Proviron!

[einstein1905]

i would like to wee some research that actually shows that proviron is an aromatase inhibitor. To the best of my knowledge, none exists. Clearly proviron is NOT dht nor does it act like dht, it is just similar in chemical makeup.

jb

Proviron will have essentially the same actions as DHT, considering the similar structure
J Clin Endocrinol Metab. 1984 Mar;58(3):467-72. Related Articles, Links


The intracellular control of aromatase activity by 5 alpha-reduced androgens in human breast carcinoma cells in culture.

Perel E, Stolee KH, Kharlip L, Blackstein ME, Killinger DW.

Four cell lines, each derived from a primary tumor from a patient with breast carcinoma, were grown to confluence in alpha-Minimum Essential Medium with 15% fetal calf serum and incubated for 24 h with [3H]androstenedione. The two lines (SA and PP) with the lowest formation of estrone and estradiol (less than 0.1% conversion) were the most active in the formation of the 5 alpha-reduced androgen metabolites androsterone (AND), 5 alpha-androstanedione (5 alpha-A-dione), and dihydrotestosterone (DHT). The two lines with the highest aromatase activity (DM and MD) had the lowest formation of 5 alpha-reduced metabolites. To determine if the 5 alpha-reduced androgen metabolites formed within the breast carcinoma cells could influence aromatase activity, the MD line was further studied. After 24-h preincubation with AND, DHT, or 5 alpha-A-dione at concentrations of 10(-6), 10(-7), and 10(-8) M, [3H]androstenedione was added to the culture medium, and aliquots were removed at 0, 4, 8, and 24 h. An 8-h incubation period was found to be optimum for inhibition studies. In comparison to control levels of estrone (2.5%) and estradiol (0.35%) formation, inhibition of aromatization was evident with all three compounds at 10(-8) M, with 5 alpha-A-dione producing the greatest inhibition (50%). At 10(-7) M, inhibition ranged from 45% (AND) to 70% (5 alpha-A-dione), and at 10(-6) M, inhibition was greater than 90% for each compound. 5 alpha-A-dione produced slightly greater inhibition than AND or DHT at each concentration tested. Since each of these compounds was capable of inhibiting aromatization, the cumulative effect of these 5 alpha-reduced metabolites could be an important factor in the intracellular regulation of aromatase activity.

 

[aquafina]

-But will it make my hair fall out?!?!
Even more so if used with Winny?

 

[einstein1905]

-But will it make my hair fall out?!?!
Even more so if used with Winny?

Winny plus proviron is begging for hairloss, and no finasteride will stop that. If you're susceptible to MPB, the 2 won't likely be kind to your hairline.

 

[Ronin_]

Proviron adds hardness when youre cut, especially if you aren't using much test to cut up. It also helps out libido if doing anabolics only, say primo and var to cut up