AAS are the exception to this rule because there's no alternative.
"Whatever binder" is one primary issue. Pharmacokinetics, the way in which the drug is delivered is an entire science, and pharma companies have teams of engineers who carefully formulate excipient ingredient recipes appropriate for the active ingredient. A number of important factors are taken into consideration. For instance, the wrong excipient can cause an active ingredient to "clump", leading to random "hot" tabs overdosed to a very high level. Other excipients ensure the drug is delivered to its intended destination. Metformin absorbed in the stomach has a much different, undesirable set of effects than when it's absorbed in the small intestines. An excipient selected to release the active ingredient in small intestine conditions, around ph6 is specifically chosen.
Then the excipients are ground to specific molecular sizes and sifted, before finally being mixed and pressed into a size and shape chosen by the pharma engineers, at a particular pressure,
This isn't obsessing over irrelevant details, they matter.
Meanwhile every UGL tab is typically the same size, shape and made with the same excipients.
Recently "variance" testing has finally started to be demanded, and some extreme under and overdoses are being found on a regular basis.
So, if there's no choice, there's little you can do, but if there's an India pharma option, that's far preferable to UGL. Most of the time, the India alternative is even cheaper than UGL, like Tadalafil.