PT - 141

I’ve been taking mt2 at 600-1000mcg a night for like 10 days now, with the exception of the last 3 nights.

Moles and freckles have gotten a lot darker. My genitals are still the same color. Last time I took mt2 my cock n balls went black, but I was on it for months last time.
Nocturnal erections have been present every time I’ve woken up in the night. And erection quality has been much better throughout the day.

Contrary to the recommendation that MCR agonists are dosed an hour before sexual activity, I find the pro-sexual effects peak many hours after dosing. I’d guess around 4 hours after a dose.

I’ve not taken mt2 for the last 3 days, but my nocturnal and waking erections are still much better than baseline. So I dunno what’s going on there. Maybe improved vascular function from the surplus of nocturnal erections. Maybe the physiological effects of mt2 linger for days.

Libido is better, but that may simply be from the erection quality.

I’ve noticed no side effects from the mt2 other than a possible reduction in appetite. I’ve always been concerned with my blood pressure on MCR agonists, as that is meant to be a big risk, but my BP has been better while on it than at any other time in the last 5 years. So it certainly isn’t having a deleterious effect on my BP.

My appetite has gone up since I’ve taken a 3 day break from mt2. But that may be due to other factors. I’m going back on mt2 tonight, so I should find out tomorrow if my appetite is suppressed from the mt2.

If and when I get dark and handsome (the second one might take a while lol), I’m going to drop the mt2 and switch to pt141. I’ll then switch back to mt2 once I can handle being darker without also switching ethnicities.

I’m very happy with mt2 this time around, and presumably also pt141 by extrapolation.

I am concerned that pt141 may have weaker pro-sexual effects, or that its half life is shorter than mt2. This is because I don’t remember pt141 being as good per mcg as I feel this time around on mt2. But this would only be a problem if I get too dark on the mt2 and need to switch to pt141.
 
I’ve been taking mt2 at 600-1000mcg a night for like 10 days now, with the exception of the last 3 nights.

Moles and freckles have gotten a lot darker. My genitals are still the same color. Last time I took mt2 my cock n balls went black, but I was on it for months last time.
Nocturnal erections have been present every time I’ve woken up in the night. And erection quality has been much better throughout the day.

Contrary to the recommendation that MCR agonists are dosed an hour before sexual activity, I find the pro-sexual effects peak many hours after dosing. I’d guess around 4 hours after a dose.

I’ve not taken mt2 for the last 3 days, but my nocturnal and waking erections are still much better than baseline. So I dunno what’s going on there. Maybe improved vascular function from the surplus of nocturnal erections. Maybe the physiological effects of mt2 linger for days.

Libido is better, but that may simply be from the erection quality.

I’ve noticed no side effects from the mt2 other than a possible reduction in appetite. I’ve always been concerned with my blood pressure on MCR agonists, as that is meant to be a big risk, but my BP has been better while on it than at any other time in the last 5 years. So it certainly isn’t having a deleterious effect on my BP.

My appetite has gone up since I’ve taken a 3 day break from mt2. But that may be due to other factors. I’m going back on mt2 tonight, so I should find out tomorrow if my appetite is suppressed from the mt2.

If and when I get dark and handsome (the second one might take a while lol), I’m going to drop the mt2 and switch to pt141. I’ll then switch back to mt2 once I can handle being darker without also switching ethnicities.

I’m very happy with mt2 this time around, and presumably also pt141 by extrapolation.

I am concerned that pt141 may have weaker pro-sexual effects, or that its half life is shorter than mt2. This is because I don’t remember pt141 being as good per mcg as I feel this time around on mt2. But this would only be a problem if I get too dark on the mt2 and need to switch to pt141.

You need larger doses of PT-141 than MT-2 for effectiveness. 2.5-3.5mg.
 
I give up on this peptide... first attempt 1mg nothing, just boners. Second attempt 1.5mg nothing, just boners. Third and final attempt today 2.5mg nothing, just boners. No libido increase whatsoever... I envy some of you guys.

Next I will try Oxytocin.
 
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I give up on this peptide... first attempt 1mg nothing, just boners. Second attempt 1.5mg nothing, just boners. Third and final attempt today 2.5mg nothing, just boners. No libido increase whatsoever... I envy some of you guys.

Next I will try Oxytocin.
At 1mg it felt just like cialis or viagra to me. Same crippling headaches as well.
 
I give up on this peptide... first attempt 1mg nothing, just boners. Second attempt 1.5mg nothing, just boners. Third and final attempt today 2.5mg nothing, just boners. No libido increase whatsoever... I envy some of you guys.

Next I will try Oxytocin.
I mean thats the point of PT141, boners right? Better erections? So it is working, you might just respond differently to it.
 
I mean thats the point of PT141, boners right? Better erections? So it is working, you might just respond differently to it.
I can get boners with Cialis, without the flushing, headache, nausea, and having to time the injection perfectly.

PT141 is supposed to enhance the sex lust and make you horny, enjoy sex more, have better orgasms, etc. Someone on the last page even experienced euphoria lol

Just didn't work for me.
 
