Longtime longevity dose rhGH user that recently added NMN to my protocol 30 days ago. I haven't found any research that specifically points to synergies between the two but I have noticed a fairly dramatic amplification of the positive effects of the rhGH (namely fat reduction) while using the two together. Anyone experience the same thing and/or have data that suggests this may actually be a thing?
MESO-Rx
Anabolic Steroids
NMN + rhGH
- Thread starter OldGHGuy
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clearheaded
Member
yes B vitamins have long been used in fat loss/metabolism.. also in gh boosters....
google "niacin fat loss metabolism" etc
google "niacin fat loss metabolism" etc
Yeah this effect may not relate to everyone but I definitely hit on what was a prior deficiency. Just for grins I'm going to get a vitamin profile next time I do bloods. I take Nexium for GERD and already supplement with extra Magnesium due to depletion from the drug. Could be others...
UncleBuns
Well-known Member
I am currently using 3iu GH daily as well as NMN + NR 50/50. It would be really hard for me to pinpoint the effects of NMN as I'm also on trt/HCG and low dose mast. I feel fucking great though! Not cutting currently, just maintaining but I am fairly lean for not cutting calories.
BrockSamson42
Member
Pretty sure adding NMN will never be a bad thing. It could be better than straight NAD+
We all have an idea what a replacement rHGH dose is, but I couldn't tell you what a replacement NAD+ dose is.
I think UncleBuns is at the sweet spot more or less, assuming its a nice dose of NMN. I Would shoot for 500mg to a gram a day.
We all have an idea what a replacement rHGH dose is, but I couldn't tell you what a replacement NAD+ dose is.
I think UncleBuns is at the sweet spot more or less, assuming its a nice dose of NMN. I Would shoot for 500mg to a gram a day.
clearheaded
Member
NAD and NMN are 2 very different compounds..
replacement NAD dose is not a thing... not even sure what u could be referencing..
AlexDavis43
Member
Why are people taking NMN instead of NR? Is there a biological reason or just accessibility/price?
UncleBuns
Well-known Member
I wasn't able to get to the bottom of which is better. Seems like there's not enough research to really know. So I decided to just take them both at half the dosage I would take each one individually.
clearheaded
Member
no definitive answer on what's better, products now that have both... but ya prob price and not knowing if its worth it... at least from my understanding...
lol sorry should of read uncle buns post, said the same thing...
jayteelif87
Member
There’s a new product following the 1-MNA protocol for optimizing NAD levels that was just released. Seems promising, but fairly new so not a lot of research on it it, yet. What is out there does seem to promote enhanced NAD levels better than any of the precursors in the market now though:
www.1mna.com
Inhibition of NNMT:
1-MNA has been shown to inhibit the enzyme NNMT, which when present in
high levels, is associated with various diseases. By inhibiting this
enzyme, 1-MNA can contribute to overall cellular health and disease
prevention.
Endotelio 1-MNA
1-MNA enhances overall cellular health and combats age-related diseases by optimizing NAD levels, reducing inflammation, and inhibiting NNMT.
www.1mna.com
Inhibition of NNMT:
1-MNA has been shown to inhibit the enzyme NNMT, which when present in
high levels, is associated with various diseases. By inhibiting this
enzyme, 1-MNA can contribute to overall cellular health and disease
prevention.
Last edited:
songsofpyramids
Well-known Member
This makes stoked as fuck to add nmn into my stack. Great to know there’s positive synergy
AlexDavis43
Member
There’s a new product following the 1-MNA protocol for optimizing NAD levels that was just released. Seems promising, but fairly new so not a lot of research on it it, yet. What is out there does seem to promote enhanced NAD levels better than any of the precursors in the market now though:
Endotelio 1-MNA
1-MNA enhances overall cellular health and combats age-related diseases by optimizing NAD levels, reducing inflammation, and inhibiting NNMT.
Inhibition of NNMT:
1-MNA has been shown to inhibit the enzyme NNMT, which when present in
high levels, is associated with various diseases. By inhibiting this
enzyme, 1-MNA can contribute to overall cellular health and disease
prevention.
See also research on 5-amino-1MQ. All pre-clinical but interesting.
5-amino-1MQ is available but really expensive relative to what we think it should do.
jayteelif87
Member
Actually am trying it right now, has some really good cognitive benefits as well. A lot of the Chinese vendors are starting to sell it just be careful, there’s an iodide version and a chloride version. Too much iodide can be a really bad thing.
Kdubswoldgier
Member
Thought I read nmn can convert to nr when needed in the body then convert back...
songsofpyramids
Well-known Member
I’ve read this too but I don’t think the science is conclusive.
AlexDavis43
Member
Thanks for the feedback. What is your dosing protocol?
jayteelif87
Member
Started at 50mg daily and worked my way up to 150mg daily.
AlexDavis43
Member
Nice. From the earlier mouse study I thought the human dose would be closer to 1 gram per day, but 5-amino 1MQ is so damn expensive (at least for me to run that dose); can't justify the cost.
But if you're getting benefits at 150 mg daily, that's a different story.
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