Mifepristone to shut down all receptors

[Frozen]

Watching a Leo Longevity podcast where he talks about decreasing long ester testosterone, then increasing a short ester, so you can then cut test completely and take mifepristone which shuts down all receptors allowing the androgen receptors to reset within 1-2 weeks. This would be in place of say a pct or cruise. I’m looking for more input and if this is actually an idea to look into.

 

[susuzadam]

Watching a Leo Longevity podcast where he talks about decreasing long ester testosterone, then increasing a short ester, so you can then cut test completely and take mifepristone which shuts down all receptors allowing the androgen receptors to reset within 1-2 weeks. This would be in place of say a pct or cruise. I’m looking for more input and if this is actually an idea to look into.

Do you remember which video it is? I'm considering taking anti progesterone compound.

 

[Mac11wildcat]

What is this mythical androgen receptor reset? AAS use upregulates, not deregulates receptors. This is unnecessary complication for no gain whatsoever.

We don’t cruise for receptors. We cruise for health and because continuing to drive change requires more training and more food and it cannot be sustained indefinitely.

 

[Type-IIx]

Correct me if I am wrong please, but wasn't Leo weeded out of the gene pool by an early demise, despite his practices being purported as for "longevity" or "anti-aging"?

Do not take mifepristone you fool.

Are you aware of what this drug is used for clinically? Are you aware of its being tightly regulated, and that you are at best depriving a woman who actually needs it in a desperate scenario by having to resort to the grey market?

 

[Juicedhead]

hahaha wtf are you thinking dude you want to shut down your androgen receptors? They up regulate when youre on gear so wtf are you talking about reset your receptors? If gear doesnt work for you your diet is shit your training is shit or your genetics are absolute shit bro stop trying to find ways to "reset your receptors" there is no such thing you dont build tolerance to gear bro

 

[susuzadam]

What is this mythical androgen receptor reset? AAS use upregulates, not deregulates receptors. This is unnecessary complication for no gain whatsoever.

We don’t cruise for receptors. We cruise for health and because continuing to drive change requires more training and more food and it cannot be sustained indefinitely.

OK, I use tren with e2, I still get knee pain, and libido drop.

I can't shoot test anymore, and dht's. Made me feel infinitely rage against all people. Tried it few times with eliminating test prop for 9 days, then shooting it again.

Seems like tren activating and upregulating progesterone receptors, that downregulates estrogen receptors. So I dont have enough e2 receptor activation.

Normally without exogenous e2 I get horrendous back pain, cant deadlift or squat, no sex drive, no libido or so plus if I add high test to it, I get disgusting rage.

That started with tren ace, and maybe I aggrevated it with aromasin crashes and proviron + low test.

I shot 80mg e2 val IM a week, and my e2 showed 2565 pg/ml still not enough e2 receptor activation.

What options do i have to continue to use tren?
@Type-IIx



I'm serious, I dont want to shoot test now, But still I dont have enough e2 activation.
Idk if ella (ulipristal acetate) works, and if it works, how much? Because its very expensive.

Do you think It's worth trying ella @Type-IIx ?
Or what should I do to downregulate my progesterone receptors and upregulate estrogen receptors, and how can I make this happen faster?

Edit: I've never had high e2 symptoms with levels above

 

[Juicedhead]

Oh and by the way leo and shortgevity knew fuck all about gear anyone can regurgitate wikipedia.

 

[Type-IIx]

OK, I use tren with e2, I still get knee pain, and libido drop.

I can't shoot test anymore, and dht's. Made me feel infinitely rage against all people. Tried it few times with eliminating test prop for 9 days, then shooting it again.

Seems like tren activating and upregulating progesterone receptors, that downregulates estrogen receptors. So I dont have enough e2 receptor activation.

Normally without exogenous e2 I get horrendous back pain, cant deadlift or squat, no sex drive, no libido or so plus if I add high test to it, I get disgusting rage.

That started with tren ace, and maybe I aggrevated it with aromasin crashes and proviron + low test.

I shot 80mg e2 val IM a week, and my e2 showed 2565 pg/ml still not enough e2 receptor activation.

What options do i have to continue to use tren?
@Type-IIx

View attachment 269876

I'm serious, I dont want to shoot test now, But still I dont have enough e2 activation.
Idk if ella (ulipristal acetate) works, and if it works, how much? Because its very expensive.

Do you think It's worth trying ella @Type-IIx ?
Or what should I do to downregulate my progesterone receptors and upregulate estrogen receptors, and how can I make this happen faster?

Trenbolone and progestagenic androgens increase estrogen sensitivity (in, e.g., breast tissue) [1]. Estrogens up-regulate PR synthesis (increase progesterone receptor #) [1]. There is no rationale for a man taking exogenous estrogens [2].

I have given a flowchart for decisionmaking in treating symptoms of low estrogenicity in my article about Primo & EQ "crashing" E2. [3]:

Please consider that your reported symptoms of low estrogenicity:

Normally without exogenous e2 I get horrendous back pain, cant deadlift or squat, no sex drive, no libido or so plus if I add high test to it, I get disgusting rage.

are not sine qua non effects of low estrogenicity, but rather, can be influenced (and more commonly are in our population) by overtraining, drug (e.g., AIs, SERMs) & psychological factors (e.g., sexual function is particularly subject to psychological perturbations).

