nervousness causing loss of erection

[foreveryoung]

I recall reading things about this, please someone here refresh my memory, about how something about getting too nervous releases something (epinephrine?) and that is what causes an erection loss even if everything else is optimal for erection.

and secondary to that concept, what would be things that would directly work on preventing that chemical release from stress that also wouldn't interfere with the other important chemicals that must be in perfect balance for optimal erection and orgasm

would propranolol work to help prevent this issue, and also not affect dopamine and or any other things that are required for erection function to be optimal?

all and any serious scientific thoughts on this topic would be appreciated

 

[James23]

Perhaps you could refrain from having 5 orgasms per day. That ought to make sustaining an erection more likely at 50+ years old.

 

[Demondosage]

Hahahhahahhahahaha

 

[corageon]

I recall reading things about this, please someone here refresh my memory, about how something about getting too nervous releases something (epinephrine?) and that is what causes an erection loss even if everything else is optimal for erection.

and secondary to that concept, what would be things that would directly work on preventing that chemical release from stress that also wouldn't interfere with the other important chemicals that must be in perfect balance for optimal erection and orgasm

would propranolol work to help prevent this issue, and also not affect dopamine and or any other things that are required for erection function to be optimal?

all and any serious scientific thoughts on this topic would be appreciated

No, not propranolol. You want alpha-blockers then, alpha-receptors vasoconstrict, beta receptors vasodilate.

Alpha-Blockers are Phentolamine, Yohimbine, Doxazosin, Prazosin. The bolded are preferable as yohimbine causes more anxiety generally.


Also increase GABA, and do other things to relieve stress, i.e; drink more water, get adequate zinc, magnesium, DHA.

 

[Dr JIM]

FY
Describe EXACTLY what happens, under what circumstances, it's duration etc.

Arn'e you taking some other meds mate?

Any PMH?

I ask because these can certainly be causative or contributing factors.

Understand an "erection" is a very COMPLEX process which involves hormonal alterations, the peripheral and autonomic nervous systems, the actions of both skeletal and smooth muscle (voluntary and involuntary).

Moreover the interactions of all the above becomes integrated within the CNS especially the "limbic" system to develop a 'response" or lack thereof.

The point, it's quite unusual for one drug, such as beta blockers or alpha/beta agonists like epinephrine, to specifically modify all of those physiological processes thereby enhancing the duration, frequency, or timing of an erection. (The existing
exceptions the currenty available ED drugs such as Viagra, Levitra)

best
jim

 

[corageon]

FY
Describe EXACTLY what happens, under what circumstances, it's duration etc.

Arn'e you taking some other meds mate?

Any PMH?

I ask because these can certainly be causative or contributing factors.

Understand an "erection" is a very COMPLEX process which involves hormonal alterations, the peripheral and autonomic nervous systems, the actions of both skeletal and smooth muscle (voluntary and involuntary).

Moreover the interactions of all the above becomes integrated within the CNS especially the "limbic" system to develop a 'response" or lack thereof.

The point, it's quite unusual for one drug, such as beta blockers or alpha/beta agonists like epinephrine, to specifically modify all of those physiological processes thereby enhancing the duration, frequency, or timing of an erection. (The existing
exceptions the currenty available ED drugs such as Viagra, Levitra)

best
jim

It certainly is complex. But it generally comes down to the enzyme nNOS (neuronal nitric oxide synthase) in the spinal and medial preoptic area, of which is triggered or altered by second messengers and neurotransmitters.
Dopamine,Vasopressin,Glutamate,GABA,Acetylcholine,Oxytocin all contribute to this effect.
Potassium Channels, Sodium Channels and Calcium channels all help mediate this effect as well.

 

[foreveryoung]

It certainly is complex. But it generally comes down to the enzyme nNOS (neuronal nitric oxide synthase) in the spinal and medial preoptic area, of which is triggered or altered by second messengers and neurotransmitters.
Dopamine,Vasopressin,Glutamate,GABA,Acetylcholine,Oxytocin all contribute to this effect.
Potassium Channels, Sodium Channels and Calcium channels all help mediate this effect as well.

can you elaborate a bit? I can get oxytocin, is this helpful?

and to Dr. Jim, this is not a new thing, I am on no other meds either, it happened to me before as a young man with extreme libido, being with a new girl the nervousness would sometimes sabotage and limp dick would result.

by going overboard now on the supplements it is the hope that erection would be so involuntary as to overpower any nervousness sabotage, and to a good extent it works well for that, but I wish to avoid all of these side effect causing supplements if I can figure something else out to calm the nervous reaction that causes the issue

 

[Dr JIM]

Well gosh Coregon if it was as SIMPLE as you have suggested ED or nervousness, as a medical entity, wouldn't exist because therapy would be relatively straightforward and effective.

Shit you just named roughly 8 factors which contribute to either anxiety and or an erection. The problem, when one of these substrates is altered doing so also effects the response or responses mediated by the others.

Fact is NOT ONE of the chemical or enzymatic reactions you mentioned can be manipulated in ISOLATION with existing medical therapy.

So FY what Coregon has offered as therapeutic can NOT be applied clinically and is essentially esoteric BS!

Jim

 

[corageon]

Well gosh Coregon if it was as SIMPLE as you have suggested ED or nervousness, as a medical entity, wouldn't exist because therapy would be relatively straightforward and effective.

Shit you just named roughly 8 factors which contribute to either anxiety and or an erection. The problem, when one of these substrates is altered doing so also effects the response or responses mediated by the others.

