Peptide advice

[Ghoul]

In the case of someone who is blasting a gram of testosterone (me) would it be better to start with a secretagogue (Tesamorelin), or just go straight to HGH?

Assuming that the objective is to get better sleep, more muscle gain, more appetite, more collagen/anti-aging.

To me. "anti-aging" means a long term commitment

In my opinion, if it's only to be used during a blast, HGH is the way to go, but if the intent is to slow and reverse the effects of aging, then Tesa is more appropriate over the long haul.

 

[mikeh1998]

To me. "anti-aging" means a long term commitment

In my opinion, if it's only to be used during a blast, HGH is the way to go, but if the intent is to slow and reverse the effects of aging, then Tesa is more appropriate over the long haul.

May I ask how you would dose this during a blast vs a cruise (cruise = 100-150 mg testosterone cypionate once per week)?

For blasting I am seeing most people run 4 IU per day of HGH. Either all at once before bed or 2 IU pre workout + 2 IU post workout, so I am thinking about starting there and titrating up or down depending on the effects.

You mentioned to start at 200 mcg Tesamorelin and titrate for a complete beginner, once I start cruising do you think I can start somewhere higher like 500 mcg/day?

Would it make sense to go up to or past 1000 mcg/day for "anti-aging"?

And does timing matter as much for Tesa, should you split it into 2 injections like people do with HGH?

I know these are a lot of questions, I am so behind in the world of peptides to the point that I don't know where to look for good information aside from searching on Meso. Thank you.

 

[Ateam2023]

May I ask how you would dose this during a blast vs a cruise (cruise = 100-150 mg testosterone cypionate once per week)?

For blasting I am seeing most people run 4 IU per day of HGH. Either all at once before bed or 2 IU pre workout + 2 IU post workout, so I am thinking about starting there and titrating up or down depending on the effects.

You mentioned to start at 200 mcg Tesamorelin and titrate for a complete beginner, once I start cruising do you think I can start somewhere higher like 500 mcg/day?

Would it make sense to go up to or past 1000 mcg/day for "anti-aging"?

And does timing matter as much for Tesa, should you split it into 2 injections like people do with HGH?

I know these are a lot of questions, I am so behind in the world of peptides to the point that I don't know where to look for good information aside from searching on Meso. Thank you.

Have you done any kind of research on this ? Just curious

 

[Ateam2023]

May I ask how you would dose this during a blast vs a cruise (cruise = 100-150 mg testosterone cypionate once per week)?

For blasting I am seeing most people run 4 IU per day of HGH. Either all at once before bed or 2 IU pre workout + 2 IU post workout, so I am thinking about starting there and titrating up or down depending on the effects.

You mentioned to start at 200 mcg Tesamorelin and titrate for a complete beginner, once I start cruising do you think I can start somewhere higher like 500 mcg/day?

Would it make sense to go up to or past 1000 mcg/day for "anti-aging"?

And does timing matter as much for Tesa, should you split it into 2 injections like people do with HGH?

I know these are a lot of questions, I am so behind in the world of peptides to the point that I don't know where to look for good information aside from searching on Meso. Thank you.

Theres a quick search hope this helps,,,,

 

[Ghoul]

May I ask how you would dose this during a blast vs a cruise (cruise = 100-150 mg testosterone cypionate once per week)?

For blasting I am seeing most people run 4 IU per day of HGH. Either all at once before bed or 2 IU pre workout + 2 IU post workout, so I am thinking about starting there and titrating up or down depending on the effects.

You mentioned to start at 200 mcg Tesamorelin and titrate for a complete beginner, once I start cruising do you think I can start somewhere higher like 500 mcg/day?

Would it make sense to go up to or past 1000 mcg/day for "anti-aging"?

And does timing matter as much for Tesa, should you split it into 2 injections like people do with HGH?

I know these are a lot of questions, I am so behind in the world of peptides to the point that I don't know where to look for good information aside from searching on Meso. Thank you.

There's no titration with Tesa. It's straight to 2mg and you stay there. Timing isn't relevant, as long as it's roughly consistent from day to day.

"Treatment with rhGH, however, results in nonpulsatile circulating GH levels and may adversely affect insulin sensitivity (18,19). Given the evidence that a pulsatile pattern of secretion may be important for many of the physiological actions of GH, a strategy to augment physiological pulsatile GH secretion may be desirable and may have less effect on insulin sensitivity than rhGH."

Tesa and rHGH serve two different purposes. Tesa seems best suited for those who want to stay within physiological limits, but at a higher level. It's only got a half life of 30 minutes, but GH release is boosted for 24 hours+.

The natural "pulsatile" release cycle is maintained. It just increases the levels released, vs ramming in GH. That's why timing of Tesa isn't critical like it is with GH.

There are animal studies showing certain benefits depend on this pulsatile release pattern.

IGF feedback remains intact as a "safety valve" preventing excessive GH levels. Important if you're using it for many years and are concerned about not accelerating cancer.

Insulin resistance isn't an issue with Tesa.

But for the bodybuilder, rHGH can deliver faster, better results, with added complexity and risk.

