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Peptide vials of SLU-PP-332

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Frontdouble

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Has anyone tried the 5mg or 10mg of SLU-PP-333 that comes in the peptide vials sold by these Chinese vendors? Is it as simple as reconstituting it with bac? Can’t seem to find any information on these injectable SLU-PP-332 to all?
 
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I've heard that most vendors put an additive in the powder to make it dissolve in BAC water. I would like to know how well it works though, as there's a bunch of vendors that only stock injectable but not oral SLU. Also, since it's better to take high doses for proper results you would have to inject an entire vial to get 5mg a day...
 
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lucario said:
I've heard that most vendors put an additive in the powder to make it dissolve in BAC water. I would like to know how well it works though, as there's a bunch of vendors that only stock injectable but not oral SLU. Also, since it's better to take high doses for proper results you would have to inject an entire vial to get 5mg a day...
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That’s the confusing part hey, you would think that the peptide version is so sort different where you require less dosage compared to the oral. Essentially like injectable L carnitine versus oral.

Sucks there’s hardly any information out there about injectable slu or people trying it. Would assume 250mcg injected will be stronger than 250mcg oral as it goes straight into the blood stream.
 
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Frontdouble said:
That’s the confusing part hey, you would think that the peptide version is so sort different where you require less dosage compared to the oral. Essentially like injectable L carnitine versus oral.

Sucks there’s hardly any information out there about injectable slu or people trying it. Would assume 250mcg injected will be stronger than 250mcg oral as it goes straight into the blood stream.
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What I heard on some bodybuilding podcasts like Unwracked is that oral SLU is like 60-80% bioavailable which would mean that 5mg injectable would be about as good as 8mg oral. Not worth it to me considering you would have to pin a whole vial per day. Plus it would cost like 10$ per day lmao, get the fuck outta here.
 
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Theoretically speaking, there is more data on the injection because that's how it was done in the studies in mice.

There were a couple of them, it was 30mg/kg in one study and 50mg/kg in the other. But mice dosing isn't the same as human dosing.

The formula according to the FDA to convert between species is:

HED (mg/kg) = Animal Dose (mg/kg) * (Animal K_m / Human K_m)

So long story short, for SLU the mice to human conversion would be:

Average Mouse 80 kg Human (176 lbs in Freedom Units)
50kg/mg295.2 mg
30kg/mg176.8 mg

The only problem left here is that often these studies (especially the early ones like these) are done in mice to see what the maximum dose is without them dying. So this is all far from optimal and from what I've read in reports so far, way too high. Also, it was only done for like 10 days I believe.

slupp.webp
 
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gainslol said:
Theoretically speaking, there is more data on the injection because that's how it was done in the studies in mice.

There were a couple of them, it was 30mg/kg in one study and 50mg/kg in the other. But mice dosing isn't the same as human dosing.

The formula according to the FDA to convert between species is:

HED (mg/kg) = Animal Dose (mg/kg) * (Animal K_m / Human K_m)

So long story short, for SLU the mice to human conversion would be:

Average Mouse 80 kg Human (176 lbs in Freedom Units)
50kg/mg295.2 mg
30kg/mg176.8 mg

The only problem left here is that often these studies (especially the early ones like these) are done in mice to see what the maximum dose is without them dying. So this is all far from optimal and from what I've read in reports so far, way too high. Also, it was only done for like 10 days I believe.

View attachment 371785
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Appreciate the share @gainslol. Does the study show if they used bac water? Is it safe to say we can use bac water if vendors are selling it in peptide vials?
 
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just take it orally. there is slu-pp-915 which was made to have higher oral availability compared to 332 but its new and raws are super expensive. iirc somewhere around $11k for 100G, more than 10x the price of 332 raws. 332 oral works fine for me, i'd rather take more oral than less injectable and having to use dmso
 
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Frontdouble said:
Appreciate the share @gainslol. Does the study show if they used bac water? Is it safe to say we can use bac water if vendors are selling it in peptide vials?
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My bad, should have linked the study (I agree with @BigTomJ though, I wouldn't inject this) :

Three-month-old C57Bl6/J male mice (n = 3) were injected (i.p.) at ZT 1 with 30 mg/kg of SLU-PP-332 (5% Tween–5% DMSO–90% PBS).

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity - PMC

Repetitive physical exercise induces physiological adaptations in skeletal muscle that improves exercise performance and is effective for the prevention and treatment of several diseases. Genetic evidence indicates that the orphan nuclear receptors ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
 
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gainslol said:
My bad, should have linked the study (I agree with @BigTomJ though, I wouldn't inject this) :

Three-month-old C57Bl6/J male mice (n = 3) were injected (i.p.) at ZT 1 with 30 mg/kg of SLU-PP-332 (5% Tween–5% DMSO–90% PBS).

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity - PMC

Repetitive physical exercise induces physiological adaptations in skeletal muscle that improves exercise performance and is effective for the prevention and treatment of several diseases. Genetic evidence indicates that the orphan nuclear receptors ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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I have tried this exact formula, and it doesn't produce a stable solution.
Like 2.5mg tops. But even then it was very unstable partially falling out of solution.

For that study they were likely doing the injections as a partial suspension.
 
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I am reading the paper on the new slupp935, and they keep hammering the point that slupp32 has little no oral bioavailability. So I don't quite understand how people are getting something other than placebo in many cases. At least that partly explains the wild dosage variation from 200mcg to 20mg.

See https://www.sciencedirect.com/science/article/pii/S0022356525403000
 

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I just bought a kit and had absolutely no idea about it needing DMSO, which I refuse to even think about using.

I also heard Janoshick on a podcast saying if it's Lyophilized then it's ruined, it can't be SLU-PP-332. Any idea how can this be sold as Lyophilized when you can't use BAC?
Any suggestions?


​

 
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EnhancedPhysio said:
I just bought a kit and had absolutely no idea about it needing DMSO, which I refuse to even think about using.

I also heard Janoshick on a podcast saying if it's Lyophilized then it's ruined, it can't be SLU-PP-332. Any idea how can this be sold as Lyophilized when you can't use BAC?
Any suggestions?


​

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people are dumb and buying it without understanding or worse, they are using DMSO to recon
 
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For all you guys in the U.S. this is a very viable option! Plenty of feedback on pro muscle about this stuff.

I believe the 915 version is available too.

Unfortunately i'm in uk & Mike won't send over here.
 
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GreatOak said:
For all you guys in the U.S. this is a very viable option! Plenty of feedback on pro muscle about this stuff.

I believe the 915 version is available too.

Unfortunately i'm in uk & Mike won't send over here.
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I reached out and he confirmed no DMSO at all. They have a 50mg version on the website that looks like it's out of stock.
 
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Proud Pangolin said:
do you want to inject 200mg-400mg every day? meaning 4-8 viales per day? Is that your plan?

It absolutely buffels me that people never care about reading the studys and calculating the equivalent human dia
Click to expand...

Oh I have zero interest in using SLU, it's just that the stuff I'm looking at can only be dissolved in DMSO so here I am looking at similar compounds lol
 
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