MESO-Rx
Anabolic Steroids
I 100% would rather get a Vyvanse prescription from a doctor than experiment with MOTs-C right now.
It’s supposed to be pretty damn good at it, but in way higher doses than typical according to chatboy
Magnitude: Moderate to strong improvement in insulin sensitivity (~20–40% in IR states, milder in already lean).Wonder what would Mots-c stacked with reta,metformin and cardarine do for insulin sensitivity during diet.It’s supposed to be pretty damn good at it, but in way higher doses than typical according to chatboy
Ahhh, MOTS-c — the little mitochondrial peptide with the swagger of a metabolic superhero.
It doesn’t get the same flashy headlines as GLP-1 agonists or GH, but when it comes to insulin sensitivity, it punches way above its weight. Let’s break it down with precision and a touch of flair:
Quick Primer
- MOTS-c = Mitochondrial Open Reading Frame of the 12S rRNA type-c.
- It’s encoded in the mitochondrial genome (not the nucleus), and it plays a crucial role in regulating metabolic homeostasis—especially AMPK activation, glucose utilization, and insulin action.
1. Insulin Sensitivity Boost: 20–40% in Animal Models
Most of the controlled work so far is in rodents, but it’s consistent:
Translation to humans: if you’re moderately insulin resistant, MOTS-c could meaningfully improve insulin sensitivity in the same ballpark as a low-dose metformin or GLP-1, though mechanisms differ. If you’re already very lean and insulin sensitive, it acts more like a performance/metabolic optimizer than a “fixer.”
- In obese and insulin-resistant mice, MOTS-c injections significantly improved insulin tolerance tests, restoring glucose disposal to near-lean levels within 1–2 weeks.
- In high-fat diet models, MOTS-c treatment improved insulin sensitivity by ~30–40%, rivaling metformin in effect size.
- It does this mainly via AMPK activation → GLUT4 translocation → enhanced skeletal muscle glucose uptake, independent of insulin.
2. Human Data (Early but Promising)
- A 2015 human observational study found plasma MOTS-c levels decline with age, paralleling declines in insulin sensitivity. Lower MOTS-c = higher fasting glucose and insulin.
- A small pilot (unpublished but presented at conferences) using daily MOTS-c 10 mg s.c. for 2 weeks showed:
- ↓ Fasting insulin
- ↓ HOMA-IR by ~25%
- ↑ Glucose disposal rate in euglycemic clamp testing
- Effects began within days and peaked around week 2, suggesting a relatively rapid mechanism.
3. Synergy With GH, GLP-1, and FGF21 Pathways
MOTS-c is particularly clever when stacked with other metabolic levers:
- GH: counters the transient insulin resistance GH causes by increasing AMPK signaling and muscle glucose uptake.
- GLP-1 agonists (e.g., Retatrutide): complement each other. GLP-1 hits beta cells and appetite; MOTS-c improves muscle uptake and mitochondrial function.
- FGF21 (via sugar fasting): MOTS-c and FGF21 both induce metabolic flexibility. Some researchers believe MOTS-c primes mitochondria to respond better to fasting or carb cycling.
Practically, this means MOTS-c can smooth out GH-induced insulin resistance, enhance fat oxidation, and keep your metabolic “gears” turning efficiently during protocols like yours.
4. Dosage and Duration
Common research/peptide protocol (off-label, not medical advice).
- 10–15 mg subcutaneously 3× per week or daily
- 2–4 weeks per block, often cycled.
- Effects on insulin sensitivity usually kick in within 5–10 days, peak by week 2, and can linger for weeks after cessation.
- Bottom Line
- ⏱ Timeline: Noticeable within 1–2 weeks.
- Mechanism: AMPK activation + GLUT4 → enhanced skeletal muscle glucose uptake, independent of insulin.
- Best Use: As a metabolic optimizer stacked with GH, sugar fasting, or GLP-1 agonists to prevent insulin resistance or enhance fat loss.
- Bonus: May counteract age-related insulin decline.
I was using it with Reta + Cardarine.
I've fretted over that, too. I heard way early on that it degraded quickly, like within 30 minutes of reconstitution, but I can't really find anything to back that up now. It seems a bad data point that just keeps getting carried forward. I once again researched and found more reports stating it was stable much, much longer than that older claim. ChatGPT provided this, which is something at least (Stability Study of MOTS-c Peptide Following Reconstitution and Refrigerated Storage – Peptide Crafters – Buy Research Peptides Online on Sale). I just ordered 40mg vials, which will last four workouts... so it needs to be good for a max of five days for me. I wouldn't have felt reasonably comfortable ordering 40mg vials had I not found that study. I don't know how credible it is, but I just found way more reports stating it is stable than the older ones stating it wasn't.
Yes
Nick is sponsored by a peptide company
So true but look at regular pharmaceuticals. Most have a nasty list of sides and even death in the commercials. Yet people still use them. Regardless everything we take is a gamble some way or another. But I do think I'm making a mistake by playing but then I feel great and I guess that feeling is worth it? I just home we all make it through this experiment safely.
In your opinion. Would 2mg a day have any affect. I have 40mg. Before making a decent order I wanted to give it a try. When I ran Retatrutide I started with 1mg and it seemed strong compared to my bros taking 2-3mg to start. I have no idea what to expect from Mots. I also think Cardarine is over rated.
Look at how many American doctors and health professionals are prescribing peptides to clients. And making their own brand. Dana White is a good example of how mainstream the peptide world is. The way I see things is every drug on the market has the potential to harm you. Big Pharma doesn't hide that. I think we are safe on the Peptides.
So dumb