An older study but written in an easy to digest way vs others.

Effects of a Growth Hormone-Releasing Hormone Analog on Endogenous GH Pulsatility and Insulin Sensitivity in Healthy Men - PMC

Context and Objective: Strategies to augment pulsatile GH may be beneficial in patients with excess visceral adiposity, in whom GH secretion is reduced. The objective of this study was to determine the effects of a novel GHRH (GHRH1–44) analog, ...

pmc.ncbi.nlm.nih.gov

 

[mikeh1998]

View attachment 311409
Have you done any kind of research on this ? Just curious

Where do I even start.

OK, do research. Research where? From what source? From a blog post? From a reddit post? Is the author of that Reddit post correct? Is the information he shared in the post based actually true or is he parroting some YouTuber? What's the source of the information that the YouTuber mentioned? Was it a study? Who was the study conducted on? What were the results of the study? What doses were administered? Would those doses allow me to achieve the goal that I am looking to use this peptide for? Oh that dose was used to treat HIV patients for fat loss, I don't have HIV and my goal isn't fat loss. Does that mean the dose is too high? Well if I am using it as a PED, maybe the dose is actually too low?

Man, looks like this is getting complicated. Hmm... Looks like there's a relatively recent thread with helpful and patient posters I have interacted with before that I can ask questions and hopefully get an answer, and then people in the future can stumble upon our discussion and gain some more accurate knowledge or ask further questions.

Nah fuck all that, let's just ask an AI that is trained on /r/peptide threads made by users 2 years ago. Robot man so smart. He always know what to do. He always tell me what to buy. He best.

 

[JACNZPP]

Where do I even start.

OK, do research. Research where? From what source? From a blog post? From a reddit post? Is the author of that Reddit post correct? Is the information he shared in the post based actually true or is he parroting some YouTuber? What's the source of the information that the YouTuber mentioned? Was it a study? Who was the study conducted on? What were the results of the study? What doses were administered? Would those doses allow me to achieve the goal that I am looking to use this peptide for? Oh that dose was used to treat HIV patients for fat loss, I don't have HIV and my goal isn't fat loss. Does that mean the dose is too high? Well if I am using it as a PED, maybe the dose is actually too low?

Man, looks like this is getting complicated. Hmm... Looks like there's a relatively recent thread with helpful and patient posters I have interacted with before that I can ask questions and hopefully get an answer, and then people in the future can stumble upon our discussion and gain some more accurate knowledge or ask further questions.

Nah fuck all that, let's just ask an AI that is trained on /r/peptide threads made by users 2 years ago. Robot man so smart. He always know what to do. He always tell me what to buy. He best.

It seems like you've already found the answer to your question, my friend! I recommend diving deeper into various resources and studies for more comprehensive information.

Many forum members can get frustrated when the same questions are repeatedly asked, especially when they’ve been addressed multiple times before.

Keep researching, draw your own conclusions, and then move forward from there. Good luck!

 

[Ateam2023]

Where do I even start.

OK, do research. Research where? From what source? From a blog post? From a reddit post? Is the author of that Reddit post correct? Is the information he shared in the post based actually true or is he parroting some YouTuber? What's the source of the information that the YouTuber mentioned? Was it a study? Who was the study conducted on? What were the results of the study? What doses were administered? Would those doses allow me to achieve the goal that I am looking to use this peptide for? Oh that dose was used to treat HIV patients for fat loss, I don't have HIV and my goal isn't fat loss. Does that mean the dose is too high? Well if I am using it as a PED, maybe the dose is actually too low?

Man, looks like this is getting complicated. Hmm... Looks like there's a relatively recent thread with helpful and patient posters I have interacted with before that I can ask questions and hopefully get an answer, and then people in the future can stumble upon our discussion and gain some more accurate knowledge or ask further questions.

Nah fuck all that, let's just ask an AI that is trained on /r/peptide threads made by users 2 years ago. Robot man so smart. He always know what to do. He always tell me what to buy. He best.

i hear you, i messed around and wasted alot of time and money on gh secreatogues, and finally just hopped on hgh and found my path after trial and error in the beginning, hgh is so "individual" it seems "different doses" effect people different, no science backing , just real life experience is the only way ime/imo to justify the cost (realitivly cheap) and the means to your hgh journey,,,, Good luck on your journey

 

[mikeh1998]

It seems like you've already found the answer to your question, my friend! I recommend diving deeper into various resources and studies for more comprehensive information.

Many forum members can get frustrated when the same questions are repeatedly asked, especially when they’ve been addressed multiple times before.

Keep researching, draw your own conclusions, and then move forward from there. Good luck!

 

[mikeh1998]

i hear you, i messed around and wasted alot of time and money on gh secreatogues, and finally just hopped on hgh and found my path after trial and error in the beginning, hgh is so "individual" it seems "different doses" effect people different, no science backing , just real life experience is the only way ime/imo to justify the cost (realitivly cheap) and the means to your hgh journey,,,, Good luck on your journey

Okay thank you. Since there is so much individual variance between how people respond that makes it even more difficult to collect data and figure out what ancedotal evidence is worth considering and what anecdotal evidence is not. Especially when it comes to secretagogues.

