can cause cross-linking of proteins and contribute to lens opacity.
- Disruption of ion transport: Steroids can affect ion transport mechanisms within the lens cells. Proper ion balance is crucial for maintaining lens transparency. Alterations in ion transport can lead to the accumulation of fluid within the lens, causing swelling and disruption of the lens structure, ultimately leading to cataract formation.
- Induction of oxidative stress: Steroids can increase the production of reactive oxygen species (ROS) within the lens cells. ROS are highly reactive molecules that can damage cellular components, including proteins and DNA. Oxidative stress plays a significant role in the development of cataracts by causing structural and functional changes in lens proteins and impairing lens cell function.
- Impaired antioxidant defense mechanisms: Steroids can suppress the activity of antioxidant enzymes within the lens, such as superoxide dismutase and glutathione peroxidase, which protect against oxidative damage. Reduced antioxidant capacity can exacerbate oxidative stress and contribute to the progression of cataracts.
I've actually never heard of it before you mentioned it, but now im kind of interested in reading more about this. Never heard of anyone else having these symptoms either, but theoretically it does seem possible, but it does not seem specific to masteron itself, nor does it seem common.
