Turbo1
New Member
WHOA!!!!
I"m I really reading this??
I"m I really reading this??
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MaxRep said:First of all, everyone should realize this thread and the posts by je61 are a complete joke. I doubt je16 is really 16. Much more likely, it's just some ahole trying to push everyone's buttons and cause a big ruckus, and it looks like he's succeeded. His style reminds me of HUlk18. Remember the kid who claimed 20" arms at 175 pounds? I wouldn't be surprised if it were the same person. It's best to just ignore people like this.
Second, and the real reason for my post, there seems to be a misunderstanding as to why a person's growth is stunted by the use of steroids....."
MAX - For the reason stated in your first paragraph, I did not take the time to cite a study like....
"""""Published online before print May 29, 2001, 10.1073/pnas.121180498
Proc Natl Acad Sci U S A. 2001 June 5; 98 (12): 68716876
DOI: 10.1073/pnas.121180498
Medical Sciences
Effects of estrogen on growth plate senescence and epiphyseal fusion
Martina Weise,* Stacy De-Levi, Kevin M. Barnes, Rachel I. Gafni, Veronica Abad, and Jeffrey Baron
In some mammals, including humans, the growth plate is resorbed at the time of sexual maturation. This process, epiphyseal fusion, terminates longitudinal bone growth. Estrogen is pivotal for epiphyseal fusion in both young men and women (10). This key role for estrogen was confirmed only recently with the recognition of two genetic disorders, estrogen deficiency due to mutations in the aromatase gene (11) and estrogen resistance due to mutations in the estrogen receptor-? gene (12). In both conditions, the growth plate fails to fuse and growth persists into adulthood. Conversely, premature estrogen exposure, e.g., precocious puberty, leads to premature epiphyseal fusion (13).
The mechanism by which estrogen promotes epiphyseal fusion is not known. Previous reports suggest that estrogen accelerates growth plate ossification by stimulating vascular and bone cell invasion of the growth plate cartilage, causing ossification to advance beyond the hypertrophic zone into the proliferative and resting zones (1416). This proposed mechanism of estrogen action would be expected to induce epiphyseal fusion promptly, a prediction that does not match clinical experience. Prompt fusion occurs only in estrogen-deficient adults treated with estrogen (10, 17, 18). In children, epiphyseal fusion occurs only after years of estrogen exposure. The accelerated ossification hypothesis does not readily explain this delayed action."""""
******* For the same reason people associate steroid use or (excess, obviously exogenous ,testosterone) with gyno, I thought it more convienent to associate with high test levels with stunted bone growth. *******
MaxRep said:No problem Machi. I know you understand but many people think it is the steroid itself which stunts growth. The information you posted along with many recent studies show growth stops due to estrogen.
MaxRep
finafreak said:Wow,.estrogen stunts the growth to kids now>?
fina
wtf?KOMT said:You'll shoot your eye out, officer.