I have never run GH before but I understand that you need to experiment with different doses and figure out what works best for yourself. But I still need to know what the average range is for what purpose which is why I wanted to ask.

Like it wouldn't make sense to start experimenting somatropin 0.1 IU/day (waste of time and money) and it wouldn't make sense to start with 50 IU/day (dangerous) either, I want to know what a good starting point for titration is given my goals.

 

[Ghoul]

15iu+ or you're wasting your time...

It's funny that people here think they can be successful with 2-6 IU hgh.
These people can also inject water and think muscles grow. Below 15 IU hgh, somatropin makes absolutely no sense.

Real effects on muscle building only become apparent with very high doses of HGH.

So please stop believing that 2-6 IU of HGH has any effect other than on your head.

Waste of money and time

 

[Ghoul]

Okay thank you. Since there is so much individual variance between how people respond that makes it even more difficult to collect data and figure out what ancedotal evidence is worth considering and what anecdotal evidence is not. Especially when it comes to secretagogues.

I have never run GH before but I understand that you need to experiment with different doses and figure out what works best for yourself. But I still need to know what the average range is for what purpose which is why I wanted to ask.

Like it wouldn't make sense to start experimenting somatropin 0.1 IU/day (waste of time and money) and it wouldn't make sense to start with 50 IU/day (dangerous) either, I want to know what a good starting point for titration is given my goals.

What are your goals? To stay on HGH essentially, forever? Because when you come off, the benefits evaporate.

If that's the case, maybe ask that question.

"How should I use HGH forever, as an anti-aging compound"

Wouldn't mind hearing views on how that's done safely myself. I'm not opposed to GH, and see its advantages, but Tesa seems so much easier if maximizing safety, staying on for the long term, and simplicity are factors.

 

[Ateam2023]

Okay thank you. Since there is so much individual variance between how people respond that makes it even more difficult to collect data and figure out what ancedotal evidence is worth considering and what anecdotal evidence is not. Especially when it comes to secretagogues.

I have never run GH before but I understand that you need to experiment with different doses and figure out what works best for yourself. But I still need to know what the average range is for what purpose which is why I wanted to ask.

Like it wouldn't make sense to start experimenting somatropin 0.1 IU/day (waste of time and money) and it wouldn't make sense to start with 50 IU/day (dangerous) either, I want to know what a good starting point for titration is given my goals.

start at 1 iu daily for a week, then 2 ius week then 3 ius etc, all the way up till you get CTS then back off a little and take an assessment ,,,, Drink plenty of WATER,,,, buy a glucose meter,,,,, goodluck

 

[mikeh1998]

What are your goals? To stay on HGH essentially, forever? Because when you come off, the benefits evaporate.

If that's the case, maybe ask that question.

"How should I use HGH forever, as an anti-aging compound"

Wouldn't mind hearing views on how that's done safely myself. I'm not opposed to GH, and see its advantages, but Tesa seems so much easier if maximizing safety, staying on for the long term, and simplicity are factors.

I can give more context.

Current blast

* 26M 183 lb running 1.25g of Test C until May with goal weight 210 lb.
* Looking for a compound to compliment my blast - better sleep, more appetite, more muscle gain and less fat gain
* I am willing to inject multiple times per day if necessary while blasting
* I am willing to use a compound that is "expensive" since this is short term
* I am willing to take risk and suffer transient side effects (I can deal with bloating or feeling a little more tired in the evening) but not permanent side effects (gynecomastia or nose/mouth growth, some COCK growth would be welcome though)

Long term

* Will drop down to 100-150 mg Test C for life, also willing to use hGH or a related peptide for life. I have already signed up for using Tirz for life, that's the only other peptide I use.
* I want better sleep and I highly value looking young and healthy (a collagen booster would help a lot)
* I am not really willing to do a complicated injection schedule in the long term. If I could inject once a day or even once a week that would be ideal.
* I want to have minimal side effects while not blasting, I don't want to have to deal with managing peptide induced fatigue

Current thoughts

So far as I know Pfizer Ngenla allows for weekly injections but the cost per IU is more than 10x the cost of Chinese hGH making it completely out of the questions for blasting. However there's a tiny chance that I might determine the cost difference is worth the convenience of needing less injections while cruising so I haven't totally ruled it out.

Tesa sounds promising based on it not affecting insulin like you mentioned in your previous post and also increasing GH throughout the day, not requiring me to stress about injecting during my day to day life.

I saw you mention in another thread that it's the only/one of the only drugs that has been shown to be safe and FDA approved for treating HIV patients so that is relieving.

If think the next thing for me is to calculate how affordable it is to add in Tesa long term and how easy it is to get a stash of some to last a few years. When I briefly skimmed a pricelist earlier today I remember being worried about the cost of using it at 1 mg/day. I'll re-evaluate that.

Wildcard here is maybe hGH is just so fucking good I decide to just keep using it and end up not minding just using straight hGH with 1-2x injections per day instead of a secretagogue altogether.