References (informal; not AMA formatted):
[1] Article on distinguishing progestins, prolactin, and progestagenic androgens (e.g., Tren, MENT, Deca) & SERM vs. AI logic
[2] Why you should NOT take estrogens (Exogenous E2 ≠ Test's aromatic product)
[3] Web Article: Primo and/or EQ Crashed my E2! - Help!

Additional suggested reading: The Myth of Desensitization to AAS & The Modes of AR Regulation

 

[Type-IIx]

P.S. If you get rage from high testosterone, you might consider life-long abstinence from AAS, since it should not have any such effect.

 

[susuzadam]

Please consider that your reported symptoms of low estrogenicity

Thank you so much for response.

My back and knee pain lasted for 1 year. Started with starting tren-ace, proviron, low test.

I always took caber though.

I tried eliminating tren 3 different times, each time my libido and sex drive went up.
I tried shooting tren while I'm trt dose test. No sex drive for 24 hours, no libido for 12 hours without enough e2.

I tried not shooting anything, after 2565 e2 showed up, my libido went up as tren and test cleared out of my system.
I reintroduced the test, and libido got a hit.

If I dont have test and e2, I feel like monks,
If I have test and dont have e2, I feel just no mercy rage at everyone else.

I was powerlifting and had normal lifts, great form. But that low e2 made my knees ache while im not doing any lower body work. I couldn't squat and deadlift for 1 year because of that.
Now with exo e2 my libido went up a bit, and I can deadlift after 1 year, I just changed that.

What should I do to not take e2, and get enough e2 receptor activation?
I know tren doing all of this, but cant I fix the problem in any way?

 

[susuzadam]

P.S. If you get rage from high testosterone, you might consider life-long abstinence from AAS, since it should not have any such effect.

I don't have rage normally, really. Took test and anadrol for 1 years or so, anadrol on and off. I just get rage when e2 is low. I can't function.

 

[Isrrike]

My wife had to take that when we first started dating and had an accident. She said it was the worst 12 hours of her life and would rather die than go through what she went through again

 

[jJjburton]

I don't have rage normally, really. Took test and anadrol for 1 years or so, anadrol on and off. I just get rage when e2 is low. I can't function.

Ahhh, then keep e2 higher? E2 low sucks, and dont run tren…very simple ways to avoid what your saying…

 

[Astartes]

Watching a Leo Longevity podcast where he talks about decreasing long ester testosterone, then increasing a short ester, so you can then cut test completely and take mifepristone which shuts down all receptors allowing the androgen receptors to reset within 1-2 weeks. This would be in place of say a pct or cruise. I’m looking for more input and if this is actually an idea to look into.

AR desensitization and resetting has been debunked over… and over… and over… and ooooooooover. Please let it go away….

 

[micro2000]

How to induce Addison's Disease in 1 easy step.

 

[Inspired]

Watching a Leo Longevity podcast where he talks about decreasing long ester testosterone, then increasing a short ester, so you can then cut test completely and take mifepristone which shuts down all receptors allowing the androgen receptors to reset within 1-2 weeks. This would be in place of say a pct or cruise. I’m looking for more input and if this is actually an idea to look into.

You really have to do your homework on this, but it certainly looks interesting.

Resetting the Stress System with a Mifepristone Challenge - PubMed

Psychotic depression is characterized by elevated circulating cortisol, and high daily doses of the glucocorticoid/progesterone antagonist mifepristone for 1 week are required for significant improvement. Using a rodent model, we find that such high doses of mifepristone are needed because the...

pubmed.ncbi.nlm.nih.gov

 

[Inspired]

AR desensitization and resetting has been debunked over… and over… and over… and ooooooooover. Please let it go away….

I think he misspoke. He's probably referring to glucocorticoid/progesterone receptors etc.

 

[RomanMVP]

What is this mythical androgen receptor reset? AAS use upregulates, not deregulates receptors. This is unnecessary complication for no gain whatsoever.

We don’t cruise for receptors. We cruise for health and because continuing to drive change requires more training and more food and it cannot be sustained indefinitely.

Good post, Mac. Been waiting for someone to clear up some of this nonsense, Jesus, Mary and Joseph.

 

[susuzadam]

Estrogenic and progestational activity of 7alpha-methyl-19-nortestosterone, a synthetic androgen - PubMed

Synthetic androgens exhibit estrogenic/antiestrogenic and progestational activities in addition to their androgenic effects. To investigate the pharmacological action of the synthetic androgen, 7alpha-methyl-19-nortestosterone (MENT), we examined its action in female rodents. The criteria...

pubmed.ncbi.nlm.nih.gov

MENT's possible anti-estrogenic effect.

 

[shartking]

Ahhh, then keep e2 higher? E2 low sucks, and dont run tren…very simple ways to avoid what your saying…

How come it sounds so simple and non neurotic when you say it?