Pramipexole raw in PEG 400 Shelf Life?

[Plate Smacker]

Just got some PEG 400 in with some other supplies. Was going to use it for Nolvadex, Aromasin, Cialis and some Pramipexole.

I was going to mix up Prami 30ml @ 1mg/ml in the PEG 400.
Would this be stable?
How long?

Side Note: Not going to mix it right now because I am cruising @ 160-180mg/ wk for 10 weeks then bloodwork.
However, next blast I am running deca and just want to have it on hand.
I have ran NPP @70mg ED (490/wk) with 900mg/wk Test E. with only 6mg aromasin. No problems, bloodwork fine.

 

[joevette]

The molecular weight of pramipexole is 211.324 g/mol. So peg 200 would be ideal.

 

[Plate Smacker]

Thanks, but would PEG 400 work? As we all know, prami isn't something you wanna screw up when making.
Also:
Any keywords for researching the link between molecular weight of raw and preferred vehicle?

 

[joevette]

I think it would since you're only making it at a 1 mg/ml concentration. Personally, I'd spring for the peg 200 just to be safe.

 

[Plate Smacker]

Edited and added this during your response.
Also:
Any keywords for researching the link between molecular weight of raw and preferred vehicle?

 

[joevette]

Just match the molecular weight to the type of peg. Like Prami has a molecular weight of 211.324 g/mol so you'd use peg 200 since that's very close.
Currently I am making a liquid oral with lgd-4033 that I put into an eye dropper (1 drop=15mg) for covert use around the wife. lgd-4033 has a molecular weight of 338.253 g/mol, so I'm using peg 300.

 

[Plate Smacker]

Thanks alot for that info.

 

[Plate Smacker]

To be clear, I can ingest this right lol?
I mean, I am reading studies, and uses, and that it's fine.
I just tasted a drop of PEG 400 and it actually creates a very warm feeling on my tongue. Something like a warming lubricant that is available as an intimacy product/lubricant. (If you have used one).
I am using straight Polyethylene Glycol 400.
Is this normal, the warming sensation.???

Serving size will be 1ml with an oral syringe. Photos below.

So, I just whipped up 600mg Tadalafil into 30ml @20mg/ml. Used PEG 400.
Tadalafil Solubility:
"PEG-400 (polyethylene glycol 400) 23.76 mg/ml
PG (propylene glycol) 3.66 mg/ml
Ethanol 3.54 mg/ml
Water 0.02 mg/ml
https://www.jstage.jst.go.jp/article/jos/63/6/63_ess13236/_pdf

 

[joevette]

Yes, the warming sensation is normal. It is safe to ingest orally.

 

[master.on]

View attachment 88849 Just got some PEG 400 in with some other supplies. Was going to use it for Nolvadex, Aromasin, Cialis and some Pramipexole.

I was going to mix up Prami 30ml @ 1mg/ml in the PEG 400.
Would this be stable?
How long?

Side Note: Not going to mix it right now because I am cruising @ 160-180mg/ wk for 10 weeks then bloodwork.
However, next blast I am running deca and just want to have it on hand.
I have ran NPP @70mg ED (490/wk) with 900mg/wk Test E. with only 6mg aromasin. No problems, bloodwork fine.

Does Prami decompose in water?
Because it seems to be soluble in water

Pramipexole dihydrochloride A1237

Pramipexole dihydrochloride monohydrate | CAS 191217-81-9

So why bother with PEG and its nasty taste?

Be aware that the 20 mg/ml solubility figure is usually only attainable by using very pure, true lab grade Prami and Water.
So settle for 10 mg/ml or less.

 

[Plate Smacker]

I am reading it's pretty stable.
I am wondering if it would degrade in PEG 400 though.
May end up using distilled water @ 1mg/ml.

Pramipexole Chemistry

"Pramipexole dihydrochloride monohydrate drug substance is a very stable compound. In the solid state and in solutions stored at ambient temperature, pramipexole dihydrochloride monohydrate does not degrade."