Mixing tesamorelin and hgh

[Letits now]

I may consider this as well as GH has crippled me and after year and half of using it I wont go back. I have been reading on Tesa just same issues with anything, quality source and reliability of it being there.

Can you explain the “crippled you” comment?

 

[benfrankparkway]

Can you explain the “crippled you” comment?

Tendon pain in my knees I could barely squat bodyweight. Knees ached all day. I would wake up in the morning and bottom of my feet hurt where I would walk down steps in the morning holding onto the wall and railing. Low back was brutal I couldn't stand long. Elbows and wrist lost strength; wrist lost most of their mobility.

 

[benfrankparkway]

Because Tesa was primarily tested on a pretty sickly population, a lot of potential drug interactions were observable in trials. A lot of subjects were on AAS, ie, Testosterone.

TLDR, if you're taking any diabetes drug, keep an eye on glucose levels. That's about it.

It's also mentioned that if you have a disease impacting the HPA axis, it may not be suitable. Given that growth hormone does this, perhaps best to avoid combing them.

Here are the drug interactions.

Tesamorelin Drug Interactions - Drugs.com

48 drugs are known to interact with tesamorelin.

www.drugs.com

Tesa contraindications are in here https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022505s000lbl.pdf

reading thru some of the precautions and contradictions. I see side effects listed are very similar to side effects I experienced with GH; Arthralgia, Carpal Tunnell.

Makes me want to tread lightly as I don't want to end up in the same boat as I was with GH

 

[JuiceStick]

Remember, unlike Sermorellin and Ipamorelin, Tesa is FDA approved and has 20 years of use demonstrating its relative safety. And instead of just shoving in extrogenous synthetic GH, you're producing your own, the best kind, along with numerous "side products" that are excreted with GH, many of which we don't know the purpose of, but likely evolved to accompany GH for a reason.

Sermorelin is FDA approved. It's just no longer manufactured in FDA approved form, but I have a script for compounded version.

I do prefer CJC no DAC due to PIP - with comparable doses for therapeutic effect, CJC has the least PIP for me. Sermorelin is the worst, followed by Tesamorelin. But I read Tesamorelin is better for long term use.

 

[Ghoul]

reading thru some of the precautions and contradictions. I see side effects listed are very similar to side effects I experienced with GH; Arthralgia, Carpal Tunnell.

Makes me want to tread lightly as I don't want to end up in the same boat as I was with GH

The actual incidence of those sides is much lower with Tesa vs GH. My personal experience, having had GH sides, was that there were none with Tesa compared to 2-5iu GH.

There are strong site reactions with Tesa. and I recommend filtering to reduce/eliminate that.

 

[JuiceStick]

I filter all of my peptides, including compounding pharma, and post-injection burn 2-3 minutes after injection was still there for both Tesamorelin and Sermorelin. There's almost no burn for me for 1:1 Mod GRF + Ipamorelin mix. Of course, also filtered.

 

[Ghoul]

Sermorelin is FDA approved. It's just no longer manufactured in FDA approved form, but I have a script for compounded version.

I do prefer CJC no DAC due to PIP - with comparable doses for therapeutic effect, CJC has the least PIP for me. Sermorelin is the worst, followed by Tesamorelin. But I read Tesamorelin is better for long term use.

I stand corrected, thank you.

Still, Tesa being in continuous use as a pharma produced product, and subject to ongoing FDA surveillance, further strengthens its safety record.

They even came out with a new formulation, Egrifta F8, more concentrated for lower volume injections. The brakes were applied by the FDA because they wanted evidence this more concentrated formula didn't cause immunogenicity problems.

 

[benfrankparkway]

The actual incidence of those sides is much lower with Tesa vs GH. My personal experience, having had GH sides, was that there were none with Tesa compared to 2-5iu GH.

There are strong site reactions with Tesa. and I recommend filtering to reduce/eliminate that.

i wish there was a filtering guide on this forum, I am still reading up on it and best practices on how to apply it.

 

[undersc0re]

Filtering it as in, drawing it all out of the vial thru a needle filter, then putting on a normal needle and injecting it all back into the same vial?

 

[songsofpyramids]

Filtering it as in, drawing it all out of the vial thru a needle filter, then putting on a normal needle and injecting it all back into the same vial?

Into a new sterile by fda standards vial.

 

[benfrankparkway]

Filtering it as in, drawing it all out of the vial thru a needle filter, then putting on a normal needle and injecting it all back into the same vial?

right what type of filter what size of needle and sterile vial

 

[Ghoul]

right what type of filter what size of needle and sterile vial

Get these supplies and I'll give
you step by step directions.