Fact is NOT ONE of the chemical or enzymatic reactions you mentioned can be manipulated in ISOLATION with existing medical therapy.

So FY what Coregon has offered as therapeutic can NOT be applied clinically and is essentially esoteric BS!

Jim

OK, where are the shrooms that your using? I want some.
There is not one suggestion in my response that said manipulating "one chemical or enzymatic pathway in isolation" would cure the problem. I said they all contribute as factors. Be careful when viewing sentences that aren't there.

Also, every one of these has been tested, and if you want links...I can gladly provide, and no they are not articles. Always reliable.

Also one therapy may not work for everyone, you could have a crazy "deficiency" of one neuropeptide (like oxytocin), and have sufficient vasopressin, DA, Ach, etc, and be alright. Anxiety does happen to work through similar mechanisms; obviously there has to be a balance between the parasympathetic and sympathetic nervous systems.

 

[corageon]

Oxytocin may help. Keep in mind Testosterone plays a role in the maintenance of oxytocin receptors.

Oxytocin is generally seen as a "socializing" chemical, and has been shown to relieve anxiety in some studies (1) (2).

Oxytocin has a direct effect on erections through the Nitric Oxide pathway as I said.(3)



Oxytocin levels in social anxiety disorder. [CNS Neurosci Ther. 2008] - PubMed - NCBI

Oxytocin levels in social anxiety disorder.​

Abstract​

Oxytocin is a neuropeptide recently associated with social behavior in animals and humans, but the study of its function in populations with social deficits such as autism, schizophrenia, and social anxiety disorder has only recently begun. We measured plasma oxytocin in 24 patients with Generalized Social Anxiety Disorder (GSAD) and 22 healthy controls using an enzyme-linked immunosorbent assay. There were no significant differences in oxytocin level (pg/mL) between patients (M=163.0, SD=109.4) and controls (M=145.0, SD=52.9, z=0.21, P=0.8). Within the GSAD sample, however, higher social anxiety symptom severity adjusted for age and gender was associated with higher oxytocin level (R2=0.21, beta=0.014, SE=0.006, t=2.18, P=0.04). In addition, dissatisfaction with social relationships was associated with higher oxytocin levels (R2=0.18, beta=-0.20, SE=0.10, t=-2.01, P=0.05). Our data provide preliminary support for a link between social anxiety severity and plasma oxytocin. These findings may suggest a possible role for oxytocin as a facilitator of social behavior, an effect which may not be fully utilized in individuals with severe social anxiety.​

 

[foreveryoung]

how close to the "act" would one need to inject oxytocin to experience any effect?

 

[Dr JIM]

Fine but where did your "study" suggest providing a PARENTERAL drug like oxytocin may be beneficial therapeutically for "nervous" patients?

There are many neurotransmitters involved in human behavior but manipulating their levels either locally or systemically for clinical benefit is much more challenging.

So what do you have to offer the OP from a therapeutic perspective. Go to the OB ward and pin some "oxy", lol!

L

 

[foreveryoung]

actually I have a good source for oxytocin but haven't experimented with it yet

 

[Dr JIM]

Experimentation is exactly what it would be!

 

[James23]

Oxytocin appears to have a half life of 3 minutes in the blood. So, you'd have to inject all evening and right up to the act itself.

 

[Dr JIM]

No doubt, such a short half life is the reason Oxytocin is prescribed as a parenteral
drip when used in OB to enhance uterine contractions during delivery.

 

[MR10X]

Try this,works extremely well....
[ame=http://en.wikipedia.org/wiki/Bremelanotide]Bremelanotide - Wikipedia, the free encyclopedia[/ame]

 

[foreveryoung]

Try this,works extremely well....
Bremelanotide - Wikipedia, the free encyclopedia

you must have missed my other thread where I mentioned this was already part of my "extreme supplementation" protocol.... it helps for sure, but adds to the feeling of total shit


and also, this stuff does nothing for the nervousness issue really, it can help overcome very slight nerves, but if a big shot of nervousness hits it really is powerless

 

[corageon]

you must have missed my other thread where I mentioned this was already part of my "extreme supplementation" protocol.... it helps for sure, but adds to the feeling of total shit


and also, this stuff does nothing for the nervousness issue really, it can help overcome very slight nerves, but if a big shot of nervousness hits it really is powerless

They also have oxytocin "sprays", because oxytocin is also a pheromone, it may actually be more effective this way. A long time ago I "experimented" with oxytocin sprays for mild anxiety...it has since disappeared when I turned 18.
Oxytocin is involved with the passion, love and trust in a relationship, but it has been shown to improve communication skills in autistic patients.

It had more of an effect on the people around me tbh. Your internal and natural oxytocin is regulated by histamine, dopamine, serotonin (especially), glutamate, testosterone, estrogen, prolactin etc.(1)[URL="http://www.jneurosci.org/content/22/5/1513.full.pdf"](2)[/URL]

It is proposed as the reasoning for ecstasys increase in socialization and empathy. Keep in mind though some people are born with less oxytocin receptors naturally, some people have a gene that alters the way oxytocin is used(!). Considering it is highly inhibitory upon the amygdala's fear response(!), it should tell ya something.(!)

 

[Dr JIM]

Yea what it tells me is your implying neurochemical bench research has direct clinical applications. Really!

Let's see the CLINICAL TRIALS first fella.

How about a trial where oxytocin was used to modify "nervousness", LOL!