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Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
If the hypothesis is correct that fructose has a role in the epidemic of cardiovascular disease, then a number of predictions should arise from future studies. First, fructose intake will be a risk factor for hypertension, insulin resistance, hypertriacylglycerolemia, obesity, type 2 diabetes, preeclampsia, chronic kidney disease, stroke, cardiovascular disease, and mortality. Second, reducing uric acid in patients with uric acid concentrations >6.0 mg/dL will improve endothelial dysfunction, decrease systemic vascular resistance, lower blood pressure, lower triacylglycerol concentrations, improve body weight, lower the risk of the progression of renal disease, and reduce cardiovascular disease risk. Third, low-fructose diets coupled with mild purine restriction will improve weight and reduce cardiovascular disease risk. Fourth, fructokinase will be identified as a key enzyme mediating the cardiorenal disease syndrome; genetic polymorphisms will be associated with cardiovascular disease risk, and blocking the enzyme will provide a novel way to prevent cardiorenal disease. Clearly, much more work needs to be done to prove or disprove this hypothesis.
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
If the hypothesis is correct that fructose has a role in the epidemic of cardiovascular disease, then a number of predictions should arise from future studies. First, fructose intake will be a risk factor for hypertension, insulin resistance, hypertriacylglycerolemia, obesity, type 2 diabetes, preeclampsia, chronic kidney disease, stroke, cardiovascular disease, and mortality. Second, reducing uric acid in patients with uric acid concentrations >6.0 mg/dL will improve endothelial dysfunction, decrease systemic vascular resistance, lower blood pressure, lower triacylglycerol concentrations, improve body weight, lower the risk of the progression of renal disease, and reduce cardiovascular disease risk. Third, low-fructose diets coupled with mild purine restriction will improve weight and reduce cardiovascular disease risk. Fourth, fructokinase will be identified as a key enzyme mediating the cardiorenal disease syndrome; genetic polymorphisms will be associated with cardiovascular disease risk, and blocking the enzyme will provide a novel way to prevent cardiorenal disease. Clearly, much more work needs to be done to prove or disprove this hypothesis.