For peptides:

13mm .22um PES filters

Sterile 0.2 μm PES Syringe Filters

Hydrophilic PES syringe filters with single or double-layer membrane. Pore sizes of 0.2μm. Diameter of 13mm/25mm/33mm with Luer lock. Sterile individually packed. Used for sterile filtration of protein solutions, cell culture media, and buffers.

shop.cobetter.com

BD 3ml Luer Lock syringes

3mL Syringes with PrecisionGlide Needle & Luer-Lok Tip

3mL Syringe with Needle by BD Becton Dickinson Hypodermic PrecisionGlide Needle with Luer-Lok Syringe combination with regular bevel, regular wall and detachable needle.

www.vitalitymedical.com

FDA spec vials

Buy Ultra Spec Sterile 2ml Clear Sealed Glass Vials at wholesale prices

In order to receive vials in sealed shrink wrap boxes, please order in multiples of 25

www.medical-and-lab-supplies.com

 

[tokorealand]

I'm making some broad generalizations here, since we don't know your baseline and I'm no expert on this topic.

2iu of HGH or 2mg of Tesa will, according to studies I've read, on average raise IGF by around 100.

Assuming you're around the mean for your age, 112, either would push you to the top of the normal range, which sounds ideal for anti-aging.

Personally I'd use Tesa alone for this purpose. Don't have the timing concerns of hgh, as long as you take Tesa at the same time each day, and it seems "safer" to me for long term (lifetime use). I like the idea of keeping natural GH release and regulation systems intact, but I don't have much to prove this is better than straight GH.

My IGF(28M) is at 51 (range: 34-246 ng/ml) so if I want to be on the high end of normal, I’d need about 3-4 IU a day?

 

[Ghoul]

My IGF(28M) is at 51 (range: 34-246 ng/ml) so if I want to be on the high end of normal, I’d need about 3-4 IU a day?

My "100ng" increase was based on what the averages for someone around 50 was reported by different studies for either 2mg Tesa or 2iu HGH.

Other than saying i2mg Tesa won't push you over your physiologic range, I really don't know what you can expect from 3-4iu/day. It's a fairly common dose, and not going to induce acromegaly so give it a try and check levels. Type IIx in the GH expert here, and just published a comprehensible book on it that's probably the best guide you can get.

 

[songsofpyramids]

My IGF(28M) is at 51 (range: 34-246 ng/ml) so if I want to be on the high end of normal, I’d need about 3-4 IU a day?

Only testing igf1 again after 4-6 weeks (6 being better) at stable dose of hgh will tell you that. You could be a hyper responder or null responder and only testing can tell you.

 

[tokorealand]

Alright I’ll titrate myself up from 1IU to 4IU(week at each dose) and then test after 2 weeks on 4IU! I saw his book, but the shipping kills it tbh.

 

[undersc0re]

Get these supplies and I'll give
you step by step directions.

For peptides:

13mm .22um PES filters

Sterile 0.2 μm PES Syringe Filters

Hydrophilic PES syringe filters with single or double-layer membrane. Pore sizes of 0.2μm. Diameter of 13mm/25mm/33mm with Luer lock. Sterile individually packed. Used for sterile filtration of protein solutions, cell culture media, and buffers.

shop.cobetter.com

BD 3ml Luer Lock syringes

3mL Syringes with PrecisionGlide Needle & Luer-Lok Tip

3mL Syringe with Needle by BD Becton Dickinson Hypodermic PrecisionGlide Needle with Luer-Lok Syringe combination with regular bevel, regular wall and detachable needle.

www.vitalitymedical.com

FDA spec vials

Buy Ultra Spec Sterile 2ml Clear Sealed Glass Vials at wholesale prices

In order to receive vials in sealed shrink wrap boxes, please order in multiples of 25

www.medical-and-lab-supplies.com

Not sure if asking about sources for things like the syringe filters and quality vials is frowned upon, but finding them in Canada is quite difficult, especially that spec of filter.

 

[Ghoul]

Not sure if asking about sources for things like the syringe filters and quality vials is frowned upon, but finding them in Canada is quite difficult, especially that spec of filter.

Sources only applies to PEDs.

Cobetter linked above ships to Canada. 2-3 day express $30. Still a good overall price. Consider .22 PTFE 25mm if you want to filter oils as well.

 

[undersc0re]

Just out of curiosity, if I were to reconstitute 10mg tesa with 1 ml bac and then filter that into another vial, how much material would you lose in the process, and with such small amounts is it worth it chancing getting contaminants into it during this process somehow, I assume very little loss and no contamination, otherwise you wouldn’t suggest it but just want to make sure it is worth it for stuff like 99.6% tesa or at least they say its that pure.

 

[keenpen]

Just out of curiosity, if I were to reconstitute 10mg tesa with 1 ml bac and then filter that into another vial, how much material would you lose in the process, and with such small amounts is it worth it chancing getting contaminants into it during this process somehow, I assume very little loss and no contamination, otherwise you wouldn’t suggest it but just want to make sure it is worth it for stuff like 99.6% tesa or at least they say its that pure.

Peptide test answers this question here

Syringe Filter Impact Study — Peptide Test

www.peptidetest.com

Loss is 5-7 units for a 4mm and 29 units for a 13mm. I use a 4mm filter for peptides because of this.