Nothing without bloods. Primo doesn’t lower e2 much for some people , myself included. I can run 250 test and 600+ primo and still have 90 e2 so I need to run Aromasin on top. Less than I would if I were just on test but i don’t consider primo an AI substitute *in my case*
/:/ edit. DO NOT rely on side effects to gauge if you’re too low or too high with e2. Sometimes they can be similar. I thought I was crashing my e2 but went for blood work and turned out I was over twice the upper reference range for e2.