Just found this out today. Agonism of the melanocortin system can stimulate thyroid function. This may explain some of the metabolic changes seen with such agonism.

I’ve found my thyroid to be sub clinically overactive, and I suspect HCG as the cause. I’ve not yet tested my thyroid whilst on an MCRa.

I’m gonna be doing a thyroid test in the next few weeks, and I’ll take 1mg of mt2 12 hours prior to see if it has much of an impact.

Will report back if it’s interesting
 
Just found this out today. Agonism of the melanocortin system can stimulate thyroid function. This may explain some of the metabolic changes seen with such agonism.

I’ve found my thyroid to be sub clinically overactive, and I suspect HCG as the cause. I’ve not yet tested my thyroid whilst on an MCRa.

I’m gonna be doing a thyroid test in the next few weeks, and I’ll take 1mg of mt2 12 hours prior to see if it has much of an impact.

Will report back if it’s interesting
TSH was the highest it’s ever been, but well within range. FT4 on the higher end, but not unusual for me.

So for my anecdote: MCRas at a moderate dose 12 hours after dosing don’t have much, if any, impact on thyroid function.
 
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I give up on this peptide... first attempt 1mg nothing, just boners. Second attempt 1.5mg nothing, just boners. Third and final attempt today 2.5mg nothing, just boners. No libido increase whatsoever... I envy some of you guys.

Next I will try Oxytocin.
I know I am late to this thread but I am in the same boat, the wife and I tried it and it made my face red but other than that nothing, I dont have a problem with doing anything but we heard it made it more pleasurable and wanted to try it. Did not work on either of us.
 
I know I am late to this thread but I am in the same boat, the wife and I tried it and it made my face red but other than that nothing, I dont have a problem with doing anything but we heard it made it more pleasurable and wanted to try it. Did not work on either of us.
What dose? And how long after dosing did you assess the feels?
 
I know I am late to this thread but I am in the same boat, the wife and I tried it and it made my face red but other than that nothing, I dont have a problem with doing anything but we heard it made it more pleasurable and wanted to try it. Did not work on either of us.
What dose did you try?
 
What dose did you try?
I ended up doing 2mg and she did 2.5mg but I didnt want to go any further as the flushing got pretty intense. The feeling of flushing was almost instant. The wood was there but it was around 4 hours later when it would just spring up out of nowhere lol and usually at around 2am when she was sleeping.
 
Interested in hearing individual results. What did you experience? Sides effects? Dosage? Important info before diving in… ( no pun intended)
Bought this from a registered compounding pharmacy when living in Australia - my partner and I took it according to recommended dosage. It definitely works but the nausea was so intense and off putting that it wasn't a great experience. Like being horny and having morning sickness at the same time.

The sex was more about 'scratching the itch' than a great sexual experience, wasn't worth it imo, but ymmv.

We haven't bought it since though.
 
Well, I tried 3mg dose, per Ghoul's suggestion, along with 20mg tadalafil for the first time last night. Side effects were as advertised; nausea and flushing. I can honestly say that I have never experienced anything like that. The wife snuck out in the middle of the night to sleep in a spare room and get away from me and my perma-boner. Understand that I am in my 50s and this is not a normal thing for me. I will be keeping a supply of PT-141 around. Worst sleep though. My whoop monitor says I got zero sleep. Anyone else have bad sleep on this?
 
Well, I tried 3mg dose, per Ghoul's suggestion, along with 20mg tadalafil for the first time last night. Side effects were as advertised; nausea and flushing. I can honestly say that I have never experienced anything like that. The wife snuck out in the middle of the night to sleep in a spare room and get away from me and my perma-boner. Understand that I am in my 50s and this is not a normal thing for me. I will be keeping a supply of PT-141 around. Worst sleep though. My whoop monitor says I got zero sleep. Anyone else have bad sleep on this?
how accurate is your whoop? Do you find it to be accurate as advertised?
 
how accurate is your whoop? Do you find it to be accurate as advertised?
IMO, as a fitness tracker, it's the worst of the 3 big ones (fitbit, apple, whoop). I have used all 3. For general heath analytics, this is where it shines. I bought it because I had borderline sleep apnea and was trying to avoid using a CPAP. The data it provides is better than what the sleep studies they prescribe. If you want to get into the nitty gritty of all your biomarkers for optimizing, whoop is what you want. If you want to track fitness activities, the other trackers are better. Whoop also uses a subscription model, so it costs more in the long run. After this second year with it, I will probably retire it.
 
Bought this from a registered compounding pharmacy when living in Australia - my partner and I took it according to recommended dosage. It definitely works but the nausea was so intense and off putting that it wasn't a great experience. Like being horny and having morning sickness at the same time.

The sex was more about 'scratching the itch' than a great sexual experience, wasn't worth it imo, but ymmv.

We haven't bought it since though.
First time I took pt141 was shit. Felt like I was dying from how sick I felt. Sexual functioning was no better 2 hours after dosing, and due to the nausea it was actually anti-sexual.

I find it took maybe 20 doses before the nausea almost entirely wore off. I also find the pro-sexual effects peak around 5 hours after dosing.
 
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